Human Gene SSR3 (ENST00000265044.7_6) from GENCODE V47lift37

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Description: signal sequence receptor subunit 3, transcript variant 2 (from RefSeq NM_007107.5)
Gencode Transcript: ENST00000265044.7_6
Gencode Gene: ENSG00000114850.7_7
Transcript (Including UTRs)
Position: hg19 chr3:156,257,342-156,272,906 Size: 15,565 Total Exon Count: 5 Strand: -
Coding Region
Position: hg19 chr3:156,260,992-156,272,878 Size: 11,887 Coding Exon Count: 5

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr3:156,257,342-156,272,906)			mRNA (may differ from genome)		Protein (185 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	Reactome	UniProtKB
BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: SSRG_HUMAN DESCRIPTION: RecName: Full=Translocon-associated protein subunit gamma; Short=TRAP-gamma; AltName: Full=Signal sequence receptor subunit gamma; Short=SSR-gamma; FUNCTION: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. SUBUNIT: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma. INTERACTION: Q9BUV8:C20orf24; NbExp=1; IntAct=EBI-1043938, EBI-1050079; P48634:PRRC2A; NbExp=1; IntAct=EBI-1043938, EBI-347545; SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the TRAP-gamma family.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
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To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D006861 Hydrogen Peroxide D010634 Phenobarbital C014024 2,4,5,2',4',5'-hexachlorobiphenyl C016403 2,4-dinitrotoluene C016392 3,3'-diindolylmethane D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide C547126 AZM551248 D000082 Acetaminophen D001241 Aspirin D019256 Cadmium Chloride D020111 Chlorodiphenyl (54% Chlorine) D002737 Chloroprene D002762 Cholecalciferol D002994 Clofibrate D003300 Copper D019327 Copper Sulfate D016572 Cyclosporine D003993 Dibutyl Phthalate D004041 Dietary Fats D004958 Estradiol D005839 Gentamicins D008627 Mercuric Chloride D008748 Methylcholanthrene D008767 Methylmercury Compounds D018817 N-Methyl-3,4-methylenedioxyamphetamine D010894 Piroxicam D011078 Polychlorinated Biphenyls D011285 Pregnenolone Carbonitrile D011794 Quercetin D013749 Tetrachlorodibenzodioxin D013806 Theophylline C006780 bisphenol A C018021 cobaltous chloride C076994 perfluorooctane sulfonic acid C023036 perfluorooctanoic acid C045950 propiconazole C009277 sodium arsenate D020122 tert-Butylhydroperoxide C032910 triadimefon C015559 trimellitic anhydride

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 65.58 RPKM in Cells - Cultured fibroblasts Total median expression: 1204.12 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-2.80	28	-0.100	Picture	PostScript	Text
3' UTR	-1132.10	3650	-0.310	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR009779 - TRAP-gamma

Pfam Domains:
PF07074 - Translocon-associated protein, gamma subunit (TRAP-gamma)

ModBase Predicted Comparative 3D Structure on Q9UNL2


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	Genome Browser	No ortholog
Gene Details	Gene Details		Gene Details	Gene Details
Gene Sorter	Gene Sorter		Gene Sorter	Gene Sorter
	RGD	Ensembl		WormBase
				Protein Sequence
				Alignment

Gene Ontology (GO) Annotations with Structured Vocabulary


	Biological Process: GO:0006614 SRP-dependent cotranslational protein targeting to membrane Cellular Component: GO:0005622 intracellular GO:0005783 endoplasmic reticulum GO:0005789 endoplasmic reticulum membrane GO:0016020 membrane GO:0016021 integral component of membrane

Descriptions from all associated GenBank mRNAs


	KJ892205 - Synthetic construct Homo sapiens clone ccsbBroadEn_01599 SSR3 gene, encodes complete protein. LF206136 - JP 2014500723-A/13639: Polycomb-Associated Non-Coding RNAs. MA441713 - JP 2018138019-A/13639: Polycomb-Associated Non-Coding RNAs. LF351790 - JP 2014500723-A/159293: Polycomb-Associated Non-Coding RNAs. AF110647 - Homo sapiens translocon-associated protein gamma subunit mRNA, complete cds. JD302044 - Sequence 283068 from Patent EP1572962. JD227978 - Sequence 209002 from Patent EP1572962. LF351791 - JP 2014500723-A/159294: Polycomb-Associated Non-Coding RNAs. JD467793 - Sequence 448817 from Patent EP1572962. LF351792 - JP 2014500723-A/159295: Polycomb-Associated Non-Coding RNAs. LF351793 - JP 2014500723-A/159296: Polycomb-Associated Non-Coding RNAs. JD146947 - Sequence 127971 from Patent EP1572962. JD553734 - Sequence 534758 from Patent EP1572962. BC017203 - Homo sapiens signal sequence receptor, gamma (translocon-associated protein gamma), mRNA (cDNA clone MGC:3501 IMAGE:3618589), complete cds. JD241190 - Sequence 222214 from Patent EP1572962. JD240600 - Sequence 221624 from Patent EP1572962. JD194530 - Sequence 175554 from Patent EP1572962. JD440381 - Sequence 421405 from Patent EP1572962. JD339470 - Sequence 320494 from Patent EP1572962. JD062037 - Sequence 43061 from Patent EP1572962. JD472234 - Sequence 453258 from Patent EP1572962. JD154959 - Sequence 135983 from Patent EP1572962. JD294044 - Sequence 275068 from Patent EP1572962. JD198956 - Sequence 179980 from Patent EP1572962. LF351794 - JP 2014500723-A/159297: Polycomb-Associated Non-Coding RNAs. JD523984 - Sequence 505008 from Patent EP1572962. JD085315 - Sequence 66339 from Patent EP1572962. LF351795 - JP 2014500723-A/159298: Polycomb-Associated Non-Coding RNAs. JD508112 - Sequence 489136 from Patent EP1572962. LF351796 - JP 2014500723-A/159299: Polycomb-Associated Non-Coding RNAs. JD214581 - Sequence 195605 from Patent EP1572962. JD338415 - Sequence 319439 from Patent EP1572962. JD252854 - Sequence 233878 from Patent EP1572962. JD563646 - Sequence 544670 from Patent EP1572962. JD081092 - Sequence 62116 from Patent EP1572962. LF351797 - JP 2014500723-A/159300: Polycomb-Associated Non-Coding RNAs. JD521663 - Sequence 502687 from Patent EP1572962. JD560599 - Sequence 541623 from Patent EP1572962. LF351798 - JP 2014500723-A/159301: Polycomb-Associated Non-Coding RNAs. JD037732 - Sequence 18756 from Patent EP1572962. LF351799 - JP 2014500723-A/159302: Polycomb-Associated Non-Coding RNAs. JD554631 - Sequence 535655 from Patent EP1572962. JD233570 - Sequence 214594 from Patent EP1572962. JD041800 - Sequence 22824 from Patent EP1572962. AK304364 - Homo sapiens cDNA FLJ52061 complete cds, highly similar to Translocon-associated protein subunit gamma. LF351800 - JP 2014500723-A/159303: Polycomb-Associated Non-Coding RNAs. AF087907 - Homo sapiens SSR gamma mRNA, complete cds. JD046364 - Sequence 27388 from Patent EP1572962. JD023701 - Sequence 4725 from Patent EP1572962. JD391899 - Sequence 372923 from Patent EP1572962. BT006669 - Homo sapiens signal sequence receptor, gamma (translocon-associated protein gamma) mRNA, complete cds. DQ892572 - Synthetic construct clone IMAGE:100005202; FLH187663.01X; RZPDo839B10150D signal sequence receptor, gamma (translocon-associated protein gamma) (SSR3) gene, encodes complete protein. AK312935 - Homo sapiens cDNA, FLJ93386, Homo sapiens signal sequence receptor, gamma (translocon-associatedprotein gamma) (SSR3), mRNA. DQ895788 - Synthetic construct Homo sapiens clone IMAGE:100010248; FLH187659.01L; RZPDo839B10149D signal sequence receptor, gamma (translocon-associated protein gamma) (SSR3) gene, encodes complete protein. LF351802 - JP 2014500723-A/159305: Polycomb-Associated Non-Coding RNAs. JD025968 - Sequence 6992 from Patent EP1572962. JD034016 - Sequence 15040 from Patent EP1572962. LF351808 - JP 2014500723-A/159311: Polycomb-Associated Non-Coding RNAs. DL492516 - Novel nucleic acids. DL490985 - Novel nucleic acids. JD526154 - Sequence 507178 from Patent EP1572962. MA587367 - JP 2018138019-A/159293: Polycomb-Associated Non-Coding RNAs. MA587368 - JP 2018138019-A/159294: Polycomb-Associated Non-Coding RNAs. MA587369 - JP 2018138019-A/159295: Polycomb-Associated Non-Coding RNAs. MA587370 - JP 2018138019-A/159296: Polycomb-Associated Non-Coding RNAs. MA587371 - JP 2018138019-A/159297: Polycomb-Associated Non-Coding RNAs. MA587372 - JP 2018138019-A/159298: Polycomb-Associated Non-Coding RNAs. MA587373 - JP 2018138019-A/159299: Polycomb-Associated Non-Coding RNAs. MA587374 - JP 2018138019-A/159300: Polycomb-Associated Non-Coding RNAs. MA587375 - JP 2018138019-A/159301: Polycomb-Associated Non-Coding RNAs. MA587376 - JP 2018138019-A/159302: Polycomb-Associated Non-Coding RNAs. MA587377 - JP 2018138019-A/159303: Polycomb-Associated Non-Coding RNAs. MA587379 - JP 2018138019-A/159305: Polycomb-Associated Non-Coding RNAs. MA587385 - JP 2018138019-A/159311: Polycomb-Associated Non-Coding RNAs.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein Q9UNL2 (Reactome details) participates in the following event(s): R-HSA-1799326 Signal-containing nascent peptide translocates to endoplasmic reticulum R-HSA-1799329 Signal peptidase hydrolyzes signal peptide from ribosome-associated nascent protein R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane R-HSA-72766 Translation R-HSA-392499 Metabolism of proteins

Other Names for This Gene


	Alternate Gene Symbols: B2R7D0, B4E2P2, D3DNK5, ENST00000265044.1, ENST00000265044.2, ENST00000265044.3, ENST00000265044.4, ENST00000265044.5, ENST00000265044.6, NM_007107, Q549M4, Q9UNL2, SSRG_HUMAN, TRAPG, uc317hxx.1, uc317hxx.2 UCSC ID: ENST00000265044.7_6 RefSeq Accession: NM_007107.5 Protein: Q9UNL2 (aka SSRG_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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