Human Gene STAC (ENST00000273183.8_4) from GENCODE V47lift37

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Description: SH3 and cysteine rich domain, transcript variant 1 (from RefSeq NM_003149.3)
Gencode Transcript: ENST00000273183.8_4
Gencode Gene: ENSG00000144681.11_11
Transcript (Including UTRs)
Position: hg19 chr3:36,421,996-36,589,499 Size: 167,504 Total Exon Count: 11 Strand: +
Coding Region
Position: hg19 chr3:36,422,136-36,587,781 Size: 165,646 Coding Exon Count: 11

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr3:36,421,996-36,589,499)			mRNA (may differ from genome)		Protein (402 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	UniProtKB	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: STAC_HUMAN DESCRIPTION: RecName: Full=SH3 and cysteine-rich domain-containing protein; AltName: Full=Src homology 3 and cysteine-rich domain-containing protein; FUNCTION: Probably involved in a neuron-specific signal transduction. SUBCELLULAR LOCATION: Cytoplasm. SIMILARITY: Contains 1 phorbol-ester/DAG-type zinc finger. SIMILARITY: Contains 1 SH3 domain.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
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To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D001564 Benzo(a)pyrene D002922 Ciguatoxins D016572 Cyclosporine D008558 Melphalan C044887 beta-methylcholine C028031 cadmium acetate

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 6.74 RPKM in Artery - Aorta Total median expression: 55.52 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-64.50	140	-0.461	Picture	PostScript	Text
3' UTR	-514.30	1718	-0.299	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR002219 - Prot_Kinase_C-like_PE/DAG-bd
IPR011511 - SH3_2
IPR001452 - SH3_domain
IPR013315 - Spectrin_alpha_SH3

Pfam Domains:
PF00018 - SH3 domain
PF00130 - Phorbol esters/diacylglycerol binding domain (C1 domain)
PF07653 - Variant SH3 domain
PF14604 - Variant SH3 domain
PF16664 - Unstructured on SH3 and cysteine-rich domain-containing protein 2

SCOP Domains:
50044 - SH3-domain
57889 - Cysteine-rich domain
57903 - FYVE/PHD zinc finger

Protein Data Bank (PDB) 3-D Structure
MuPIT help

2DL4 - NMR MuPIT

ModBase Predicted Comparative 3D Structure on Q99469


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD	Ensembl

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0005515 protein binding GO:0044325 ion channel binding GO:0046872 metal ion binding Biological Process: GO:0006936 muscle contraction GO:0007165 signal transduction GO:0034605 cellular response to heat GO:0035556 intracellular signal transduction GO:1901385 regulation of voltage-gated calcium channel activity GO:1903078 positive regulation of protein localization to plasma membrane GO:2001259 positive regulation of cation channel activity Cellular Component: GO:0005737 cytoplasm GO:0005829 cytosol GO:0030315 T-tubule

Descriptions from all associated GenBank mRNAs


	AK313493 - Homo sapiens cDNA, FLJ94046, Homo sapiens src homology three (SH3) and cysteine rich domain(STAC), mRNA. BC020221 - Homo sapiens SH3 and cysteine rich domain, mRNA (cDNA clone MGC:31915 IMAGE:4589443), complete cds. AK299160 - Homo sapiens cDNA FLJ60332 complete cds, moderately similar to SH3 and cysteine-rich domain-containing protein. AK302697 - Homo sapiens cDNA FLJ54661 complete cds, highly similar to SH3 and cysteine-rich domain-containing protein. D86640 - Homo sapiens mRNA for stac, complete cds. DQ892180 - Synthetic construct clone IMAGE:100004810; FLH183747.01X; RZPDo839G02142D SH3 and cysteine rich domain (STAC) gene, encodes complete protein. DQ895374 - Synthetic construct Homo sapiens clone IMAGE:100009834; FLH183743.01L; RZPDo839G02141D SH3 and cysteine rich domain (STAC) gene, encodes complete protein. DQ895375 - Synthetic construct Homo sapiens clone IMAGE:100009835; FLH263689.01L; RZPDo839G03141D SH3 and cysteine rich domain (STAC) gene, encodes complete protein. AB529185 - Synthetic construct DNA, clone: pF1KE0692, Homo sapiens STAC gene for SH3 and cysteine rich domain-containing protein, without stop codon, in Flexi system. KJ897613 - Synthetic construct Homo sapiens clone ccsbBroadEn_07007 STAC gene, encodes complete protein. AK310425 - Homo sapiens cDNA, FLJ17467. AK056893 - Homo sapiens cDNA FLJ32331 fis, clone PROST2005093. JD473245 - Sequence 454269 from Patent EP1572962. JD310773 - Sequence 291797 from Patent EP1572962. JD338324 - Sequence 319348 from Patent EP1572962. JD424019 - Sequence 405043 from Patent EP1572962. JD241551 - Sequence 222575 from Patent EP1572962. JD082280 - Sequence 63304 from Patent EP1572962. JD547165 - Sequence 528189 from Patent EP1572962. JD252177 - Sequence 233201 from Patent EP1572962. JD196851 - Sequence 177875 from Patent EP1572962. JD123058 - Sequence 104082 from Patent EP1572962. JD200844 - Sequence 181868 from Patent EP1572962. JD123624 - Sequence 104648 from Patent EP1572962. JD375830 - Sequence 356854 from Patent EP1572962. JD372301 - Sequence 353325 from Patent EP1572962. JD528672 - Sequence 509696 from Patent EP1572962. JD107070 - Sequence 88094 from Patent EP1572962. JD400244 - Sequence 381268 from Patent EP1572962. JD273313 - Sequence 254337 from Patent EP1572962. JD486395 - Sequence 467419 from Patent EP1572962. JD060543 - Sequence 41567 from Patent EP1572962. JD064881 - Sequence 45905 from Patent EP1572962. JD068565 - Sequence 49589 from Patent EP1572962. JD498646 - Sequence 479670 from Patent EP1572962. JD484053 - Sequence 465077 from Patent EP1572962. JD147313 - Sequence 128337 from Patent EP1572962. JD292753 - Sequence 273777 from Patent EP1572962. JD094784 - Sequence 75808 from Patent EP1572962. JD131134 - Sequence 112158 from Patent EP1572962. JD334679 - Sequence 315703 from Patent EP1572962. JD507723 - Sequence 488747 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: B2R8S8, ENST00000273183.1, ENST00000273183.2, ENST00000273183.3, ENST00000273183.4, ENST00000273183.5, ENST00000273183.6, ENST00000273183.7, NM_003149, Q99469, STAC1 , STAC_HUMAN, uc317jbf.1, uc317jbf.2 UCSC ID: ENST00000273183.8_4 RefSeq Accession: NM_003149.3 Protein: Q99469 (aka STAC_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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