ID:STAM1_HUMAN DESCRIPTION: RecName: Full=Signal transducing adapter molecule 1; Short=STAM-1; FUNCTION: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. SUBUNIT: Component of the ESCRT-0 complex composed of STAM or STAM2 and HGS. Probably part of a complex at least composed of HSG, STAM and EPS15. Interacts with STAMBP/AMSH. Interacts with PDGFRB. INTERACTION: O95630:STAMBP; NbExp=3; IntAct=EBI-752333, EBI-396676; SUBCELLULAR LOCATION: Cytoplasm (Probable). Early endosome membrane; Peripheral membrane protein; Cytoplasmic side (Probable). TISSUE SPECIFICITY: Ubiquitously expressed. PTM: Phosphorylated on Tyr-198. Phosphorylated in response to IL2, IL3, IL4, IL7, CSF2/GM-CSF, EGF and PDGFB. Phosphorylated by activated PDGFRB. SIMILARITY: Belongs to the STAM family. SIMILARITY: Contains 1 ITAM domain. SIMILARITY: Contains 1 SH3 domain. SIMILARITY: Contains 1 UIM (ubiquitin-interacting motif) repeat. SIMILARITY: Contains 1 VHS domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q92783
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005070 SH3/SH2 adaptor activity GO:0005515 protein binding GO:0044389 ubiquitin-like protein ligase binding
Biological Process: GO:0006886 intracellular protein transport GO:0007165 signal transduction GO:0009967 positive regulation of signal transduction GO:0015031 protein transport GO:0016197 endosomal transport GO:0016236 macroautophagy GO:0016579 protein deubiquitination GO:0036258 multivesicular body assembly GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway GO:0061024 membrane organization GO:1903543 positive regulation of exosomal secretion GO:1903551 regulation of extracellular exosome assembly
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
