ID:STABP_HUMAN DESCRIPTION: RecName: Full=STAM-binding protein; EC=3.4.19.-; AltName: Full=Associated molecule with the SH3 domain of STAM; AltName: Full=Endosome-associated ubiquitin isopeptidase; FUNCTION: Zinc metalloprotease that specifically cleaves 'Lys-63'- linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Functions at the endosome and is able to oppose the ubiquitin-dependent sorting of receptors to lysosomes. Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7. COFACTOR: Binds 2 zinc ions per subunit (By similarity). ENZYME REGULATION: Inhibited by N-ethylmaleimide. SUBUNIT: Interacts with STAM1. Interacts with SMAD6 and SMAD7. Interacts with CHMP3; the interaction appears to relieve the autoinhibition of CHMP3. Interacts with SMURF2 and RNF11; this interaction promotes ubiquitination. INTERACTION: Q9HD42:CHMP1A; NbExp=3; IntAct=EBI-396676, EBI-1057156; Q7LBR1:CHMP1B; NbExp=5; IntAct=EBI-396676, EBI-2118090; Q9Y3E7:CHMP3; NbExp=5; IntAct=EBI-396676, EBI-2118119; Q9NZZ3:CHMP5; NbExp=2; IntAct=EBI-396676, EBI-751303; P62993:GRB2; NbExp=3; IntAct=EBI-396676, EBI-401755; Q9Y3C5:RNF11; NbExp=2; IntAct=EBI-396676, EBI-396669; O43541-2:SMAD6; NbExp=2; IntAct=EBI-396676, EBI-4324970; Q92783:STAM; NbExp=3; IntAct=EBI-396676, EBI-752333; O75886:STAM2; NbExp=3; IntAct=EBI-396676, EBI-373258; SUBCELLULAR LOCATION: Nucleus. Membrane; Peripheral membrane protein. Cytoplasm. Early endosome. TISSUE SPECIFICITY: Ubiquitously expressed. DOMAIN: The JAMM motif is essential for the protease activity (By similarity). PTM: Phosphorylated after BMP type I receptor activation. PTM: Ubiquitinated by SMURF2 in the presence of RNF11. MISCELLANEOUS: X-ray crystallography studies of STAMBPL1, another member of the peptidase M67C family, has shown that Glu-280 binds zinc indirectly via a water molecule. Nevertheless, this residue is essential for catalytic activity. SIMILARITY: Belongs to the peptidase M67C family. SIMILARITY: Contains 1 MPN (JAB/Mov34) domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O95630
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
