ID:STAP2_HUMAN DESCRIPTION: RecName: Full=Signal-transducing adaptor protein 2; Short=STAP-2; AltName: Full=Breast tumor kinase substrate; Short=BRK substrate; FUNCTION: Substrate of protein kinase PTK6. May play a regulatory role in the acute-phase response in systemic inflammation and may modulate STAT3 activity. SUBUNIT: Interacts with PTK6 and CSF1R. INTERACTION: O14920:IKBKB; NbExp=7; IntAct=EBI-1553984, EBI-81266; Q99836:MYD88; NbExp=3; IntAct=EBI-1553984, EBI-447677; SUBCELLULAR LOCATION: Cytoplasm. TISSUE SPECIFICITY: Widely expressed. PTM: Phosphorylated on tyrosine. Tyr-250 may be important for interaction with kinases. Phosphorylated by PTK6 at Tyr-250 modulates PTK6-mediated STAT3 activation. Tyr-22 and Tyr-322 appears to be phosphorylated by SRC. SIMILARITY: Contains 1 PH domain. SIMILARITY: Contains 1 SH2 domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UGK3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
