Human Gene STAT2 (ENST00000314128.9_12) from GENCODE V47lift37
  Description: signal transducer and activator of transcription 2, transcript variant 1 (from RefSeq NM_005419.4)
Gencode Transcript: ENST00000314128.9_12
Gencode Gene: ENSG00000170581.15_16
Transcript (Including UTRs)
   Position: hg19 chr12:56,735,381-56,753,891 Size: 18,511 Total Exon Count: 24 Strand: -
Coding Region
   Position: hg19 chr12:56,737,173-56,750,355 Size: 13,183 Coding Exon Count: 23 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureOther SpeciesmRNA DescriptionsPathways
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:56,735,381-56,753,891)mRNA (may differ from genome)Protein (851 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: STAT2
Diseases sorted by gene-association score: immunodeficiency 44* (919), primary immunodeficiency with post-measles-mumps-rubella vaccine viral infection* (750), mumps (37), rabies (13), skin squamous cell carcinoma (9), avian influenza (7), dengue hemorrhagic fever (7), microphthalmia with limb anomalies (5), measles (4)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • D001564 Benzo(a)pyrene
  • D013749 Tetrachlorodibenzodioxin
  • D014635 Valproic Acid
  • C006253 pirinixic acid
  • C111118 2',3,3',4',5-pentachloro-4-hydroxybiphenyl
  • D015081 2-Naphthylamine
  • C005975 3,4-dihydroxyphenylethanol
  • C009505 4,4'-diaminodiphenylmethane
  • C041398 7,7'-dimethoxy-(4,4'-bi-1,3-benzodioxole)-5,5'-dicarboxylic acid dimethyl ester
  • D000082 Acetaminophen
          more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 62.80 RPKM in Pituitary
Total median expression: 1361.17 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -13.2057-0.232 Picture PostScript Text
3' UTR -612.401792-0.342 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Descriptions from all associated GenBank mRNAs
  BX640607 - Homo sapiens mRNA; cDNA DKFZp686H05229 (from clone DKFZp686H05229).
BC051284 - Homo sapiens signal transducer and activator of transcription 2, 113kDa, mRNA (cDNA clone MGC:59816 IMAGE:6460486), complete cds.
AK094039 - Homo sapiens cDNA FLJ36720 fis, clone UTERU2011261.
M97934 - Homo sapiens interferon alpha induced transcriptional activator (ISGF-3) mRNA sequence.
JD566733 - Sequence 547757 from Patent EP1572962.
JD224922 - Sequence 205946 from Patent EP1572962.
JD240920 - Sequence 221944 from Patent EP1572962.
JD403642 - Sequence 384666 from Patent EP1572962.
JD202168 - Sequence 183192 from Patent EP1572962.
JD273837 - Sequence 254861 from Patent EP1572962.
JD432024 - Sequence 413048 from Patent EP1572962.
JD288554 - Sequence 269578 from Patent EP1572962.
AK296939 - Homo sapiens cDNA FLJ60293 complete cds, highly similar to Signal transducer and activator of transcription 2.
JD279161 - Sequence 260185 from Patent EP1572962.
DQ590269 - Homo sapiens piRNA piR-57381, complete sequence.
DQ590528 - Homo sapiens piRNA piR-57640, complete sequence.
JD506583 - Sequence 487607 from Patent EP1572962.
JD227277 - Sequence 208301 from Patent EP1572962.
JD537097 - Sequence 518121 from Patent EP1572962.
JD309795 - Sequence 290819 from Patent EP1572962.
JD026875 - Sequence 7899 from Patent EP1572962.
JD022185 - Sequence 3209 from Patent EP1572962.
JD434850 - Sequence 415874 from Patent EP1572962.
JD031409 - Sequence 12433 from Patent EP1572962.
JD031527 - Sequence 12551 from Patent EP1572962.
JD355829 - Sequence 336853 from Patent EP1572962.
JD350014 - Sequence 331038 from Patent EP1572962.
KJ892214 - Synthetic construct Homo sapiens clone ccsbBroadEn_01608 STAT2 gene, encodes complete protein.
AB384838 - Synthetic construct DNA, clone: pF1KB3699, Homo sapiens STAT2 gene for signal transducer and activator of transcription 2, complete cds, without stop codon, in Flexi system.
BC006092 - Homo sapiens signal transducer and activator of transcription 2, 113kDa, mRNA (cDNA clone IMAGE:4054862), partial cds.
AK308051 - Homo sapiens cDNA, FLJ97999.
AK296940 - Homo sapiens cDNA FLJ59331 complete cds, highly similar to Signal transducer and activator of transcription 2.
AK316516 - Homo sapiens cDNA, FLJ79415 complete cds, highly similar to Signal transducer and activator of transcription 2.
AK295114 - Homo sapiens cDNA FLJ50517 complete cds, moderately similar to Signal transducer and activator of transcription 2.
AK295052 - Homo sapiens cDNA FLJ56695 complete cds, highly similar to Signal transducer and activator of transcription 2.
AK310727 - Homo sapiens cDNA, FLJ17769.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_ifnaPathway - IFN alpha signaling pathway

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000314128.1, ENST00000314128.2, ENST00000314128.3, ENST00000314128.4, ENST00000314128.5, ENST00000314128.6, ENST00000314128.7, ENST00000314128.8, hCG_24995 , NM_005419, R9QE65, R9QE65_HUMAN, STAT2 , uc317pny.1, uc317pny.2
UCSC ID: ENST00000314128.9_12
RefSeq Accession: NM_005419.4

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.