Human Gene STC1 (ENST00000290271.7_7) from GENCODE V47lift37
  Description: stanniocalcin 1 (from RefSeq NM_003155.3)
Gencode Transcript: ENST00000290271.7_7
Gencode Gene: ENSG00000159167.12_9
Transcript (Including UTRs)
   Position: hg19 chr8:23,699,442-23,712,319 Size: 12,878 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg19 chr8:23,702,283-23,712,036 Size: 9,754 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr8:23,699,442-23,712,319)mRNA (may differ from genome)Protein (247 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: STC1_HUMAN
DESCRIPTION: RecName: Full=Stanniocalcin-1; Short=STC-1; Flags: Precursor;
FUNCTION: Stimulates renal phosphate reabsorption, and could therefore prevent hypercalcemia.
SUBUNIT: Homodimer; disulfide-linked (By similarity).
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Expressed in most tissues, with the highest levels in ovary, prostate, heart, kidney and thyroid. In the kidney, expression is confined to the nephron, specifically in the distal convoluted tubule and in the collecting tubule. Not detected in the brain, liver, spleen, peripheral blood leukocytes and adrenal medulla.
SIMILARITY: Belongs to the stanniocalcin family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: STC1
Diseases sorted by gene-association score: diverticulitis of colon (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • D011374 Progesterone
  • D003993 Dibutyl Phthalate
  • D019833 Genistein
  • D013749 Tetrachlorodibenzodioxin
  • D020122 tert-Butylhydroperoxide
  • C015559 trimellitic anhydride
  • C015262 1,6-hexamethylene diisocyanate
  • C422565 13beta-methyl 19-nor-steroid
  • C111118 2',3,3',4',5-pentachloro-4-hydroxybiphenyl
  • C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester
          more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 22.45 RPKM in Thyroid
Total median expression: 163.39 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -78.30283-0.277 Picture PostScript Text
3' UTR -717.302841-0.252 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR004978 - Stanniocalcin

Pfam Domains:
PF03298 - Stanniocalcin family

ModBase Predicted Comparative 3D Structure on P52823
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005179 hormone activity

Biological Process:
GO:0001503 ossification
GO:0001886 endothelial cell morphogenesis
GO:0003421 growth plate cartilage axis specification
GO:0006874 cellular calcium ion homeostasis
GO:0007566 embryo implantation
GO:0010469 regulation of receptor activity
GO:0010596 negative regulation of endothelial cell migration
GO:0014070 response to organic cyclic compound
GO:0030336 negative regulation of cell migration
GO:0033280 response to vitamin D
GO:0035988 chondrocyte proliferation
GO:0044070 regulation of anion transport
GO:0046697 decidualization
GO:0051926 negative regulation of calcium ion transport
GO:0060348 bone development
GO:0071320 cellular response to cAMP
GO:0071385 cellular response to glucocorticoid stimulus
GO:0071456 cellular response to hypoxia
GO:0086004 regulation of cardiac muscle cell contraction
GO:0090280 positive regulation of calcium ion import
GO:1903403 negative regulation of renal phosphate excretion

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016324 apical plasma membrane


-  Descriptions from all associated GenBank mRNAs
  LF210138 - JP 2014500723-A/17641: Polycomb-Associated Non-Coding RNAs.
S50179 - {clone S1} [human, 76N, mammary epithelial cells, mRNA, 607 nt].
U25997 - Homo sapiens stanniocalcin precursor (STC) mRNA, complete cds.
S50184 - {3' region, probe S1} [human, 76N, mammary epithelial cells, mRNA Partial, 177 nt].
JD510741 - Sequence 491765 from Patent EP1572962.
LF335077 - JP 2014500723-A/142580: Polycomb-Associated Non-Coding RNAs.
JD262722 - Sequence 243746 from Patent EP1572962.
JD273549 - Sequence 254573 from Patent EP1572962.
JD098963 - Sequence 79987 from Patent EP1572962.
LF335075 - JP 2014500723-A/142578: Polycomb-Associated Non-Coding RNAs.
JD122973 - Sequence 103997 from Patent EP1572962.
JD061054 - Sequence 42078 from Patent EP1572962.
LF335074 - JP 2014500723-A/142577: Polycomb-Associated Non-Coding RNAs.
JD284767 - Sequence 265791 from Patent EP1572962.
JD370342 - Sequence 351366 from Patent EP1572962.
JD451270 - Sequence 432294 from Patent EP1572962.
JD339599 - Sequence 320623 from Patent EP1572962.
JD256049 - Sequence 237073 from Patent EP1572962.
JD471321 - Sequence 452345 from Patent EP1572962.
JD077612 - Sequence 58636 from Patent EP1572962.
JD445030 - Sequence 426054 from Patent EP1572962.
JD491646 - Sequence 472670 from Patent EP1572962.
JD281267 - Sequence 262291 from Patent EP1572962.
LF335073 - JP 2014500723-A/142576: Polycomb-Associated Non-Coding RNAs.
JD072563 - Sequence 53587 from Patent EP1572962.
JD444634 - Sequence 425658 from Patent EP1572962.
JD037693 - Sequence 18717 from Patent EP1572962.
BC029044 - Homo sapiens stanniocalcin 1, mRNA (cDNA clone MGC:34539 IMAGE:5191420), complete cds.
JD465775 - Sequence 446799 from Patent EP1572962.
JD082402 - Sequence 63426 from Patent EP1572962.
JD284246 - Sequence 265270 from Patent EP1572962.
JD518322 - Sequence 499346 from Patent EP1572962.
JD095721 - Sequence 76745 from Patent EP1572962.
AK297734 - Homo sapiens cDNA FLJ51498 complete cds, highly similar to Stanniocalcin-1 precursor.
AK309366 - Homo sapiens cDNA, FLJ99407.
JD428805 - Sequence 409829 from Patent EP1572962.
JD174324 - Sequence 155348 from Patent EP1572962.
LF335072 - JP 2014500723-A/142575: Polycomb-Associated Non-Coding RNAs.
JD558923 - Sequence 539947 from Patent EP1572962.
JD564644 - Sequence 545668 from Patent EP1572962.
JD382397 - Sequence 363421 from Patent EP1572962.
JD448015 - Sequence 429039 from Patent EP1572962.
JD292001 - Sequence 273025 from Patent EP1572962.
JD132158 - Sequence 113182 from Patent EP1572962.
LF335071 - JP 2014500723-A/142574: Polycomb-Associated Non-Coding RNAs.
LF335070 - JP 2014500723-A/142573: Polycomb-Associated Non-Coding RNAs.
JD300005 - Sequence 281029 from Patent EP1572962.
LF335068 - JP 2014500723-A/142571: Polycomb-Associated Non-Coding RNAs.
JD228971 - Sequence 209995 from Patent EP1572962.
JD251673 - Sequence 232697 from Patent EP1572962.
U46768 - Human stanniocalcin mRNA, complete cds.
JD175364 - Sequence 156388 from Patent EP1572962.
KP455655 - Homo sapiens stanniocalcin 1 (stc1) mRNA, complete cds, alternatively spliced.
KP455656 - Homo sapiens stanniocalcin 1 (stc1) mRNA, complete cds, alternatively spliced.
KP455657 - Homo sapiens stanniocalcin 1 (stc1) mRNA, complete cds, alternatively spliced.
KP455659 - Homo sapiens stanniocalcin 1 (stc1) mRNA, complete cds, alternatively spliced.
JD056969 - Sequence 37993 from Patent EP1572962.
KP455658 - Homo sapiens stanniocalcin 1 (stc1) mRNA, complete cds, alternatively spliced.
KJ897615 - Synthetic construct Homo sapiens clone ccsbBroadEn_07009 STC1 gene, encodes complete protein.
AK312589 - Homo sapiens cDNA, FLJ92965, highly similar to Homo sapiens stanniocalcin 1 (STC1), mRNA.
DQ890813 - Synthetic construct clone IMAGE:100003443; FLH166140.01X; RZPDo839D0486D stanniocalcin 1 (STC1) gene, encodes complete protein.
DQ893968 - Synthetic construct Homo sapiens clone IMAGE:100008428; FLH166136.01L; RZPDo839D0485D stanniocalcin 1 (STC1) gene, encodes complete protein.
LF335066 - JP 2014500723-A/142569: Polycomb-Associated Non-Coding RNAs.
LF335061 - JP 2014500723-A/142564: Polycomb-Associated Non-Coding RNAs.
LF335060 - JP 2014500723-A/142563: Polycomb-Associated Non-Coding RNAs.
LF335059 - JP 2014500723-A/142562: Polycomb-Associated Non-Coding RNAs.
LF335058 - JP 2014500723-A/142561: Polycomb-Associated Non-Coding RNAs.
JD115261 - Sequence 96285 from Patent EP1572962.
JD382752 - Sequence 363776 from Patent EP1572962.
JD056539 - Sequence 37563 from Patent EP1572962.
JD131965 - Sequence 112989 from Patent EP1572962.
JD396311 - Sequence 377335 from Patent EP1572962.
JD370507 - Sequence 351531 from Patent EP1572962.
JD186824 - Sequence 167848 from Patent EP1572962.
JD186853 - Sequence 167877 from Patent EP1572962.
MA445715 - JP 2018138019-A/17641: Polycomb-Associated Non-Coding RNAs.
MA570654 - JP 2018138019-A/142580: Polycomb-Associated Non-Coding RNAs.
MA570652 - JP 2018138019-A/142578: Polycomb-Associated Non-Coding RNAs.
MA570651 - JP 2018138019-A/142577: Polycomb-Associated Non-Coding RNAs.
MA570650 - JP 2018138019-A/142576: Polycomb-Associated Non-Coding RNAs.
MA570649 - JP 2018138019-A/142575: Polycomb-Associated Non-Coding RNAs.
MA570648 - JP 2018138019-A/142574: Polycomb-Associated Non-Coding RNAs.
MA570647 - JP 2018138019-A/142573: Polycomb-Associated Non-Coding RNAs.
MA570645 - JP 2018138019-A/142571: Polycomb-Associated Non-Coding RNAs.
MA570643 - JP 2018138019-A/142569: Polycomb-Associated Non-Coding RNAs.
MA570638 - JP 2018138019-A/142564: Polycomb-Associated Non-Coding RNAs.
MA570637 - JP 2018138019-A/142563: Polycomb-Associated Non-Coding RNAs.
MA570636 - JP 2018138019-A/142562: Polycomb-Associated Non-Coding RNAs.
MA570635 - JP 2018138019-A/142561: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: B4DN22, ENST00000290271.1, ENST00000290271.2, ENST00000290271.3, ENST00000290271.4, ENST00000290271.5, ENST00000290271.6, NM_003155, P52823, Q71UE5, STC, STC1_HUMAN, uc317kug.1, uc317kug.2
UCSC ID: ENST00000290271.7_7
RefSeq Accession: NM_003155.3
Protein: P52823 (aka STC1_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.