ID:STK16_HUMAN DESCRIPTION: RecName: Full=Serine/threonine-protein kinase 16; EC=2.7.11.1; AltName: Full=Myristoylated and palmitoylated serine/threonine-protein kinase; Short=MPSK; AltName: Full=Protein kinase PKL12; AltName: Full=TGF-beta-stimulated factor 1; Short=TSF-1; AltName: Full=Tyrosine-protein kinase STK16; EC=2.7.10.2; AltName: Full=hPSK; FUNCTION: Membrane-associated protein kinase that phosphorylates on serine and threonine residues. In vitro substrates include DRG1, ENO1 and EIF4EBP1. Also autophosphorylates. May be involved in secretory vesicle trafficking or intracellular signaling. May have a role in regulating stromal-epithelial interactions that occur during ductal morphogenesis in the mammary gland. May be involved in TGF-beta signaling. Able to autophosphorylate on Tyr residue; it is however unclear whether it has tyrosine-protein kinase toward other proteins. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. SUBUNIT: Monomer. Interacts with DRG1 (via its N-terminal); the interaction phosphorylates DRG1. INTERACTION: Q6UY14:ADAMTSL4; NbExp=3; IntAct=EBI-749295, EBI-742002; SUBCELLULAR LOCATION: Cytoplasm, perinuclear region. Membrane; Lipid-anchor (By similarity). Note=Associates with Golgi and Golgi-derived vesicles (By similarity). TISSUE SPECIFICITY: Ubiquitously expressed at very low levels. PTM: Mainly autophosphorylated on serine/threonine residues. Also autophosphorylated on Tyr-198. PTM: It is uncertain whether palmitoylation is on Cys-6 and/or Cys-8. SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. SIMILARITY: Contains 1 protein kinase domain. SEQUENCE CAUTION: Sequence=AAV38392.1; Type=Frameshift; Positions=305; Sequence=CAA06700.1; Type=Frameshift; Positions=305;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O75716
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000166 nucleotide binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0004672 protein kinase activity GO:0004674 protein serine/threonine kinase activity GO:0004715 non-membrane spanning protein tyrosine kinase activity GO:0005515 protein binding GO:0005524 ATP binding GO:0016301 kinase activity GO:0016740 transferase activity
Biological Process: GO:0006366 transcription from RNA polymerase II promoter GO:0006468 protein phosphorylation GO:0016310 phosphorylation GO:0018108 peptidyl-tyrosine phosphorylation GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0046777 protein autophosphorylation GO:0071560 cellular response to transforming growth factor beta stimulus
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
