Human Gene STK19 (ENST00000685781.1_5) from GENCODE V47lift37
  Description: serine/threonine kinase 19, transcript variant 1 (from RefSeq NM_004197.2)
Gencode Transcript: ENST00000685781.1_5
Gencode Gene: ENSG00000204344.16_14
Transcript (Including UTRs)
   Position: hg19 chr6:31,940,140-31,949,223 Size: 9,084 Total Exon Count: 7 Strand: +
Coding Region
   Position: hg19 chr6:31,940,189-31,948,826 Size: 8,638 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:31,940,140-31,949,223)mRNA (may differ from genome)Protein (254 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: STK19_HUMAN
DESCRIPTION: RecName: Full=Serine/threonine-protein kinase 19; EC=2.7.11.1; AltName: Full=Protein G11; AltName: Full=Protein RP1;
FUNCTION: Seems to be a protein kinase. In vitro it can phosphorylate casein-alpha on serine and threonine residues and histones on serine residues.
CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
COFACTOR: Divalent cations. Has a preference for manganese.
SUBUNIT: The N-terminus interacts with BAG1.
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: Monocytes, hepatocytes, epithelial cells, T- and B-lymphocytes.
SIMILARITY: Belongs to the STK19 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -8.1049-0.165 Picture PostScript Text
3' UTR -130.30397-0.328 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR018865 - Ser/Thr_kinase_19

Pfam Domains:
PF10494 - Serine-threonine protein kinase 19

ModBase Predicted Comparative 3D Structure on P49842
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
  Ensembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity

Biological Process:
GO:0006468 protein phosphorylation
GO:0016310 phosphorylation

Cellular Component:
GO:0005634 nucleus
GO:0016607 nuclear speck


-  Descriptions from all associated GenBank mRNAs
  AK302111 - Homo sapiens cDNA FLJ54971 complete cds, moderately similar to Serine/threonine-protein kinase 19 (EC 2.7.11.1).
BC110347 - Homo sapiens serine/threonine kinase 19, mRNA (cDNA clone MGC:117388 IMAGE:5165123), complete cds.
AK303438 - Homo sapiens cDNA FLJ61515 complete cds, highly similar to Serine/threonine-protein kinase 19 (EC2.7.11.1).
L26260 - Homo sapiens RP protein (RP) mRNA, complete cds.
BC143833 - Homo sapiens serine/threonine kinase 19, mRNA (cDNA clone MGC:177365 IMAGE:9052348), complete cds.
BC143835 - Homo sapiens cDNA clone IMAGE:9052350.
BC121128 - Homo sapiens serine/threonine kinase 19, mRNA (cDNA clone MGC:150441 IMAGE:40120738), complete cds.
BC121129 - Homo sapiens serine/threonine kinase 19, mRNA (cDNA clone MGC:150442 IMAGE:40120740), complete cds.
BC016916 - Homo sapiens cDNA clone IMAGE:4400551, containing frame-shift errors.
KJ900836 - Synthetic construct Homo sapiens clone ccsbBroadEn_10230 STK19 gene, encodes complete protein.
X77386 - H.sapiens G11 mRNA.
AK307198 - Homo sapiens cDNA, FLJ97146.
DQ596449 - Homo sapiens piRNA piR-34515, complete sequence.
JD052605 - Sequence 33629 from Patent EP1572962.
JD176357 - Sequence 157381 from Patent EP1572962.
JD318452 - Sequence 299476 from Patent EP1572962.
JD045256 - Sequence 26280 from Patent EP1572962.
JD527101 - Sequence 508125 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A6NF95, A6NFW8, B0QZR5, G11 , NM_004197, P49842, Q13159, Q31617, Q5JP77, Q5ST72, Q5ST75, RP1 , STK19 , STK19_HUMAN, uc330orb.1, uc330orb.2
UCSC ID: ENST00000685781.1_5
RefSeq Accession: NM_004197.2
Protein: P49842 (aka STK19_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.