ID:STK24_HUMAN DESCRIPTION: RecName: Full=Serine/threonine-protein kinase 24; EC=2.7.11.1; AltName: Full=Mammalian STE20-like protein kinase 3; Short=MST-3; AltName: Full=STE20-like kinase MST3; Contains: RecName: Full=Serine/threonine-protein kinase 24 36 kDa subunit; AltName: Full=Mammalian STE20-like protein kinase 3 N-terminal; Short=MST3/N; Contains: RecName: Full=Serine/threonine-protein kinase 24 12 kDa subunit; AltName: Full=Mammalian STE20-like protein kinase 3 C-terminal; Short=MST3/C; FUNCTION: Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress- induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase- independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. Regulates cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. COFACTOR: Magnesium, manganese, cobalt and zinc. BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=12.8 uM for manganese ions; KM=34.9 uM for cobalt ions; KM=22.7 uM for magnesium ions; KM=4.1 uM for zinc ions; Vmax=2623.1 pmol/min/mg enzyme for manganese ions; Vmax=1746.1 pmol/min/mg enzyme for cobalt ions; Vmax=129.1 pmol/min/mg enzyme for magnesium ions; Vmax=22.3 pmol/min/mg enzyme for zinc ions; SUBUNIT: Monomer. INTERACTION: Q9P2B4:CTTNBP2NL; NbExp=3; IntAct=EBI-740175, EBI-1774273; Q9BUL8:PDCD10; NbExp=4; IntAct=EBI-740175, EBI-740195; O43815:STRN; NbExp=2; IntAct=EBI-740175, EBI-1046642; Q9Y228:TRAF3IP3; NbExp=2; IntAct=EBI-740175, EBI-765817; SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Membrane. Note=The truncated form (MST3/N) translocates to the nucleus. Co-localizes with STK38L in the membrane. TISSUE SPECIFICITY: Isoform A is ubiquitous. Isoform B is expressed in brain with high expression in hippocampus and cerebral cortex. PTM: Proteolytically processed by caspases during apoptosis. Proteolytic cleavage results in kinase activation, nuclear translocation of the truncated form (MST3/N) and the induction of apoptosis. PTM: Isoform B is activated by phosphorylation by PKA. Oxidative stress induces phosphorylation. Activated by autophosphorylation at Thr-190 and phosphorylation at this site is essential for its function. Manganese, magnesium and cobalt-dependent autophosphorylation is mainly on threonine residues while zinc- dependent autophosphorylation is on both serine and threonine residues. SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. SIMILARITY: Contains 1 protein kinase domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9Y6E0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
