Human Gene STK31 (ENST00000355870.8_11) from GENCODE V47lift37
  Description: serine/threonine kinase 31, transcript variant 3 (from RefSeq NR_048542.2)
Gencode Transcript: ENST00000355870.8_11
Gencode Gene: ENSG00000196335.13_15
Transcript (Including UTRs)
   Position: hg19 chr7:23,749,838-23,872,132 Size: 122,295 Total Exon Count: 24 Strand: +
Coding Region
   Position: hg19 chr7:23,749,905-23,871,985 Size: 122,081 Coding Exon Count: 24 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:23,749,838-23,872,132)mRNA (may differ from genome)Protein (1019 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: STK31_HUMAN
DESCRIPTION: RecName: Full=Serine/threonine-protein kinase 31; EC=2.7.11.1; AltName: Full=Serine/threonine-protein kinase NYD-SPK; AltName: Full=Sugen kinase 396; Short=SgK396;
CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
TISSUE SPECIFICITY: Testis specific.
SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
SIMILARITY: Contains 1 protein kinase domain.
SIMILARITY: Contains 1 Tudor domain.
CAUTION: Ser-854 is present instead of the conserved Asp which is expected to be an active site residue.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 35.88 RPKM in Testis
Total median expression: 43.93 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -24.4067-0.364 Picture PostScript Text
3' UTR -23.30147-0.159 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011009 - Kinase-like_dom
IPR000719 - Prot_kinase_cat_dom
IPR002999 - Tudor

Pfam Domains:
PF00069 - Protein kinase domain
PF00567 - Tudor domain
PF07714 - Protein tyrosine and serine/threonine kinase

SCOP Domains:
63748 - Tudor/PWWP/MBT
50199 - Staphylococcal nuclease
56112 - Protein kinase-like (PK-like)

ModBase Predicted Comparative 3D Structure on Q9BXU1
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0004518 nuclease activity
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity

Biological Process:
GO:0006401 RNA catabolic process
GO:0006468 protein phosphorylation
GO:0016310 phosphorylation
GO:0090305 nucleic acid phosphodiester bond hydrolysis

Cellular Component:
GO:0001669 acrosomal vesicle
GO:0005634 nucleus
GO:0005737 cytoplasm


-  Descriptions from all associated GenBank mRNAs
  HM005701 - Homo sapiens clone HTL-T-78m testis tissue sperm-binding protein Li 78m mRNA, complete cds.
LF384110 - JP 2014500723-A/191613: Polycomb-Associated Non-Coding RNAs.
BC059374 - Homo sapiens serine/threonine kinase 31, mRNA (cDNA clone MGC:71599 IMAGE:5268051), complete cds.
BC033018 - Homo sapiens serine/threonine kinase 31, mRNA (cDNA clone IMAGE:4839162).
AF285599 - Homo sapiens serine/threonine kinase 31 (STK31) mRNA, complete cds.
AK292474 - Homo sapiens cDNA FLJ78627 complete cds, highly similar to Homo sapiens serine/threonine kinase 31, transcript variant 1, mRNA.
AK302689 - Homo sapiens cDNA FLJ60073 complete cds, highly similar to Serine/threonine-protein kinase 31 (EC 2.7.11.1).
AF332194 - Homo sapiens protein kinase NYD-SPK mRNA, complete cds.
BC036476 - Homo sapiens cDNA clone IMAGE:5259302, containing frame-shift errors.
AK131214 - Homo sapiens cDNA FLJ16102 fis, clone TESTI2015335, highly similar to Serine/threonine-protein kinase 31 (EC 2.7.11.1).
AK057430 - Homo sapiens cDNA FLJ32868 fis, clone TESTI2003781.
MA619687 - JP 2018138019-A/191613: Polycomb-Associated Non-Coding RNAs.
AK057271 - Homo sapiens cDNA FLJ32709 fis, clone TESTI2000695, weakly similar to KINESIN HEAVY CHAIN.
BC047506 - Homo sapiens cDNA clone IMAGE:5295088, containing frame-shift errors.
LF362328 - JP 2014500723-A/169831: Polycomb-Associated Non-Coding RNAs.
LF362330 - JP 2014500723-A/169833: Polycomb-Associated Non-Coding RNAs.
JD033486 - Sequence 14510 from Patent EP1572962.
LF362331 - JP 2014500723-A/169834: Polycomb-Associated Non-Coding RNAs.
LF362335 - JP 2014500723-A/169838: Polycomb-Associated Non-Coding RNAs.
AK095805 - Homo sapiens cDNA FLJ38486 fis, clone FEBRA2023351.
MA597905 - JP 2018138019-A/169831: Polycomb-Associated Non-Coding RNAs.
MA597907 - JP 2018138019-A/169833: Polycomb-Associated Non-Coding RNAs.
MA597908 - JP 2018138019-A/169834: Polycomb-Associated Non-Coding RNAs.
MA597912 - JP 2018138019-A/169838: Polycomb-Associated Non-Coding RNAs.
JD234893 - Sequence 215917 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B4DZ06, B7WPP5, C9J4F9, ENST00000355870.1, ENST00000355870.2, ENST00000355870.3, ENST00000355870.4, ENST00000355870.5, ENST00000355870.6, ENST00000355870.7, NR_048542, Q6PCD3, Q9BXH8, Q9BXU1, SGK396, STK31_HUMAN, uc317zhl.1, uc317zhl.2
UCSC ID: ENST00000355870.8_11
RefSeq Accession: NM_031414.5
Protein: Q9BXU1 (aka STK31_HUMAN or ST31_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.