Human Gene STK40 (ENST00000373132.4_14) from GENCODE V47lift37
  Description: serine/threonine kinase 40, transcript variant 2 (from RefSeq NM_001282547.2)
Gencode Transcript: ENST00000373132.4_14
Gencode Gene: ENSG00000196182.11_15
Transcript (Including UTRs)
   Position: hg19 chr1:36,805,229-36,851,525 Size: 46,297 Total Exon Count: 11 Strand: -
Coding Region
   Position: hg19 chr1:36,807,356-36,826,933 Size: 19,578 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:36,805,229-36,851,525)mRNA (may differ from genome)Protein (435 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: STK40_HUMAN
DESCRIPTION: RecName: Full=Serine/threonine-protein kinase 40; EC=2.7.11.1; AltName: Full=SINK-homologous serine/threonine-protein kinase; AltName: Full=Sugen kinase 495; Short=SgK495;
FUNCTION: May be a negative regulator of NF-kappa-B and p53- mediated gene transcription.
CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
SUBCELLULAR LOCATION: Nucleus. Cytoplasm.
TISSUE SPECIFICITY: Strongly expressed in heart, brain, placenta, lung, skeletal muscle, kidney, spleen, thymus, prostate, liver, pancreas, testis, ovary, small intestine, colon and peripheral blood leukocytes.
SIMILARITY: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
SIMILARITY: Contains 1 protein kinase domain.
SEQUENCE CAUTION: Sequence=AAH08344.1; Type=Erroneous initiation; Sequence=BAB15794.1; Type=Erroneous initiation; Sequence=BAC11361.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 41.09 RPKM in Whole Blood
Total median expression: 785.59 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -112.60210-0.536 Picture PostScript Text
3' UTR -817.742127-0.384 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011009 - Kinase-like_dom
IPR000719 - Prot_kinase_cat_dom
IPR024236 - Ser/Thr_kinase_40
IPR008271 - Ser/Thr_kinase_AS
IPR024104 - Tribbles/Ser_Thr_kinase_40

Pfam Domains:
PF00069 - Protein kinase domain
PF07714 - Protein tyrosine and serine/threonine kinase

SCOP Domains:
56112 - Protein kinase-like (PK-like)

ModBase Predicted Comparative 3D Structure on Q8N2I9
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity

Biological Process:
GO:0003016 respiratory system process
GO:0005977 glycogen metabolic process
GO:0006468 protein phosphorylation
GO:0010468 regulation of gene expression
GO:0016310 phosphorylation
GO:0030324 lung development
GO:0035264 multicellular organism growth
GO:0043066 negative regulation of apoptotic process
GO:0043408 regulation of MAPK cascade
GO:0048286 lung alveolus development
GO:0060425 lung morphogenesis

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol


-  Descriptions from all associated GenBank mRNAs
  AL834137 - Homo sapiens mRNA; cDNA DKFZp762O044 (from clone DKFZp762O044).
BC008344 - Homo sapiens serine/threonine kinase 40, mRNA (cDNA clone MGC:15888 IMAGE:3530483), complete cds.
BC007835 - Homo sapiens serine/threonine kinase 40, mRNA (cDNA clone MGC:14160 IMAGE:4109652), complete cds.
AY198395 - Homo sapiens Ser/Thr-like kinase mRNA, complete cds.
AK075048 - Homo sapiens cDNA FLJ90567 fis, clone OVARC1001569, weakly similar to PROBABLE SERINE/THREONINE-PROTEIN KINASE YKL101W (EC 2.7.1.-).
AK075029 - Homo sapiens cDNA FLJ90548 fis, clone OVARC1000529, weakly similar to PROBABLE SERINE/THREONINE-PROTEIN KINASE YKL101W (EC 2.7.1.-).
AK000808 - Homo sapiens cDNA FLJ20801 fis, clone ADSU01303.
AK131560 - Homo sapiens cDNA FLJ16807 fis, clone TESTI4052089.
BC005169 - Homo sapiens serine/threonine kinase 40, mRNA (cDNA clone IMAGE:3544659), partial cds.
AK024504 - Homo sapiens mRNA for FLJ00113 protein, partial cds.
JD358112 - Sequence 339136 from Patent EP1572962.
JD136677 - Sequence 117701 from Patent EP1572962.
JD467389 - Sequence 448413 from Patent EP1572962.
JD442864 - Sequence 423888 from Patent EP1572962.
JD477601 - Sequence 458625 from Patent EP1572962.
JD536876 - Sequence 517900 from Patent EP1572962.
JD217358 - Sequence 198382 from Patent EP1572962.
JD100494 - Sequence 81518 from Patent EP1572962.
JD269822 - Sequence 250846 from Patent EP1572962.
JD383184 - Sequence 364208 from Patent EP1572962.
JD459956 - Sequence 440980 from Patent EP1572962.
JD465234 - Sequence 446258 from Patent EP1572962.
JD331295 - Sequence 312319 from Patent EP1572962.
JD255229 - Sequence 236253 from Patent EP1572962.
JD192588 - Sequence 173612 from Patent EP1572962.
JD210459 - Sequence 191483 from Patent EP1572962.
JD111910 - Sequence 92934 from Patent EP1572962.
JD118720 - Sequence 99744 from Patent EP1572962.
JD521282 - Sequence 502306 from Patent EP1572962.
JD134461 - Sequence 115485 from Patent EP1572962.
JD560603 - Sequence 541627 from Patent EP1572962.
JD429316 - Sequence 410340 from Patent EP1572962.
JD292974 - Sequence 273998 from Patent EP1572962.
JD119734 - Sequence 100758 from Patent EP1572962.
JD052151 - Sequence 33175 from Patent EP1572962.
DQ588340 - Homo sapiens piRNA piR-55452, complete sequence.
JD326163 - Sequence 307187 from Patent EP1572962.
JD485706 - Sequence 466730 from Patent EP1572962.
JD221104 - Sequence 202128 from Patent EP1572962.
JD545314 - Sequence 526338 from Patent EP1572962.
JD554820 - Sequence 535844 from Patent EP1572962.
JD498893 - Sequence 479917 from Patent EP1572962.
JD479329 - Sequence 460353 from Patent EP1572962.
JD258650 - Sequence 239674 from Patent EP1572962.
JD391415 - Sequence 372439 from Patent EP1572962.
JD121328 - Sequence 102352 from Patent EP1572962.
JD157301 - Sequence 138325 from Patent EP1572962.
JD366899 - Sequence 347923 from Patent EP1572962.
JD209243 - Sequence 190267 from Patent EP1572962.
JD378694 - Sequence 359718 from Patent EP1572962.
JD378695 - Sequence 359719 from Patent EP1572962.
JD566409 - Sequence 547433 from Patent EP1572962.
JD269377 - Sequence 250401 from Patent EP1572962.
JD519724 - Sequence 500748 from Patent EP1572962.
JD388615 - Sequence 369639 from Patent EP1572962.
JD104027 - Sequence 85051 from Patent EP1572962.
JD135158 - Sequence 116182 from Patent EP1572962.
JD426246 - Sequence 407270 from Patent EP1572962.
JD277458 - Sequence 258482 from Patent EP1572962.
JD475141 - Sequence 456165 from Patent EP1572962.
JD242058 - Sequence 223082 from Patent EP1572962.
JD395647 - Sequence 376671 from Patent EP1572962.
JD209130 - Sequence 190154 from Patent EP1572962.
JD408817 - Sequence 389841 from Patent EP1572962.
KJ903368 - Synthetic construct Homo sapiens clone ccsbBroadEn_12762 STK40 gene, encodes complete protein.
AM392535 - Synthetic construct Homo sapiens clone IMAGE:100003035 for hypothetical protein (STK40 gene).
AM392597 - Synthetic construct Homo sapiens clone IMAGE:100003036 for hypothetical protein (STK40 gene).
AM392953 - Synthetic construct Homo sapiens clone IMAGE:100003048 for hypothetical protein (STK40 gene).
AM392969 - Synthetic construct Homo sapiens clone IMAGE:100003047 for hypothetical protein (STK40 gene).
KJ894914 - Synthetic construct Homo sapiens clone ccsbBroadEn_04308 STK40 gene, encodes complete protein.
KJ905569 - Synthetic construct Homo sapiens clone ccsbBroadEn_15186 STK40 gene, encodes complete protein.
AB463251 - Synthetic construct DNA, clone: pF1KB8429, Homo sapiens STK40 gene for serine/threonine kinase 40, without stop codon, in Flexi system.
AM392520 - Synthetic construct Homo sapiens clone IMAGE:100002777 for hypothetical protein (STK40 gene).
AM392770 - Synthetic construct Homo sapiens clone IMAGE:100002791 for hypothetical protein (STK40 gene).
AM392852 - Synthetic construct Homo sapiens clone IMAGE:100002778 for hypothetical protein (STK40 gene).
AM393274 - Synthetic construct Homo sapiens clone IMAGE:100002792 for hypothetical protein (STK40 gene).
JD399094 - Sequence 380118 from Patent EP1572962.
JD191977 - Sequence 173001 from Patent EP1572962.
JD460554 - Sequence 441578 from Patent EP1572962.
AK023810 - Homo sapiens cDNA FLJ13748 fis, clone PLACE3000310.
CU675823 - Synthetic construct Homo sapiens gateway clone IMAGE:100019385 5' read STK40 mRNA.
DQ589231 - Homo sapiens piRNA piR-56343, complete sequence.
DQ588964 - Homo sapiens piRNA piR-56076, complete sequence.
JD264221 - Sequence 245245 from Patent EP1572962.
JD266348 - Sequence 247372 from Patent EP1572962.
JD378582 - Sequence 359606 from Patent EP1572962.
JD407232 - Sequence 388256 from Patent EP1572962.
JD497531 - Sequence 478555 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: D3DPS8, ENST00000373132.1, ENST00000373132.2, ENST00000373132.3, NM_001282547, Q5VTK8, Q5VTK9, Q6ZMN1, Q8N2I9, Q8N2J8, Q8N3I6, Q96HN6, Q96I44, Q9BSA3, Q9H7H6, SGK495, SHIK, STK40_HUMAN, uc318knb.1, uc318knb.2
UCSC ID: ENST00000373132.4_14
RefSeq Accession: NM_001282547.2
Protein: Q8N2I9 (aka STK40_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.