ID:STMN1_HUMAN DESCRIPTION: RecName: Full=Stathmin; AltName: Full=Leukemia-associated phosphoprotein p18; AltName: Full=Metablastin; AltName: Full=Oncoprotein 18; Short=Op18; AltName: Full=Phosphoprotein p19; Short=pp19; AltName: Full=Prosolin; AltName: Full=Protein Pr22; AltName: Full=pp17; FUNCTION: Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser- 16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity). SUBUNIT: Binds to two alpha/beta-tubulin heterodimers. Interacts with KIST. SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. TISSUE SPECIFICITY: Ubiquitous. Expression is strongest in fetal and adult brain, spinal cord, and cerebellum, followed by thymus, bone marrow, testis, and fetal liver. Expression is intermediate in colon, ovary, placenta, uterus, and trachea, and is readily detected at substantially lower levels in all other tissues examined. Lowest expression is found in adult liver. Present in much greater abundance in cells from patients with acute leukemia of different subtypes than in normal peripheral blood lymphocytes, non-leukemic proliferating lymphoid cells, bone marrow cells, or cells from patients with chronic lymphoid or myeloid leukemia. INDUCTION: Down-regulated in response to enterovirus 71 (EV71) infection (at protein level). PTM: Many different phosphorylated forms are observed depending on specific combinations among the sites which can be phosphorylated. MAPK is responsible for the phosphorylation of stathmin in response to NGF. Phosphorylation at Ser-16 seems to be required for neuron polarization (By similarity). Phosphorylation at Ser-63 reduces tubulin binding 10-fold and suppresses the MT polymerization inhibition activity. SIMILARITY: Belongs to the stathmin family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P16949
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK303692 - Homo sapiens cDNA FLJ57769 complete cds, highly similar to Stathmin. HM005502 - Homo sapiens clone HTL-T-189 testicular tissue protein Li 189 mRNA, complete cds. BC040585 - Homo sapiens cDNA clone IMAGE:5269067, **** WARNING: chimeric clone ****. J04991 - Human p18 protein mRNA, complete cds. X53305 - H.sapiens mRNA for stathmin. Z11566 - H.sapiens mRNA for Pr22 protein. AK054594 - Homo sapiens cDNA FLJ30032 fis, clone 3NB692001366, highly similar to STATHMIN. JD131698 - Sequence 112722 from Patent EP1572962. JD122385 - Sequence 103409 from Patent EP1572962. JD452452 - Sequence 433476 from Patent EP1572962. BC023313 - Homo sapiens stathmin 1/oncoprotein 18, mRNA (cDNA clone IMAGE:4939590), with apparent retained intron. AB209282 - Homo sapiens mRNA for stathmin 1 variant protein. BX647885 - Homo sapiens mRNA; cDNA DKFZp686C18102 (from clone DKFZp686C18102). BC014353 - Homo sapiens stathmin 1/oncoprotein 18, mRNA (cDNA clone MGC:24199 IMAGE:3683516), complete cds. BC082228 - Homo sapiens stathmin 1/oncoprotein 18, mRNA (cDNA clone MGC:99593 IMAGE:2822803), complete cds. JD530755 - Sequence 511779 from Patent EP1572962. JD066408 - Sequence 47432 from Patent EP1572962. JD262483 - Sequence 243507 from Patent EP1572962. JD242297 - Sequence 223321 from Patent EP1572962. LF378810 - JP 2014500723-A/186313: Polycomb-Associated Non-Coding RNAs. JD379424 - Sequence 360448 from Patent EP1572962. JD562008 - Sequence 543032 from Patent EP1572962. AB451319 - Homo sapiens STMN1 mRNA for stathmin 1, complete cds, clone: FLJ08188AAAN. AK311801 - Homo sapiens cDNA, FLJ92062, Homo sapiens stathmin 1/oncoprotein 18 (STMN1), mRNA. CU687358 - Synthetic construct Homo sapiens gateway clone IMAGE:100023060 5' read STMN1 mRNA. KJ897121 - Synthetic construct Homo sapiens clone ccsbBroadEn_06515 STMN1 gene, encodes complete protein. KJ905819 - Synthetic construct Homo sapiens clone ccsbBroadEn_15489 STMN1 gene, encodes complete protein. AB451448 - Homo sapiens STMN1 mRNA for stathmin 1, partial cds, clone: FLJ08188AAAF. AB464250 - Synthetic construct DNA, clone: pF1KB8233, Homo sapiens STMN1 gene for stathmin 1/oncoprotein 18, without stop codon, in Flexi system. AM392854 - Synthetic construct Homo sapiens clone IMAGE:100002031 for hypothetical protein (STMN1 gene). LF378811 - JP 2014500723-A/186314: Polycomb-Associated Non-Coding RNAs. D28428 - Homo sapiens mRNA for stathmin, 5'UTR region. DQ585108 - Homo sapiens piRNA piR-52220, complete sequence. HZ409179 - JP 2015528002-A/1776: CHIRAL CONTROL. HZ460751 - WO 2015190584-A/248: Kit or device and method for detecting prostate cancer. HZ462269 - WO 2015190591-A/424: Kit and method for detecting breast cancer. HZ464481 - WO 2015194615-A/299: Kit or device and method for detecting hepatic cancer. LG052513 - KR 1020150036642-A/1779: CHIRAL CONTROL. LY498382 - KR 1020170018411-A/299: LIVER CANCER DETECTION KIT OR DEVICE, AND DETECTION METHOD. LY499272 - KR 1020170018412-A/424: BREAST CANCER DETECTION KIT OR DEVICE, AND METHOD FOR DETECTING BREAST CANCER. LY500624 - KR 1020170016490-A/248: PROSTATE CANCER DETECTION KIT OR DEVICE, AND DETECTION METHOD. LZ238643 - WO 2017171048-A/304: Kit, device and method for detecting early pancreatic cancer or precancerous lesion of pancreas. MS869543 - Sequence 248 from Patent EP3156483. MS880587 - Sequence 424 from Patent EP3156498. HW798928 - WO 2014192907-A/34: Method for detecting miRNA used for differentiating disorders causing motor neuropathy. HZ083302 - JP 2015513906-A/659: Stem Cell Microparticles. HZ437083 - JP 2015529450-A/659: Stem Cell Microparticles. HZ460565 - WO 2015190584-A/62: Kit or device and method for detecting prostate cancer. HZ461991 - WO 2015190591-A/146: Kit and method for detecting breast cancer. HZ464258 - WO 2015194615-A/76: Kit or device and method for detecting hepatic cancer. HZ480412 - JP 2015535430-A/918: TERMINALLY MODIFIED RNA. HZ790343 - JP 2016504050-A/2088: SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES. JC172287 - Sequence 659 from Patent WO2013150303. JC513075 - Sequence 3328 from Patent WO2014113089. JC573098 - Sequence 659 from Patent WO2014125276. JC582786 - Sequence 659 from Patent WO2014125277. JE954482 - Sequence 659 from Patent WO2015052526. JE956235 - Sequence 659 from Patent WO2015052527. LF137987 - JP 2016507550-A/659: Method of Producing Microparticles. LF160085 - JP 2016513950-A/151: Oligomers with improved off-target profile. LF162952 - JP 2016513095-A/659: Stem Cell Microparticles and miRNA. LF953704 - JP 2016534103-A/659: Stem Cell Microparticles and miRNA. LG006049 - KR 1020150004822-A/659: STEM CELL MICROPARTICLES. LG053745 - KR 1020150059168-A/659: STEM CELL MICROPARTICLES. LG240984 - KR 1020160035087-A/659: STEM CELL MICROPARTICLES AND MIRNA. LP896702 - Sequence 1566 from Patent EP3253886. LQ070663 - Sequence 987 from Patent EP2964234. LQ724413 - Sequence 46 from Patent WO2018096084. LV471069 - JP 2016534036-A/659: Stem Cell Microparticles and miRNA. LY498159 - KR 1020170018411-A/76: LIVER CANCER DETECTION KIT OR DEVICE, AND DETECTION METHOD. LY498994 - KR 1020170018412-A/146: BREAST CANCER DETECTION KIT OR DEVICE, AND METHOD FOR DETECTING BREAST CANCER. LY500438 - KR 1020170016490-A/62: PROSTATE CANCER DETECTION KIT OR DEVICE, AND DETECTION METHOD. LZ238392 - WO 2017171048-A/53: Kit, device and method for detecting early pancreatic cancer or precancerous lesion of pancreas. MS869357 - Sequence 62 from Patent EP3156483. MS880309 - Sequence 146 from Patent EP3156498. HZ460943 - WO 2015190584-A/440: Kit or device and method for detecting prostate cancer. HZ462556 - WO 2015190591-A/711: Kit and method for detecting breast cancer. HZ464694 - WO 2015194615-A/512: Kit or device and method for detecting hepatic cancer. LY498595 - KR 1020170018411-A/512: LIVER CANCER DETECTION KIT OR DEVICE, AND DETECTION METHOD. LY499559 - KR 1020170018412-A/711: BREAST CANCER DETECTION KIT OR DEVICE, AND METHOD FOR DETECTING BREAST CANCER. LY500816 - KR 1020170016490-A/440: PROSTATE CANCER DETECTION KIT OR DEVICE, AND DETECTION METHOD. LZ238910 - WO 2017171048-A/571: Kit, device and method for detecting early pancreatic cancer or precancerous lesion of pancreas. MS869735 - Sequence 440 from Patent EP3156483. MS880874 - Sequence 711 from Patent EP3156498. MA644164 - JP 2017113010-A/2088: SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES. MA732048 - JP 2017140048-A/918: TERMINALLY MODIFIED RNA. MA405387 - WO 2018155427-A/161: A probe with reduced false positive binding, a method to desing the probe, and the use thereof. MA614387 - JP 2018138019-A/186313: Polycomb-Associated Non-Coding RNAs. MA614388 - JP 2018138019-A/186314: Polycomb-Associated Non-Coding RNAs. MP014953 - Sequence 156 from Patent WO2019016252. MA806141 - WO 2018199275-A/401: Kit, device and method for detection of ovary tumor. MA801217 - JP 2018183181-A/2088: SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES. MA805864 - WO 2018199275-A/124: Kit, device and method for detection of ovary tumor. MA806418 - WO 2018199275-A/678: Kit, device and method for detection of ovary tumor. MA822561 - WO 2019004436-A/374: Kit, device, and method for detection of lung cancer. MA822225 - WO 2019004436-A/38: Kit, device, and method for detection of lung cancer. MP129759 - Sequence 659 from Patent EP3470073. MP162682 - Sequence 659 from Patent WO2019069093. MA822894 - WO 2019004436-A/707: Kit, device, and method for detection of lung cancer. LY616407 - KR 1020180129785-A/304: KIT OR DEVICE FOR DETECTING EARLY STAGE PANCREATIC CANCER OR PANCREATIC CANCER PRECURSOR LESIONS AND DETECTION METHOD THEREFOR. LY616156 - KR 1020180129785-A/53: KIT OR DEVICE FOR DETECTING EARLY STAGE PANCREATIC CANCER OR PANCREATIC CANCER PRECURSOR LESIONS AND DETECTION METHOD THEREFOR. LY616674 - KR 1020180129785-A/571: KIT OR DEVICE FOR DETECTING EARLY STAGE PANCREATIC CANCER OR PANCREATIC CANCER PRECURSOR LESIONS AND DETECTION METHOD THEREFOR. MB406578 - WO 2019159884-A/68: Kit, device, and method for detection of dementia. MB406974 - WO 2019159884-A/464: Kit, device, and method for detection of dementia. MB407370 - WO 2019159884-A/860: Kit, device, and method for detection of dementia. MB472898 - WO 2019208671-A/297: Kit or device and method for detecting bladder cancer. MB472662 - WO 2019208671-A/61: Kit or device and method for detecting bladder cancer. MB473150 - WO 2019208671-A/549: Kit or device and method for detecting bladder cancer.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_stathminPathway - Stathmin and breast cancer resistance to antimicrotubule agents
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
