ID:STOM_HUMAN DESCRIPTION: RecName: Full=Erythrocyte band 7 integral membrane protein; AltName: Full=Protein 7.2b; AltName: Full=Stomatin; FUNCTION: Thought to regulate cation conductance. May regulate ASIC2 and ASIC3 gating (By similarity). SUBUNIT: Homooligomer containing between 9 and 12 monomers. Interacts with ASIC1, ASIC2 and ASIC3 (By similarity). Interacts with LANCL1. SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Lipid-anchor; Cytoplasmic side. Melanosome. Note=Exposed on the cytoplasmic surface of the membrane. Associated with lipid rafts. Concentrates preferentially in plasma membrane protrusions and in a juxta-nuclear region which may represent Golgi-derived vesicles. Colocalizes with actin. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. TISSUE SPECIFICITY: Widely expressed. SIMILARITY: Belongs to the band 7/mec-2 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P27105
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005515 protein binding GO:0042802 identical protein binding GO:0042803 protein homodimerization activity GO:0070063 RNA polymerase binding
Biological Process: GO:0034765 regulation of ion transmembrane transport GO:0043312 neutrophil degranulation GO:0044829 positive regulation by host of viral genome replication GO:0048524 positive regulation of viral process GO:0051260 protein homooligomerization GO:0090314 positive regulation of protein targeting to membrane GO:1901585 regulation of acid-sensing ion channel activity
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
