Human Gene STON2 (ENST00000614646.5_9) from GENCODE V47lift37
  Description: stonin 2, transcript variant 5 (from RefSeq NM_001394390.1)
Gencode Transcript: ENST00000614646.5_9
Gencode Gene: ENSG00000140022.14_19
Transcript (Including UTRs)
   Position: hg19 chr14:81,726,996-81,866,668 Size: 139,673 Total Exon Count: 8 Strand: -
Coding Region
   Position: hg19 chr14:81,734,758-81,864,726 Size: 129,969 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr14:81,726,996-81,866,668)mRNA (may differ from genome)Protein (955 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblExonPrimerGeneCardsHGNC
MGIPubMedUniProtKB

-  Comments and Description Text from UniProtKB
  ID: H0YJ05_HUMAN
DESCRIPTION: SubName: Full=Stonin-2; Flags: Fragment;
SIMILARITY: Contains 1 MHD (mu homology) domain.
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -69.40244-0.284 Picture PostScript Text
3' UTR -2041.607762-0.263 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR008968 - Clathrin_mu_C

Pfam Domains:
PF00928 - Adaptor complexes medium subunit family
PF12016 - Stonin 2

SCOP Domains:
49447 - Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor

ModBase Predicted Comparative 3D Structure on H0YJ05
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0006897 endocytosis
GO:0036465 synaptic vesicle recycling

Cellular Component:
GO:0005623 cell
GO:0098793 presynapse


-  Descriptions from all associated GenBank mRNAs
  AB208948 - Homo sapiens mRNA for Stonin 2 variant protein.
BC117493 - Homo sapiens stonin 2, mRNA (cDNA clone MGC:151102 IMAGE:40126044), complete cds.
BC117495 - Homo sapiens stonin 2, mRNA (cDNA clone MGC:151104 IMAGE:40126046), complete cds.
AF380833 - Homo sapiens endocytosis protein HSTNB mRNA, complete cds.
BC069389 - Homo sapiens stonin 2, mRNA (cDNA clone MGC:97183 IMAGE:7262428), complete cds.
BC069359 - Homo sapiens stonin 2, mRNA (cDNA clone MGC:97172 IMAGE:7262416), complete cds.
BC069502 - Homo sapiens stonin 2, mRNA (cDNA clone MGC:97205 IMAGE:7262452), complete cds.
AF449430 - Homo sapiens endocytosis protein HSTNB variant mRNA, complete cds.
HQ258668 - Synthetic construct Homo sapiens clone IMAGE:100072698 stonin 2 (STON2) gene, encodes complete protein.
BC069587 - Homo sapiens stonin 2, mRNA (cDNA clone IMAGE:7262440), partial cds.
BX648249 - Homo sapiens mRNA; cDNA DKFZp686C02115 (from clone DKFZp686C02115).
AK094799 - Homo sapiens cDNA FLJ37480 fis, clone BRAWH2013866, highly similar to Homo sapiens stonin 2 mRNA.
JD032815 - Sequence 13839 from Patent EP1572962.
JD025867 - Sequence 6891 from Patent EP1572962.
JD364381 - Sequence 345405 from Patent EP1572962.
JD364382 - Sequence 345406 from Patent EP1572962.
JD115477 - Sequence 96501 from Patent EP1572962.
JD539265 - Sequence 520289 from Patent EP1572962.
JD342326 - Sequence 323350 from Patent EP1572962.
JD560543 - Sequence 541567 from Patent EP1572962.
AF255309 - Homo sapiens stonin 2 mRNA, complete cds.
DQ580227 - Homo sapiens piRNA piR-48339, complete sequence.
AK309171 - Homo sapiens cDNA, FLJ99212.
JD299503 - Sequence 280527 from Patent EP1572962.
JD320174 - Sequence 301198 from Patent EP1572962.
JD053574 - Sequence 34598 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000614646.1, ENST00000614646.2, ENST00000614646.3, ENST00000614646.4, H0YJ05, H0YJ05_HUMAN, NM_001394390, STON2 , uc327pjx.1, uc327pjx.2
UCSC ID: ENST00000614646.5_9
RefSeq Accession: NM_001394390.1
Protein: H0YJ05

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.