Human Gene STRIP2 (ENST00000249344.7_4) from GENCODE V47lift37
  Description: striatin interacting protein 2, transcript variant 1 (from RefSeq NM_020704.3)
Gencode Transcript: ENST00000249344.7_4
Gencode Gene: ENSG00000128578.10_8
Transcript (Including UTRs)
   Position: hg19 chr7:129,074,273-129,128,240 Size: 53,968 Total Exon Count: 21 Strand: +
Coding Region
   Position: hg19 chr7:129,074,314-129,125,670 Size: 51,357 Coding Exon Count: 21 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:129,074,273-129,128,240)mRNA (may differ from genome)Protein (834 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: FA40B_HUMAN
DESCRIPTION: RecName: Full=Protein FAM40B;
FUNCTION: Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.
SUBCELLULAR LOCATION: Cytoplasm. Note=Enriched in lamellipodia.
SIMILARITY: Belongs to the FAM40 family.
SEQUENCE CAUTION: Sequence=BAA86484.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 22.48 RPKM in Brain - Caudate (basal ganglia)
Total median expression: 143.06 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -11.8041-0.288 Picture PostScript Text
3' UTR -720.302570-0.280 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR021819 - DUF3402
IPR012486 - N1221

Pfam Domains:
PF07923 - N1221-like protein
PF11882 - Domain of unknown function (DUF3402)

ModBase Predicted Comparative 3D Structure on Q9ULQ0
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserNo ortholog
Gene DetailsGene Details  Gene Details 
Gene SorterGene Sorter  Gene Sorter 
 RGD  WormBase 
    Protein Sequence 
    Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003674 molecular_function

Biological Process:
GO:0007010 cytoskeleton organization
GO:0008360 regulation of cell shape
GO:0016477 cell migration

Cellular Component:
GO:0005737 cytoplasm
GO:0005829 cytosol


-  Descriptions from all associated GenBank mRNAs
  AK290165 - Homo sapiens cDNA FLJ76770 complete cds.
BC019064 - Homo sapiens family with sequence similarity 40, member B, mRNA (cDNA clone MGC:29781 IMAGE:4590587), complete cds.
AB032996 - Homo sapiens KIAA1170 mRNA for KIAA1170 protein.
KJ894430 - Synthetic construct Homo sapiens clone ccsbBroadEn_03824 FAM40B gene, encodes complete protein.
AB463039 - Synthetic construct DNA, clone: pF1KA1170, Homo sapiens FAM40B gene for family with sequence similarity 40, member B, without stop codon, in Flexi system.
AM392619 - Synthetic construct Homo sapiens clone IMAGE:100002673 for hypothetical protein (FAM40B gene).
AM392960 - Synthetic construct Homo sapiens clone IMAGE:100002672 for hypothetical protein (FAM40B gene).
AM392944 - Synthetic construct Homo sapiens clone IMAGE:100002913 for hypothetical protein (FAM40B gene).
AM393447 - Synthetic construct Homo sapiens clone IMAGE:100002914 for hypothetical protein (FAM40B gene).
AK302339 - Homo sapiens cDNA FLJ50746 complete cds, moderately similar to Protein FAM40B.
CU676366 - Synthetic construct Homo sapiens gateway clone IMAGE:100020064 5' read FAM40B mRNA.
DL491675 - Novel nucleic acids.
DL490260 - Novel nucleic acids.
JD516768 - Sequence 497792 from Patent EP1572962.
JD514523 - Sequence 495547 from Patent EP1572962.
JD251349 - Sequence 232373 from Patent EP1572962.
JD486052 - Sequence 467076 from Patent EP1572962.
JD222029 - Sequence 203053 from Patent EP1572962.
JD315658 - Sequence 296682 from Patent EP1572962.
JD240694 - Sequence 221718 from Patent EP1572962.
JD244121 - Sequence 225145 from Patent EP1572962.
JD046184 - Sequence 27208 from Patent EP1572962.
JD502090 - Sequence 483114 from Patent EP1572962.
JD409931 - Sequence 390955 from Patent EP1572962.
JD250483 - Sequence 231507 from Patent EP1572962.
JD514011 - Sequence 495035 from Patent EP1572962.
JD069837 - Sequence 50861 from Patent EP1572962.
JD415147 - Sequence 396171 from Patent EP1572962.
JD121015 - Sequence 102039 from Patent EP1572962.
JD339950 - Sequence 320974 from Patent EP1572962.
JD242570 - Sequence 223594 from Patent EP1572962.
JD228990 - Sequence 210014 from Patent EP1572962.
JD516469 - Sequence 497493 from Patent EP1572962.
JD099513 - Sequence 80537 from Patent EP1572962.
JD397440 - Sequence 378464 from Patent EP1572962.
JD415634 - Sequence 396658 from Patent EP1572962.
JD415635 - Sequence 396659 from Patent EP1572962.
JD252579 - Sequence 233603 from Patent EP1572962.
JD374358 - Sequence 355382 from Patent EP1572962.
JD344402 - Sequence 325426 from Patent EP1572962.
JD177664 - Sequence 158688 from Patent EP1572962.
JD473711 - Sequence 454735 from Patent EP1572962.
JD364895 - Sequence 345919 from Patent EP1572962.
JD296451 - Sequence 277475 from Patent EP1572962.
JD273066 - Sequence 254090 from Patent EP1572962.
JD053415 - Sequence 34439 from Patent EP1572962.
JD061596 - Sequence 42620 from Patent EP1572962.
JD289496 - Sequence 270520 from Patent EP1572962.
JD566585 - Sequence 547609 from Patent EP1572962.
JD374623 - Sequence 355647 from Patent EP1572962.
JD564264 - Sequence 545288 from Patent EP1572962.
JD558160 - Sequence 539184 from Patent EP1572962.
JD265704 - Sequence 246728 from Patent EP1572962.
JD122818 - Sequence 103842 from Patent EP1572962.
JD175725 - Sequence 156749 from Patent EP1572962.
JD332015 - Sequence 313039 from Patent EP1572962.
JD447677 - Sequence 428701 from Patent EP1572962.
JD085108 - Sequence 66132 from Patent EP1572962.
JD249563 - Sequence 230587 from Patent EP1572962.
JD378009 - Sequence 359033 from Patent EP1572962.
JD354048 - Sequence 335072 from Patent EP1572962.
JD269656 - Sequence 250680 from Patent EP1572962.
JD185482 - Sequence 166506 from Patent EP1572962.
JD516483 - Sequence 497507 from Patent EP1572962.
JD386070 - Sequence 367094 from Patent EP1572962.
JD386071 - Sequence 367095 from Patent EP1572962.
JD435108 - Sequence 416132 from Patent EP1572962.
JD061479 - Sequence 42503 from Patent EP1572962.
JD093217 - Sequence 74241 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000249344.1, ENST00000249344.2, ENST00000249344.3, ENST00000249344.4, ENST00000249344.5, ENST00000249344.6, FAM40B, KIAA1170, NM_020704, Q8WUZ4, Q9ULQ0, STRP2_HUMAN, uc317ezi.1, uc317ezi.2
UCSC ID: ENST00000249344.7_4
RefSeq Accession: NM_020704.3
Protein: Q9ULQ0 (aka FA40B_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.