Human Gene STRN4 (ENST00000263280.11_11) from GENCODE V47lift37

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Description: striatin 4, transcript variant 1 (from RefSeq NM_013403.3)
Gencode Transcript: ENST00000263280.11_11
Gencode Gene: ENSG00000090372.15_19
Transcript (Including UTRs)
Position: hg19 chr19:47,222,768-47,249,707 Size: 26,940 Total Exon Count: 18 Strand: -
Coding Region
Position: hg19 chr19:47,223,859-47,249,687 Size: 25,829 Coding Exon Count: 17

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr19:47,222,768-47,249,707)			mRNA (may differ from genome)		Protein (753 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	UniProtKB	Wikipedia
BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: STRN4_HUMAN DESCRIPTION: RecName: Full=Striatin-4; AltName: Full=Zinedin; FUNCTION: Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein. INTERACTION: P05412:JUN; NbExp=3; IntAct=EBI-717245, EBI-852823; SUBCELLULAR LOCATION: Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity). MISCELLANEOUS: The name 'Zinedin' probably originates from the name of the famous soccer player from Marseille (Zinedine Zidane). SIMILARITY: Belongs to the WD repeat striatin family. SIMILARITY: Contains 7 WD repeats.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene C016403 2,4-dinitrotoluene C023514 2,6-dinitrotoluene C049584 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine D000082 Acetaminophen D000535 Aluminum D001241 Aspirin D001564 Benzo(a)pyrene D003024 Clozapine D004041 Dietary Fats D006220 Haloperidol D011748 Pyrogallol D011794 Quercetin D013749 Tetrachlorodibenzodioxin D014635 Valproic Acid C044887 beta-methylcholine C069837 fullerene C60 C028007 nickel monoxide C006253 pirinixic acid C089032 rimonabant

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 76.82 RPKM in Testis Total median expression: 1156.18 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-8.60	20	-0.430	Picture	PostScript	Text
3' UTR	-379.50	894	-0.424	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR020472 - G-protein_beta_WD-40_rep
IPR013258 - Striatin_N
IPR015943 - WD40/YVTN_repeat-like_dom
IPR001680 - WD40_repeat
IPR019775 - WD40_repeat_CS
IPR017986 - WD40_repeat_dom

Pfam Domains:
PF00400 - WD domain, G-beta repeat
PF08232 - Striatin family

SCOP Domains:
50952 - Soluble quinoprotein glucose dehydrogenase
50956 - Thermostable phytase (3-phytase)
50960 - TolB, C-terminal domain
63825 - YWTD domain
63829 - Calcium-dependent phosphotriesterase
69304 - Tricorn protease N-terminal domain
101898 - NHL repeat
50965 - Galactose oxidase, central domain
75011 - 3-carboxy-cis,cis-mucoante lactonizing enzyme
101908 - Putative isomerase YbhE
117289 - Nucleoporin domain
50969 - YVTN repeat-like/Quinoprotein amine dehydrogenase
50974 - Nitrous oxide reductase, N-terminal domain
50978 - WD40 repeat-like
50993 - Peptidase/esterase 'gauge' domain
69322 - Tricorn protease domain 2
50998 - Quinoprotein alcohol dehydrogenase-like
51004 - C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase
82171 - DPP6 N-terminal domain-like

ModBase Predicted Comparative 3D Structure on Q9NRL3


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0005515 protein binding GO:0005516 calmodulin binding GO:0019904 protein domain specific binding GO:0044877 macromolecular complex binding GO:0051721 protein phosphatase 2A binding GO:0070016 armadillo repeat domain binding Biological Process: GO:0008150 biological_process Cellular Component: GO:0005737 cytoplasm GO:0016020 membrane GO:0032991 macromolecular complex GO:0042995 cell projection GO:0043197 dendritic spine GO:0000159 protein phosphatase type 2A complex

Descriptions from all associated GenBank mRNAs


	JD327358 - Sequence 308382 from Patent EP1572962. BC004910 - Homo sapiens striatin, calmodulin binding protein 4, mRNA (cDNA clone IMAGE:3532918), partial cds. AK225493 - Homo sapiens mRNA for zinedin variant, clone: JTH07586. BC014278 - Homo sapiens striatin, calmodulin binding protein 4, mRNA (cDNA clone IMAGE:3830535), containing frame-shift errors. AF212940 - Homo sapiens zinedin (ZIN) mRNA, complete cds. AK055312 - Homo sapiens cDNA FLJ30750 fis, clone FEBRA2000404. AK092913 - Homo sapiens cDNA FLJ35594 fis, clone SPLEN2007879, highly similar to Homo sapiens zinedin (ZIN) mRNA. AK056294 - Homo sapiens cDNA FLJ31732 fis, clone NT2RI2006856, highly similar to Striatin-4. BC034604 - Homo sapiens striatin, calmodulin binding protein 4, mRNA (cDNA clone MGC:41839 IMAGE:4829172), complete cds. JD079234 - Sequence 60258 from Patent EP1572962. JD089083 - Sequence 70107 from Patent EP1572962. JD187187 - Sequence 168211 from Patent EP1572962. JD416091 - Sequence 397115 from Patent EP1572962. JD200243 - Sequence 181267 from Patent EP1572962. JD543737 - Sequence 524761 from Patent EP1572962. JD231277 - Sequence 212301 from Patent EP1572962. JD162548 - Sequence 143572 from Patent EP1572962. JD204407 - Sequence 185431 from Patent EP1572962. JD252273 - Sequence 233297 from Patent EP1572962. JD374615 - Sequence 355639 from Patent EP1572962. JD222000 - Sequence 203024 from Patent EP1572962. AK297637 - Homo sapiens cDNA FLJ59351 complete cds, highly similar to Striatin-4. JD166784 - Sequence 147808 from Patent EP1572962. JD140482 - Sequence 121506 from Patent EP1572962. JD317511 - Sequence 298535 from Patent EP1572962. JD477088 - Sequence 458112 from Patent EP1572962. JD554695 - Sequence 535719 from Patent EP1572962. JD195335 - Sequence 176359 from Patent EP1572962. JD422976 - Sequence 404000 from Patent EP1572962. JD200483 - Sequence 181507 from Patent EP1572962. JD229515 - Sequence 210539 from Patent EP1572962. JD090395 - Sequence 71419 from Patent EP1572962. AB209003 - Homo sapiens mRNA for Zinedin variant protein. AB527410 - Synthetic construct DNA, clone: pF1KB3518, Homo sapiens STRN4 gene for striatin, calmodulin binding protein 4, without stop codon, in Flexi system. AK308813 - Homo sapiens cDNA, FLJ98854. AK298804 - Homo sapiens cDNA FLJ59384 complete cds, highly similar to Striatin-4. DQ596903 - Homo sapiens piRNA piR-34969, complete sequence.

Other Names for This Gene


	Alternate Gene Symbols: A0A024R0V2, B4DQH7, ENST00000263280.1, ENST00000263280.10, ENST00000263280.2, ENST00000263280.3, ENST00000263280.4, ENST00000263280.5, ENST00000263280.6, ENST00000263280.7, ENST00000263280.8, ENST00000263280.9, F8VYA6, NM_013403, Q8NE53, Q9NRL3, STRN4_HUMAN, uc317hij.1, uc317hij.2, ZIN UCSC ID: ENST00000263280.11_11 RefSeq Accession: NM_013403.3 Protein: Q9NRL3 (aka STRN4_HUMAN or ZIN_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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