ID:STXB4_HUMAN DESCRIPTION: RecName: Full=Syntaxin-binding protein 4; AltName: Full=Syntaxin 4-interacting protein; Short=STX4-interacting protein; Short=Synip; FUNCTION: Plays a role in the translocation of transport vesicles from the cytoplasm to the plasma membrane. Inhibits the translocation of SLC2A4 from intracellular vesicles to the plasma membrane by STX4A binding and preventing the interaction between STX4A and VAMP2. Stimulation with insulin disrupts the interaction with STX4A, leading to increased levels of SLC2A4 at the plasma membrane. May also play a role in the regulation of insulin release by pancreatic beta cells after stimulation by glucose (By similarity). SUBUNIT: Interacts with STX4A (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). PTM: Phosphorylated on Ser-99 by PKB/AKT2 after insulin treatment. Phosphorylation on Ser-99 abolishes the interaction with STX4A (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Contains 1 PDZ (DHR) domain. SIMILARITY: Contains 1 WW domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q6ZWJ1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006605 protein targeting GO:0006974 cellular response to DNA damage stimulus GO:0008286 insulin receptor signaling pathway GO:0010827 regulation of glucose transport GO:0010838 positive regulation of keratinocyte proliferation GO:0050821 protein stabilization GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus GO:0071346 cellular response to interferon-gamma GO:1902808 positive regulation of cell cycle G1/S phase transition
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
