ID:STYK1_HUMAN DESCRIPTION: RecName: Full=Tyrosine-protein kinase STYK1; EC=2.7.10.2; AltName: Full=Novel oncogene with kinase domain; AltName: Full=Protein PK-unique; AltName: Full=Serine/threonine/tyrosine kinase 1; FUNCTION: Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines. When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by activating both MAP kinase and phosphatidylinositol 3'-kinases (PI3K) pathways (By similarity). CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein (Potential). TISSUE SPECIFICITY: Widely expressed. Highly expressed in brain, placenta and prostate. Expressed in tumor cells such as hepatoma cells L-02, cervix carcinoma cells HeLa, ovary cancer cells Ho8910 and chronic myelogenous leukemia cells K-562, but not in other tumor cells such as epidermoid carcinoma (A-431). Undetectable in most normal lung tissues, widely expressed in lung cancers. SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein kinase family. SIMILARITY: Contains 1 protein kinase domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00069 - Protein kinase domain PF07714 - Protein tyrosine and serine/threonine kinase
SCOP Domains: 56112 - Protein kinase-like (PK-like)
ModBase Predicted Comparative 3D Structure on Q6J9G0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Cellular Component: GO:0005886 plasma membrane GO:0016020 membrane GO:0016021 integral component of membrane GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
Descriptions from all associated GenBank mRNAs
AL353940 - Homo sapiens mRNA; cDNA DKFZp761P1010 (from clone DKFZp761P1010). JD080657 - Sequence 61681 from Patent EP1572962. JD509156 - Sequence 490180 from Patent EP1572962. AF251059 - Homo sapiens kinase domain protein mRNA, complete cds. JD095950 - Sequence 76974 from Patent EP1572962. JD130947 - Sequence 111971 from Patent EP1572962. JD192208 - Sequence 173232 from Patent EP1572962. JD237140 - Sequence 218164 from Patent EP1572962. JD061029 - Sequence 42053 from Patent EP1572962. JD207330 - Sequence 188354 from Patent EP1572962. JD314989 - Sequence 296013 from Patent EP1572962. JD258895 - Sequence 239919 from Patent EP1572962. BC093822 - Homo sapiens serine/threonine/tyrosine kinase 1, mRNA (cDNA clone MGC:120857 IMAGE:7939667), complete cds. BC093824 - Homo sapiens serine/threonine/tyrosine kinase 1, mRNA (cDNA clone MGC:120859 IMAGE:7939669), complete cds. AY563054 - Homo sapiens tyrosine kinase protein mRNA, complete cds. KP729000 - Homo sapiens NOK mRNA, complete cds. AK313906 - Homo sapiens cDNA, FLJ94543. AB463252 - Synthetic construct DNA, clone: pF1KB8676, Homo sapiens STYK1 gene for serine/threonine/tyrosine kinase 1, without stop codon, in Flexi system. AM393808 - Synthetic construct Homo sapiens clone IMAGE:100001903 for hypothetical protein (STYK1 gene). JD358407 - Sequence 339431 from Patent EP1572962. JD463469 - Sequence 444493 from Patent EP1572962. JD350845 - Sequence 331869 from Patent EP1572962.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
