Human Gene SUCLG2 (ENST00000307227.10_8) from GENCODE V47lift37
  Description: succinate-CoA ligase GDP-forming subunit beta, transcript variant 2 (from RefSeq NM_003848.4)
Gencode Transcript: ENST00000307227.10_8
Gencode Gene: ENSG00000172340.15_9
Transcript (Including UTRs)
   Position: hg19 chr3:67,425,143-67,705,036 Size: 279,894 Total Exon Count: 11 Strand: -
Coding Region
   Position: hg19 chr3:67,426,168-67,705,010 Size: 278,843 Coding Exon Count: 11 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:67,425,143-67,705,036)mRNA (may differ from genome)Protein (432 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: SUCB2_HUMAN
DESCRIPTION: RecName: Full=Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial; EC=6.2.1.4; AltName: Full=GTP-specific succinyl-CoA synthetase subunit beta; AltName: Full=Succinyl-CoA synthetase beta-G chain; Short=SCS-betaG; Flags: Precursor;
FUNCTION: Catalyzes the GTP-dependent ligation of succinate and CoA to form succinyl-CoA (By similarity).
CATALYTIC ACTIVITY: GTP + succinate + CoA = GDP + phosphate + succinyl-CoA.
PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle.
SUBUNIT: Heterodimer of an alpha and a beta subunit.
SUBCELLULAR LOCATION: Mitochondrion.
TISSUE SPECIFICITY: Mainly expressed in liver, kidney, heart, spleen and skeletal muscle. Also found in intestine and colon, and in low amounts in lung, brain, prostate, testis and ovary.
SIMILARITY: Belongs to the succinate/malate CoA ligase beta subunit family.
SIMILARITY: Contains 1 ATP-grasp domain.
SEQUENCE CAUTION: Sequence=AAH07716.3; Type=Erroneous initiation; Sequence=AAH47024.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=AAH47024.1; Type=Erroneous termination; Positions=31; Note=Translated as Gln;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: SUCLG2
Diseases sorted by gene-association score: pyomyositis (9), subacute bacterial endocarditis (7), epiglottitis (7), cellulitis (5)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 52.92 RPKM in Liver
Total median expression: 873.05 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR 0.00260.000 Picture PostScript Text
3' UTR -234.501025-0.229 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR013650 - ATP-grasp_succ-CoA_synth-type
IPR013815 - ATP_grasp_subdomain_1
IPR013816 - ATP_grasp_subdomain_2
IPR005811 - CoA_ligase
IPR017866 - Succ-CoA_synthase_bsu_CS
IPR005809 - Succ_CoA_synthase_bsu
IPR016102 - Succinyl-CoA_synth-like

Pfam Domains:
PF00549 - CoA-ligase
PF08442 - ATP-grasp domain
PF13549 - ATP-grasp domain

SCOP Domains:
52210 - Succinyl-CoA synthetase domains
53822 - Periplasmic binding protein-like I
56059 - Glutathione synthetase ATP-binding domain-like

ModBase Predicted Comparative 3D Structure on Q96I99
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserNo ortholog
Gene DetailsGene Details Gene DetailsGene Details 
Gene SorterGene Sorter Gene SorterGene Sorter 
 RGDEnsembl WormBase 
    Protein Sequence 
    Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0003824 catalytic activity
GO:0004776 succinate-CoA ligase (GDP-forming) activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0005525 GTP binding
GO:0016874 ligase activity
GO:0019003 GDP binding
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity

Biological Process:
GO:0006099 tricarboxylic acid cycle
GO:0006104 succinyl-CoA metabolic process
GO:0006105 succinate metabolic process
GO:0008152 metabolic process

Cellular Component:
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005886 plasma membrane
GO:0032991 macromolecular complex
GO:0045244 succinate-CoA ligase complex (GDP-forming)


-  Descriptions from all associated GenBank mRNAs
  AK310527 - Homo sapiens cDNA, FLJ17569.
LF207309 - JP 2014500723-A/14812: Polycomb-Associated Non-Coding RNAs.
AF131748 - Homo sapiens clone 25191 GTP-specific succinyl-CoA synthetase beta subunit (SCS) mRNA sequence, partial cds.
BC019868 - Homo sapiens, clone IMAGE:4996134, mRNA, partial cds.
AL050226 - Homo sapiens mRNA; cDNA DKFZp586M2023 (from clone DKFZp586M2023).
BC035149 - Homo sapiens succinate-CoA ligase, GDP-forming, beta subunit, mRNA (cDNA clone IMAGE:5264837), partial cds.
BC047024 - Homo sapiens succinate-CoA ligase, GDP-forming, beta subunit, mRNA (cDNA clone MGC:52082 IMAGE:5415743), complete cds.
BC068602 - Homo sapiens succinate-CoA ligase, GDP-forming, beta subunit, mRNA (cDNA clone MGC:87665 IMAGE:5274341), complete cds.
BC007716 - Homo sapiens succinate-CoA ligase, GDP-forming, beta subunit, mRNA (cDNA clone MGC:12896 IMAGE:4303307), complete cds.
AF058954 - Homo sapiens GTP-specific succinyl-CoA synthetase beta subunit (SCS) mRNA, partial cds.
KJ901911 - Synthetic construct Homo sapiens clone ccsbBroadEn_11305 SUCLG2 gene, encodes complete protein.
AK294598 - Homo sapiens cDNA FLJ50080 complete cds, highly similar to Succinyl-CoA ligase (GDP-forming) beta-chain, mitochondrial precursor (EC 6.2.1.4).
CU692358 - Synthetic construct Homo sapiens gateway clone IMAGE:100021357 5' read SUCLG2 mRNA.
MA442886 - JP 2018138019-A/14812: Polycomb-Associated Non-Coding RNAs.
JD418553 - Sequence 399577 from Patent EP1572962.
JD268379 - Sequence 249403 from Patent EP1572962.
JD268380 - Sequence 249404 from Patent EP1572962.
JD237110 - Sequence 218134 from Patent EP1572962.
JD045612 - Sequence 26636 from Patent EP1572962.
LF364476 - JP 2014500723-A/171979: Polycomb-Associated Non-Coding RNAs.
JD092762 - Sequence 73786 from Patent EP1572962.
JD089657 - Sequence 70681 from Patent EP1572962.
JD085311 - Sequence 66335 from Patent EP1572962.
MA600053 - JP 2018138019-A/171979: Polycomb-Associated Non-Coding RNAs.
LF364512 - JP 2014500723-A/172015: Polycomb-Associated Non-Coding RNAs.
LF364521 - JP 2014500723-A/172024: Polycomb-Associated Non-Coding RNAs.
LF364522 - JP 2014500723-A/172025: Polycomb-Associated Non-Coding RNAs.
LF364525 - JP 2014500723-A/172028: Polycomb-Associated Non-Coding RNAs.
MA600089 - JP 2018138019-A/172015: Polycomb-Associated Non-Coding RNAs.
MA600098 - JP 2018138019-A/172024: Polycomb-Associated Non-Coding RNAs.
MA600099 - JP 2018138019-A/172025: Polycomb-Associated Non-Coding RNAs.
MA600102 - JP 2018138019-A/172028: Polycomb-Associated Non-Coding RNAs.
LF364551 - JP 2014500723-A/172054: Polycomb-Associated Non-Coding RNAs.
LF364552 - JP 2014500723-A/172055: Polycomb-Associated Non-Coding RNAs.
JD322541 - Sequence 303565 from Patent EP1572962.
JD529611 - Sequence 510635 from Patent EP1572962.
JD154852 - Sequence 135876 from Patent EP1572962.
MA600128 - JP 2018138019-A/172054: Polycomb-Associated Non-Coding RNAs.
MA600129 - JP 2018138019-A/172055: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  BioCyc Knowledge Library
PWY66-398 - TCA cycle
PWY66-407 - superpathway of conversion of glucose to acetyl CoA and entry into the TCA cycle

Reactome (by CSHL, EBI, and GO)

Protein Q96I99 (Reactome details) participates in the following event(s):

R-HSA-71775 GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA
R-HSA-71403 Citric acid cycle (TCA cycle)
R-HSA-71406 Pyruvate metabolism and Citric Acid (TCA) cycle
R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport
R-HSA-1430728 Metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: C9JVT2, ENST00000307227.1, ENST00000307227.2, ENST00000307227.3, ENST00000307227.4, ENST00000307227.5, ENST00000307227.6, ENST00000307227.7, ENST00000307227.8, ENST00000307227.9, NM_003848, O95195, Q6NUH7, Q86VX8, Q8WUQ1, Q96I99, SUCB2_HUMAN, SUCLG2 , uc317oaf.1, uc317oaf.2
UCSC ID: ENST00000307227.10_8
RefSeq Accession: NM_003848.4
Protein: Q96I99 (aka SUCB2_HUMAN or SCB2_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.