Human Gene SUCLG2 (ENST00000307227.10_8) from GENCODE V47lift37
Description: succinate-CoA ligase GDP-forming subunit beta, transcript variant 2 (from RefSeq NM_003848.4)
Gencode Transcript: ENST00000307227.10_8
Gencode Gene: ENSG00000172340.15_9
Transcript (Including UTRs)
Position: hg19 chr3:67,425,143-67,705,036 Size: 279,894 Total Exon Count: 11 Strand: -
Coding Region
Position: hg19 chr3:67,426,168-67,705,010 Size: 278,843 Coding Exon Count: 11
Data last updated at UCSC: 2024-08-22 23:36:26
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: SUCB2_HUMAN
DESCRIPTION: RecName: Full=Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial; EC=6.2.1.4; AltName: Full=GTP-specific succinyl-CoA synthetase subunit beta; AltName: Full=Succinyl-CoA synthetase beta-G chain; Short=SCS-betaG; Flags: Precursor;
FUNCTION: Catalyzes the GTP-dependent ligation of succinate and CoA to form succinyl-CoA (By similarity).CATALYTIC ACTIVITY: GTP + succinate + CoA = GDP + phosphate + succinyl-CoA.PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle.SUBUNIT: Heterodimer of an alpha and a beta subunit.SUBCELLULAR LOCATION: Mitochondrion.TISSUE SPECIFICITY: Mainly expressed in liver, kidney, heart, spleen and skeletal muscle. Also found in intestine and colon, and in low amounts in lung, brain, prostate, testis and ovary.SIMILARITY: Belongs to the succinate/malate CoA ligase beta subunit family.SIMILARITY: Contains 1 ATP-grasp domain.SEQUENCE CAUTION: Sequence=AAH07716.3; Type=Erroneous initiation; Sequence=AAH47024.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=AAH47024.1; Type=Erroneous termination; Positions=31; Note=Translated as Gln;
Primer design for this transcript
MalaCards Disease Associations
Comparative Toxicogenomics Database (CTD)
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR013650 - ATP-grasp_succ-CoA_synth-type
IPR013815 - ATP_grasp_subdomain_1
IPR013816 - ATP_grasp_subdomain_2
IPR005811 - CoA_ligase
IPR017866 - Succ-CoA_synthase_bsu_CS
IPR005809 - Succ_CoA_synthase_bsu
IPR016102 - Succinyl-CoA_synth-like
Pfam Domains: PF00549 - CoA-ligase
PF08442 - ATP-grasp domain
PF13549 - ATP-grasp domain
SCOP Domains: 52210 - Succinyl-CoA synthetase domains
53822 - Periplasmic binding protein-like I
56059 - Glutathione synthetase ATP-binding domain-like
ModBase Predicted Comparative 3D Structure on Q96I99
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
AK310527 - Homo sapiens cDNA, FLJ17569.LF207309 - JP 2014500723-A/14812: Polycomb-Associated Non-Coding RNAs.AF131748 - Homo sapiens clone 25191 GTP-specific succinyl-CoA synthetase beta subunit (SCS) mRNA sequence, partial cds.BC019868 - Homo sapiens, clone IMAGE:4996134, mRNA, partial cds.AL050226 - Homo sapiens mRNA; cDNA DKFZp586M2023 (from clone DKFZp586M2023).BC035149 - Homo sapiens succinate-CoA ligase, GDP-forming, beta subunit, mRNA (cDNA clone IMAGE:5264837), partial cds.BC047024 - Homo sapiens succinate-CoA ligase, GDP-forming, beta subunit, mRNA (cDNA clone MGC:52082 IMAGE:5415743), complete cds.BC068602 - Homo sapiens succinate-CoA ligase, GDP-forming, beta subunit, mRNA (cDNA clone MGC:87665 IMAGE:5274341), complete cds.BC007716 - Homo sapiens succinate-CoA ligase, GDP-forming, beta subunit, mRNA (cDNA clone MGC:12896 IMAGE:4303307), complete cds.AF058954 - Homo sapiens GTP-specific succinyl-CoA synthetase beta subunit (SCS) mRNA, partial cds.KJ901911 - Synthetic construct Homo sapiens clone ccsbBroadEn_11305 SUCLG2 gene, encodes complete protein.AK294598 - Homo sapiens cDNA FLJ50080 complete cds, highly similar to Succinyl-CoA ligase (GDP-forming) beta-chain, mitochondrial precursor (EC 6.2.1.4).CU692358 - Synthetic construct Homo sapiens gateway clone IMAGE:100021357 5' read SUCLG2 mRNA.MA442886 - JP 2018138019-A/14812: Polycomb-Associated Non-Coding RNAs.JD418553 - Sequence 399577 from Patent EP1572962.JD268379 - Sequence 249403 from Patent EP1572962.JD268380 - Sequence 249404 from Patent EP1572962.JD237110 - Sequence 218134 from Patent EP1572962.JD045612 - Sequence 26636 from Patent EP1572962.LF364476 - JP 2014500723-A/171979: Polycomb-Associated Non-Coding RNAs.JD092762 - Sequence 73786 from Patent EP1572962.JD089657 - Sequence 70681 from Patent EP1572962.JD085311 - Sequence 66335 from Patent EP1572962.MA600053 - JP 2018138019-A/171979: Polycomb-Associated Non-Coding RNAs.LF364512 - JP 2014500723-A/172015: Polycomb-Associated Non-Coding RNAs.LF364521 - JP 2014500723-A/172024: Polycomb-Associated Non-Coding RNAs.LF364522 - JP 2014500723-A/172025: Polycomb-Associated Non-Coding RNAs.LF364525 - JP 2014500723-A/172028: Polycomb-Associated Non-Coding RNAs.MA600089 - JP 2018138019-A/172015: Polycomb-Associated Non-Coding RNAs.MA600098 - JP 2018138019-A/172024: Polycomb-Associated Non-Coding RNAs.MA600099 - JP 2018138019-A/172025: Polycomb-Associated Non-Coding RNAs.MA600102 - JP 2018138019-A/172028: Polycomb-Associated Non-Coding RNAs.LF364551 - JP 2014500723-A/172054: Polycomb-Associated Non-Coding RNAs.LF364552 - JP 2014500723-A/172055: Polycomb-Associated Non-Coding RNAs.JD322541 - Sequence 303565 from Patent EP1572962.JD529611 - Sequence 510635 from Patent EP1572962.JD154852 - Sequence 135876 from Patent EP1572962.MA600128 - JP 2018138019-A/172054: Polycomb-Associated Non-Coding RNAs.MA600129 - JP 2018138019-A/172055: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
BioCyc Knowledge Library PWY66-398 - TCA cycle
PWY66-407 - superpathway of conversion of glucose to acetyl CoA and entry into the TCA cycle
Reactome (by CSHL, EBI, and GO) Protein Q96I99 (Reactome details) participates in the following event(s):R-HSA-71775 GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA
R-HSA-71403 Citric acid cycle (TCA cycle)
R-HSA-71406 Pyruvate metabolism and Citric Acid (TCA) cycle
R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport
R-HSA-1430728 Metabolism
Other Names for This Gene
Alternate Gene Symbols: C9JVT2, ENST00000307227.1, ENST00000307227.2, ENST00000307227.3, ENST00000307227.4, ENST00000307227.5, ENST00000307227.6, ENST00000307227.7, ENST00000307227.8, ENST00000307227.9, NM_003848, O95195, Q6NUH7, Q86VX8, Q8WUQ1, Q96I99, SUCB2_HUMAN, SUCLG2 , uc317oaf.1, uc317oaf.2UCSC ID: ENST00000307227.10_8RefSeq Accession: NM_003848.4
Protein: Q96I99
(aka SUCB2_HUMAN or SCB2_HUMAN)
Gene Model Information
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Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.