ID:SUN2_HUMAN DESCRIPTION: RecName: Full=SUN domain-containing protein 2; AltName: Full=Protein unc-84 homolog B; AltName: Full=Rab5-interacting protein; Short=Rab5IP; AltName: Full=Sad1/unc-84 protein-like 2; FUNCTION: Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for RAB5-GDP and participate in the activation of RAB5. SUBUNIT: Component of LINC complexes composed of SUN domain- containing proteins SUN1 or SUN2 coupled to KASH domain-containing proteins (SYNE1, SYNE2 or SYNE3), also called nesprins. Interacts with EMD, LMNA, RAB5A, SYNE1, SYNE2 and SYNE3. INTERACTION: Self; NbExp=2; IntAct=EBI-1044964, EBI-1044964; Q8NF91:SYNE1; NbExp=3; IntAct=EBI-1044964, EBI-928867; Q8NF91-1:SYNE1; NbExp=2; IntAct=EBI-1044964, EBI-6170938; Q8WXH0:SYNE2; NbExp=5; IntAct=EBI-1044964, EBI-2372294; Q8WXH0-1:SYNE2; NbExp=2; IntAct=EBI-1044964, EBI-6170976; SUBCELLULAR LOCATION: Nucleus inner membrane; Single-pass type II membrane protein. Endosome membrane; Single-pass type II membrane protein (Probable). TISSUE SPECIFICITY: Widely expressed. Highly expressed in heart, lung and muscle. Weakly expressed in fetal heart. Slightly overexpressed in some heart tissues form patients with congenital heart defects. DOMAIN: The SUN domain may play a role in the nuclear anchoring and/or migration. SIMILARITY: Contains 1 SUN domain. CAUTION: It is uncertain whether Met-1 or Met-50 is the initiator. SEQUENCE CAUTION: Sequence=BAA31643.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UH99
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
