Human Gene SVOPL (ENST00000674285.1_5) from GENCODE V47lift37
  Description: SVOP like, transcript variant 1 (from RefSeq NM_001139456.2)
Gencode Transcript: ENST00000674285.1_5
Gencode Gene: ENSG00000157703.16_9
Transcript (Including UTRs)
   Position: hg19 chr7:138,279,030-138,386,107 Size: 107,078 Total Exon Count: 16 Strand: -
Coding Region
   Position: hg19 chr7:138,279,355-138,363,790 Size: 84,436 Coding Exon Count: 15 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:138,279,030-138,386,107)mRNA (may differ from genome)Protein (492 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: SVOPL_HUMAN
DESCRIPTION: RecName: Full=Putative transporter SVOPL; AltName: Full=SV2-related protein-like; AltName: Full=SVOP-like protein;
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).
SIMILARITY: Belongs to the major facilitator superfamily.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -59.40219-0.271 Picture PostScript Text
3' UTR -56.70325-0.174 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011701 - MFS
IPR020846 - MFS_dom
IPR016196 - MFS_dom_general_subst_transpt
IPR005828 - Sub_transporter

Pfam Domains:
PF00083 - Sugar (and other) transporter
PF07690 - Major Facilitator Superfamily

SCOP Domains:
103473 - MFS general substrate transporter

ModBase Predicted Comparative 3D Structure on Q8N434
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0022857 transmembrane transporter activity

Biological Process:
GO:0055085 transmembrane transport

Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  BX648789 - Homo sapiens mRNA; cDNA DKFZp686B0529 (from clone DKFZp686B0529).
BC036796 - Homo sapiens SVOP-like, mRNA (cDNA clone MGC:46715 IMAGE:5590416), complete cds.
KJ900172 - Synthetic construct Homo sapiens clone ccsbBroadEn_09566 SVOPL gene, encodes complete protein.
CU691420 - Synthetic construct Homo sapiens gateway clone IMAGE:100016738 5' read SVOPL mRNA.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_001139456, Q8N434, SVOPL_HUMAN, uc329ybu.1, uc329ybu.2
UCSC ID: ENST00000674285.1_5
RefSeq Accession: NM_001139456.2
Protein: Q8N434 (aka SVOPL_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.