ID:SYT2_HUMAN DESCRIPTION: RecName: Full=Synaptotagmin-2; AltName: Full=Synaptotagmin II; Short=SytII; FUNCTION: May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone (By similarity). COFACTOR: Binds 3 calcium ions per subunit. The ions are bound to the C2 domains (By similarity). SUBUNIT: Homotetramer (Probable). Interacts with stonin 2 (By similarity). Interacts with SCAMP5. SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein (By similarity). Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane; Single-pass membrane protein (By similarity). Note=Synaptic vesicles and chromaffin granules (By similarity). DOMAIN: The first C2 domain mediates Ca(2+)-dependent phospholipid binding (By similarity). DOMAIN: The second C2 domain mediates interaction with Stonin 2 (By similarity). SIMILARITY: Belongs to the synaptotagmin family. SIMILARITY: Contains 2 C2 domains.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8N9I0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK090672 - Homo sapiens cDNA FLJ33353 fis, clone BRACE2005118, highly similar to SYNAPTOTAGMIN II. BC100814 - Homo sapiens synaptotagmin II, mRNA (cDNA clone MGC:118846 IMAGE:40000996), complete cds. BC100815 - Homo sapiens synaptotagmin II, mRNA (cDNA clone MGC:118847 IMAGE:40000997), complete cds. BC100816 - Homo sapiens synaptotagmin II, mRNA (cDNA clone IMAGE:40000998), partial cds. BC100817 - Homo sapiens synaptotagmin II, mRNA (cDNA clone MGC:118849 IMAGE:40001000), complete cds. AF070580 - Homo sapiens clone 24527 mRNA sequence. AK124510 - Homo sapiens cDNA FLJ42519 fis, clone BRACE3000787. JD326166 - Sequence 307190 from Patent EP1572962. JD354615 - Sequence 335639 from Patent EP1572962. JD364848 - Sequence 345872 from Patent EP1572962. JD492524 - Sequence 473548 from Patent EP1572962. JD426216 - Sequence 407240 from Patent EP1572962. JD371643 - Sequence 352667 from Patent EP1572962. JD132334 - Sequence 113358 from Patent EP1572962. JD231273 - Sequence 212297 from Patent EP1572962. JD566282 - Sequence 547306 from Patent EP1572962. JD203491 - Sequence 184515 from Patent EP1572962. JD062931 - Sequence 43955 from Patent EP1572962. JD192614 - Sequence 173638 from Patent EP1572962. JD108201 - Sequence 89225 from Patent EP1572962. JD289065 - Sequence 270089 from Patent EP1572962. JD188272 - Sequence 169296 from Patent EP1572962. JD171459 - Sequence 152483 from Patent EP1572962. JD468529 - Sequence 449553 from Patent EP1572962. JD496157 - Sequence 477181 from Patent EP1572962. JD508045 - Sequence 489069 from Patent EP1572962. JD446638 - Sequence 427662 from Patent EP1572962. JD133919 - Sequence 114943 from Patent EP1572962. JD226544 - Sequence 207568 from Patent EP1572962. JD180133 - Sequence 161157 from Patent EP1572962. JD162169 - Sequence 143193 from Patent EP1572962. JD544614 - Sequence 525638 from Patent EP1572962. JD508539 - Sequence 489563 from Patent EP1572962. JD223369 - Sequence 204393 from Patent EP1572962. JD488428 - Sequence 469452 from Patent EP1572962. JD219823 - Sequence 200847 from Patent EP1572962. JD246486 - Sequence 227510 from Patent EP1572962. JD463422 - Sequence 444446 from Patent EP1572962. JD109277 - Sequence 90301 from Patent EP1572962. JD108661 - Sequence 89685 from Patent EP1572962. JD334091 - Sequence 315115 from Patent EP1572962. JD134675 - Sequence 115699 from Patent EP1572962. AK123444 - Homo sapiens cDNA FLJ41450 fis, clone BRSTN2008052. JD318975 - Sequence 299999 from Patent EP1572962. JD146582 - Sequence 127606 from Patent EP1572962. JD157004 - Sequence 138028 from Patent EP1572962. JD449389 - Sequence 430413 from Patent EP1572962. AK094430 - Homo sapiens cDNA FLJ37111 fis, clone BRACE2021254, highly similar to SYNAPTOTAGMIN II. JD335015 - Sequence 316039 from Patent EP1572962. JD353274 - Sequence 334298 from Patent EP1572962. JD154488 - Sequence 135512 from Patent EP1572962. JD232820 - Sequence 213844 from Patent EP1572962. JD491871 - Sequence 472895 from Patent EP1572962. JD354251 - Sequence 335275 from Patent EP1572962. JD066258 - Sequence 47282 from Patent EP1572962. JD126319 - Sequence 107343 from Patent EP1572962. JD566644 - Sequence 547668 from Patent EP1572962. JD296957 - Sequence 277981 from Patent EP1572962. JD370508 - Sequence 351532 from Patent EP1572962. KJ895438 - Synthetic construct Homo sapiens clone ccsbBroadEn_04832 SYT2 gene, encodes complete protein. AB527568 - Synthetic construct DNA, clone: pF1KB6645, Homo sapiens SYT2 gene for synaptotagmin II, without stop codon, in Flexi system. JD269421 - Sequence 250445 from Patent EP1572962. JD520489 - Sequence 501513 from Patent EP1572962. JD444013 - Sequence 425037 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q8N9I0 (Reactome details) participates in the following event(s):
R-HSA-5244397 BoNT/B HC:LC binds SYT1 or 2 and GT1b on the target cell surface R-HSA-6794348 NRXNs bind SYTs R-HSA-8863463 STON2 binds SYT proteins R-HSA-8867756 CLASP proteins and cargo are recruited to the nascent clathrin-coated pit R-HSA-8868071 Clathrin recruits PIK3C2A R-HSA-8868661 Dynamin-mediated GTP hydrolysis promotes vesicle scission R-HSA-8868648 SYNJ hydrolyze PI(4,5)P2 to PI(4)P R-HSA-8871194 RAB5 and GAPVD1 bind AP-2 R-HSA-8868658 HSPA8-mediated ATP hydrolysis promotes vesicle uncoating R-HSA-8868659 Clathrin recruits auxilins to the clathrin-coated vesicle R-HSA-8868660 Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle R-HSA-8867754 F- and N- BAR domain proteins bind the clathrin-coated pit R-HSA-8868230 SNX9 recruits components of the actin polymerizing machinery R-HSA-8868072 Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 R-HSA-8868236 BAR domain proteins recruit dynamin R-HSA-8868651 Endophilins recruit synaptojanins to the clathrin-coated pit R-HSA-5250958 Toxicity of botulinum toxin type B (BoNT/B) R-HSA-6794361 Neurexins and neuroligins R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis R-HSA-168799 Neurotoxicity of clostridium toxins R-HSA-6794362 Protein-protein interactions at synapses R-HSA-8856828 Clathrin-mediated endocytosis R-HSA-5339562 Uptake and actions of bacterial toxins R-HSA-112316 Neuronal System R-HSA-199991 Membrane Trafficking R-HSA-5663205 Infectious disease R-HSA-5653656 Vesicle-mediated transport R-HSA-1643685 Disease
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
