Human Gene TAB1 (ENST00000216160.11_4) from GENCODE V47lift37
  Description: TGF-beta activated kinase 1 (MAP3K7) binding protein 1, transcript variant alpha (from RefSeq NM_006116.3)
Gencode Transcript: ENST00000216160.11_4
Gencode Gene: ENSG00000100324.14_7
Transcript (Including UTRs)
   Position: hg19 chr22:39,795,785-39,827,887 Size: 32,103 Total Exon Count: 11 Strand: +
Coding Region
   Position: hg19 chr22:39,795,808-39,826,227 Size: 30,420 Coding Exon Count: 11 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr22:39,795,785-39,827,887)mRNA (may differ from genome)Protein (504 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedReactomeUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TAB1_HUMAN
DESCRIPTION: RecName: Full=TGF-beta-activated kinase 1 and MAP3K7-binding protein 1; AltName: Full=Mitogen-activated protein kinase kinase kinase 7-interacting protein 1; AltName: Full=TGF-beta-activated kinase 1-binding protein 1; Short=TAK1-binding protein 1;
FUNCTION: May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis.
SUBUNIT: Interacts with XIAP and BIRC7. Interacts with TRAF6 and MAP3K7; during IL-1 signaling. Identified in the TRIKA2 complex composed of MAP3K7, TAB1 and TAB2.
TISSUE SPECIFICITY: Ubiquitous.
PTM: Monoubiquitinated. Deubiquitinated by Y.enterocolitica YopP.
SIMILARITY: Contains 1 PP2C-like domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 17.12 RPKM in Brain - Cerebellum
Total median expression: 516.02 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -4.4023-0.191 Picture PostScript Text
3' UTR -708.201660-0.427 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001932 - PP2C-like
IPR015655 - Protein_Pase_2C

Pfam Domains:
PF00481 - Protein phosphatase 2C

SCOP Domains:
81606 - PP2C-like

Protein Data Bank (PDB) 3-D Structure
MuPIT help
2J4O - X-ray MuPIT 2POM - X-ray MuPIT 2POP - X-ray MuPIT 2YIY - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on Q15750
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserNo ortholog
Gene DetailsGene Details  Gene Details 
Gene SorterGene Sorter  Gene Sorter 
 RGDEnsembl WormBase 
    Protein Sequence 
    Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003824 catalytic activity
GO:0004722 protein serine/threonine phosphatase activity
GO:0005515 protein binding
GO:0008047 enzyme activator activity
GO:0019209 kinase activator activity
GO:0044877 macromolecular complex binding
GO:0048273 mitogen-activated protein kinase p38 binding

Biological Process:
GO:0000185 activation of MAPKKK activity
GO:0000187 activation of MAPK activity
GO:0001701 in utero embryonic development
GO:0002223 stimulatory C-type lectin receptor signaling pathway
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0003007 heart morphogenesis
GO:0003279 cardiac septum development
GO:0006470 protein dephosphorylation
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0007254 JNK cascade
GO:0016579 protein deubiquitination
GO:0030324 lung development
GO:0035904 aorta development
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0043406 positive regulation of MAP kinase activity
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0060976 coronary vasculature development
GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway
GO:0070498 interleukin-1-mediated signaling pathway

Cellular Component:
GO:0005829 cytosol
GO:0010008 endosome membrane
GO:0016607 nuclear speck
GO:0032991 macromolecular complex


-  Descriptions from all associated GenBank mRNAs
  AB209372 - Homo sapiens mRNA for mitogen-activated protein kinase kinase kinase 7 interacting protein 1 isoform alpha variant protein.
BC050554 - Homo sapiens mitogen-activated protein kinase kinase kinase 7 interacting protein 1, mRNA (cDNA clone MGC:57664 IMAGE:6202841), complete cds.
AK296314 - Homo sapiens cDNA FLJ57150 complete cds, highly similar to Mitogen-activated protein kinase kinase kinase 7-interacting protein 1.
BC038582 - Homo sapiens mitogen-activated protein kinase kinase kinase 7 interacting protein 1, mRNA (cDNA clone IMAGE:5240738).
AF425640 - Homo sapiens TAB1-like protein mRNA, complete cds.
AK312456 - Homo sapiens cDNA, FLJ92811, Homo sapiens mitogen-activated protein kinase kinase kinase 7interacting protein 1 (MAP3K7IP1), mRNA.
U49928 - Homo sapiens TAK1 binding protein (TAB1) mRNA, complete cds.
AK291668 - Homo sapiens cDNA FLJ78598 complete cds, highly similar to Homo sapiens mitogen-activated protein kinase kinase kinase 7 interacting protein 1 (MAP3K7IP1), transcript variant alpha, mRNA.
AK316004 - Homo sapiens cDNA, FLJ78903 complete cds, highly similar to Mitogen-activated protein kinase kinase kinase 7-interacting protein 1.
AK308903 - Homo sapiens cDNA, FLJ98944.
CU690722 - Synthetic construct Homo sapiens gateway clone IMAGE:100021438 5' read MAP3K7IP1 mRNA.
AB591024 - Synthetic construct DNA, clone: pFN21AE1949, Homo sapiens MAP3K7IP1 gene for mitogen-activated protein kinase kinase kinase 7 interacting protein 1, without stop codon, in Flexi system.
KJ893047 - Synthetic construct Homo sapiens clone ccsbBroadEn_02441 TAB1 gene, encodes complete protein.
JD020520 - Sequence 1544 from Patent EP1572962.
JD543583 - Sequence 524607 from Patent EP1572962.
JD468870 - Sequence 449894 from Patent EP1572962.
JD405973 - Sequence 386997 from Patent EP1572962.
JD064877 - Sequence 45901 from Patent EP1572962.
JD436414 - Sequence 417438 from Patent EP1572962.
JD494960 - Sequence 475984 from Patent EP1572962.
JD209960 - Sequence 190984 from Patent EP1572962.
JD493574 - Sequence 474598 from Patent EP1572962.
JD380698 - Sequence 361722 from Patent EP1572962.
JD390626 - Sequence 371650 from Patent EP1572962.
JD115605 - Sequence 96629 from Patent EP1572962.
JD374899 - Sequence 355923 from Patent EP1572962.
JD368571 - Sequence 349595 from Patent EP1572962.
JD160582 - Sequence 141606 from Patent EP1572962.
JD280993 - Sequence 262017 from Patent EP1572962.
JD194400 - Sequence 175424 from Patent EP1572962.
JD097985 - Sequence 79009 from Patent EP1572962.
JD102793 - Sequence 83817 from Patent EP1572962.
JD347282 - Sequence 328306 from Patent EP1572962.
JD166364 - Sequence 147388 from Patent EP1572962.
JD170643 - Sequence 151667 from Patent EP1572962.
JD147363 - Sequence 128387 from Patent EP1572962.
JD229948 - Sequence 210972 from Patent EP1572962.
JD373591 - Sequence 354615 from Patent EP1572962.
JD442110 - Sequence 423134 from Patent EP1572962.
JD403208 - Sequence 384232 from Patent EP1572962.
EF036484 - Homo sapiens 3'-Tab1 mRNA, partial cds.
JD363093 - Sequence 344117 from Patent EP1572962.
JD118124 - Sequence 99148 from Patent EP1572962.
JD116523 - Sequence 97547 from Patent EP1572962.
JD276868 - Sequence 257892 from Patent EP1572962.
JD217202 - Sequence 198226 from Patent EP1572962.
JD427311 - Sequence 408335 from Patent EP1572962.
JD216066 - Sequence 197090 from Patent EP1572962.
JD468348 - Sequence 449372 from Patent EP1572962.
JD456026 - Sequence 437050 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_tgfbPathway - TGF beta signaling pathway
h_tollPathway - Toll-Like Receptor Pathway
h_il1rPathway - Signal transduction through IL1R
h_nfkbPathway - NF-kB Signaling Pathway
h_wntPathway - WNT Signaling Pathway

Reactome (by CSHL, EBI, and GO)

Protein Q15750 (Reactome details) participates in the following event(s):

R-HSA-446870 Polyubiquitinated TRAF6 binds the TAK1 complex
R-HSA-936960 Activated TRAF6:p-IRAK2 interacts with TAK1 complex
R-HSA-975097 Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation
R-HSA-177690 Activated TLR3:TRIF:K63pUb-TRAF6 recruits TAK1complex
R-HSA-936947 Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex
R-HSA-2730861 Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6
R-HSA-5357860 TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3 recruits TAK1 complex
R-HSA-5607759 TRIKA2 binds K63polyUb-TRAF6 oligomer
R-HSA-847070 Phosphorylated TAK1 dissociates from the TLR3 receptor complex
R-HSA-937075 Phosphorylated TAK1 leaves activated TLR receptor complex
R-HSA-936951 Activation of TAK1 complex bound to activated TLR4 complex
R-HSA-936991 Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3
R-HSA-5696534 USP18 deubiquitinates TAK1:TAB1
R-HSA-688985 K63 polyubiquitinated RIP2 associates with the TAK1 complex
R-HSA-177692 Activation of recruited TAK1 within the activated TLR3 complex
R-HSA-975103 Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 upon TLR7/8 or 9 activation
R-HSA-727819 TAK1 phosphorylates MKK6
R-HSA-5607732 K63polyUb-TAK1 autophosphorylates
R-HSA-2730876 Phosphorylation of IKK-beta by TAK1
R-HSA-168184 Activated TAK1 mediates phosphorylation of the IKK Complex
R-HSA-450337 Activated TAK1 phosphorylates MKK4/MKK7
R-HSA-450346 activated human TAK1 phosphorylates MKK3/MKK6
R-HSA-5607742 K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta
R-HSA-9020702 Interleukin-1 signaling
R-HSA-937042 IRAK2 mediated activation of TAK1 complex
R-HSA-975163 IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
R-HSA-9014325 TICAM1,TRAF6-dependent induction of TAK1 complex
R-HSA-937072 TRAF6-mediated induction of TAK1 complex within TLR4 complex
R-HSA-2871837 FCERI mediated NF-kB activation
R-HSA-5357956 TNFR1-induced NFkappaB signaling pathway
R-HSA-5607764 CLEC7A (Dectin-1) signaling
R-HSA-5689880 Ub-specific processing proteases
R-HSA-168638 NOD1/2 Signaling Pathway
R-HSA-446652 Interleukin-1 family signaling
R-HSA-166058 MyD88:Mal cascade initiated on plasma membrane
R-HSA-975871 MyD88 cascade initiated on plasma membrane
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade
R-HSA-937061 TRIF(TICAM1)-mediated TLR4 signaling
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling
R-HSA-75893 TNF signaling
R-HSA-5621481 C-type lectin receptors (CLRs)
R-HSA-5688426 Deubiquitination
R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
R-HSA-449147 Signaling by Interleukins
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade
R-HSA-975155 MyD88 dependent cascade initiated on endosome
R-HSA-168898 Toll-Like Receptors Cascades
R-HSA-166166 MyD88-independent TLR4 cascade
R-HSA-168249 Innate Immune System
R-HSA-73887 Death Receptor Signalling
R-HSA-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-HSA-450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
R-HSA-450302 activated TAK1 mediates p38 MAPK activation
R-HSA-597592 Post-translational protein modification
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade
R-HSA-168256 Immune System
R-HSA-162582 Signal Transduction
R-HSA-450294 MAP kinase activation
R-HSA-392499 Metabolism of proteins
R-HSA-448424 Interleukin-17 signaling

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000216160.1, ENST00000216160.10, ENST00000216160.2, ENST00000216160.3, ENST00000216160.4, ENST00000216160.5, ENST00000216160.6, ENST00000216160.7, ENST00000216160.8, ENST00000216160.9, MAP3K7IP1, NM_006116, Q15750, Q2PP09, Q8IZW2, TAB1_HUMAN, uc317cow.1, uc317cow.2
UCSC ID: ENST00000216160.11_4
RefSeq Accession: NM_006116.3
Protein: Q15750 (aka TAB1_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.