Human Gene TAB3 (ENST00000288422.4_6) from GENCODE V47lift37
  Description: TGF-beta activated kinase 1 (MAP3K7) binding protein 3, transcript variant 1 (from RefSeq NM_152787.5)
Gencode Transcript: ENST00000288422.4_6
Gencode Gene: ENSG00000157625.16_13
Transcript (Including UTRs)
   Position: hg19 chrX:30,845,559-30,907,371 Size: 61,813 Total Exon Count: 11 Strand: -
Coding Region
   Position: hg19 chrX:30,849,544-30,877,705 Size: 28,162 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chrX:30,845,559-30,907,371)mRNA (may differ from genome)Protein (712 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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HGNCMGIOMIMPubMedReactomeUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TAB3_HUMAN
DESCRIPTION: RecName: Full=TGF-beta-activated kinase 1 and MAP3K7-binding protein 3; AltName: Full=Mitogen-activated protein kinase kinase kinase 7-interacting protein 3; AltName: Full=NF-kappa-B-activating protein 1; AltName: Full=TAK1-binding protein 3; Short=TAB-3; AltName: Full=TGF-beta-activated kinase 1-binding protein 3;
FUNCTION: Adapter linking MAP3K7/TAK1 and TRAF6 or TRAF2. Mediator of MAP3K7 activation, respectively in the IL1 and TNF signaling pathways. Plays a role in activation of NF-kappa-B and AP1 transcription factor. Isoform 2 may be an oncogenic factor.
SUBUNIT: Interacts with TAB1, TAB2, MAP3K7, TRAF2 and TRAF6. The minimal TAB3-containing complex (TAB1-MAP3K7-TAB3) appears not to contain TAB2. However, it seems sensible to consider that TAB2 may also join this complex and may act in a cooperative manner with TAB3. Interacts with WDR34 (via the WD domains). Interacts with RBCK1. Binds 'Lys-63'-linked polyubiquitin chains.
INTERACTION: Q62073:Map3k7 (xeno); NbExp=2; IntAct=EBI-359964, EBI-1775345;
TISSUE SPECIFICITY: Widely expressed. Constitutively overexpressed in certain tumor tissues. Isoform 1 is a major transcript while isoform 2 is a minor transcript.
DOMAIN: The RanBP2-type zinc finger (NZF) mediates binding to two consecutive 'Lys-63'-linked ubiquitins (By similarity).
PTM: Ubiquitinated; following IL1 stimulation or TRAF6 overexpression.
PTM: Phosphorylated at Ser-506 by MAPKAPK2 and MAPKAPK3 following IL1 treatment.
SIMILARITY: Contains 1 CUE domain.
SIMILARITY: Contains 1 RanBP2-type zinc finger.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 7.90 RPKM in Uterus
Total median expression: 150.34 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -186.00523-0.356 Picture PostScript Text
3' UTR -984.703985-0.247 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR003892 - CUE
IPR001876 - Znf_RanBP2

Pfam Domains:
PF00641 - Zn-finger in Ran binding protein and others
PF02845 - CUE domain

SCOP Domains:
46934 - UBA-like
90209 - Ran binding protein zinc finger-like

ModBase Predicted Comparative 3D Structure on Q8N5C8
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0046872 metal ion binding

Biological Process:
GO:0000187 activation of MAPK activity
GO:0002223 stimulatory C-type lectin receptor signaling pathway
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0007254 JNK cascade
GO:0010507 negative regulation of autophagy
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway
GO:0070498 interleukin-1-mediated signaling pathway

Cellular Component:
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0010008 endosome membrane
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  AY331591 - Homo sapiens NFkB activating protein 1 isoform A (TAB3) mRNA, complete cds, alternatively spliced.
AY331592 - Homo sapiens NFkB activating protein 1 isoform B (TAB3) mRNA, complete cds, alternatively spliced.
LF211560 - JP 2014500723-A/19063: Polycomb-Associated Non-Coding RNAs.
AK096786 - Homo sapiens cDNA FLJ39467 fis, clone PROST2012448.
AK297274 - Homo sapiens cDNA FLJ60687 complete cds, highly similar to Mitogen-activated protein kinase kinase kinase7-interacting protein 3.
LF381128 - JP 2014500723-A/188631: Polycomb-Associated Non-Coding RNAs.
LF381127 - JP 2014500723-A/188630: Polycomb-Associated Non-Coding RNAs.
LF381126 - JP 2014500723-A/188629: Polycomb-Associated Non-Coding RNAs.
BC032526 - Homo sapiens mitogen-activated protein kinase kinase kinase 7 interacting protein 3, mRNA (cDNA clone MGC:45404 IMAGE:5502039), complete cds.
JD120278 - Sequence 101302 from Patent EP1572962.
JD225091 - Sequence 206115 from Patent EP1572962.
JD295492 - Sequence 276516 from Patent EP1572962.
LF381125 - JP 2014500723-A/188628: Polycomb-Associated Non-Coding RNAs.
JD083596 - Sequence 64620 from Patent EP1572962.
JD504131 - Sequence 485155 from Patent EP1572962.
JD040733 - Sequence 21757 from Patent EP1572962.
JD502857 - Sequence 483881 from Patent EP1572962.
AY371491 - Homo sapiens TAK1 binding protein 3 (TAB3) mRNA, complete cds.
AY437560 - Homo sapiens TAK1-binding protein 3 (TAB3) mRNA, complete cds.
AL832071 - Homo sapiens mRNA; cDNA DKFZp313L0918 (from clone DKFZp313L0918).
JD053602 - Sequence 34626 from Patent EP1572962.
JD380388 - Sequence 361412 from Patent EP1572962.
LF381120 - JP 2014500723-A/188623: Polycomb-Associated Non-Coding RNAs.
LF381119 - JP 2014500723-A/188622: Polycomb-Associated Non-Coding RNAs.
LF381118 - JP 2014500723-A/188621: Polycomb-Associated Non-Coding RNAs.
MA447137 - JP 2018138019-A/19063: Polycomb-Associated Non-Coding RNAs.
MA616705 - JP 2018138019-A/188631: Polycomb-Associated Non-Coding RNAs.
MA616704 - JP 2018138019-A/188630: Polycomb-Associated Non-Coding RNAs.
MA616703 - JP 2018138019-A/188629: Polycomb-Associated Non-Coding RNAs.
MA616702 - JP 2018138019-A/188628: Polycomb-Associated Non-Coding RNAs.
MA616697 - JP 2018138019-A/188623: Polycomb-Associated Non-Coding RNAs.
MA616696 - JP 2018138019-A/188622: Polycomb-Associated Non-Coding RNAs.
MA616695 - JP 2018138019-A/188621: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q8N5C8 (Reactome details) participates in the following event(s):

R-HSA-688985 K63 polyubiquitinated RIP2 associates with the TAK1 complex
R-HSA-177692 Activation of recruited TAK1 within the activated TLR3 complex
R-HSA-177690 Activated TLR3:TRIF:K63pUb-TRAF6 recruits TAK1complex
R-HSA-847070 Phosphorylated TAK1 dissociates from the TLR3 receptor complex
R-HSA-975103 Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 upon TLR7/8 or 9 activation
R-HSA-446870 Polyubiquitinated TRAF6 binds the TAK1 complex
R-HSA-936960 Activated TRAF6:p-IRAK2 interacts with TAK1 complex
R-HSA-975097 Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation
R-HSA-936947 Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex
R-HSA-2730861 Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6
R-HSA-5357860 TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3 recruits TAK1 complex
R-HSA-5607759 TRIKA2 binds K63polyUb-TRAF6 oligomer
R-HSA-937075 Phosphorylated TAK1 leaves activated TLR receptor complex
R-HSA-936951 Activation of TAK1 complex bound to activated TLR4 complex
R-HSA-936991 Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3
R-HSA-727819 TAK1 phosphorylates MKK6
R-HSA-5607732 K63polyUb-TAK1 autophosphorylates
R-HSA-2730876 Phosphorylation of IKK-beta by TAK1
R-HSA-168184 Activated TAK1 mediates phosphorylation of the IKK Complex
R-HSA-450337 Activated TAK1 phosphorylates MKK4/MKK7
R-HSA-450346 activated human TAK1 phosphorylates MKK3/MKK6
R-HSA-5607742 K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta
R-HSA-168638 NOD1/2 Signaling Pathway
R-HSA-9014325 TICAM1,TRAF6-dependent induction of TAK1 complex
R-HSA-975163 IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
R-HSA-9020702 Interleukin-1 signaling
R-HSA-937042 IRAK2 mediated activation of TAK1 complex
R-HSA-937072 TRAF6-mediated induction of TAK1 complex within TLR4 complex
R-HSA-2871837 FCERI mediated NF-kB activation
R-HSA-5357956 TNFR1-induced NFkappaB signaling pathway
R-HSA-5607764 CLEC7A (Dectin-1) signaling
R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
R-HSA-446652 Interleukin-1 family signaling
R-HSA-166058 MyD88:Mal cascade initiated on plasma membrane
R-HSA-975871 MyD88 cascade initiated on plasma membrane
R-HSA-937061 TRIF(TICAM1)-mediated TLR4 signaling
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling
R-HSA-75893 TNF signaling
R-HSA-5621481 C-type lectin receptors (CLRs)
R-HSA-168249 Innate Immune System
R-HSA-168898 Toll-Like Receptors Cascades
R-HSA-975155 MyD88 dependent cascade initiated on endosome
R-HSA-449147 Signaling by Interleukins
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade
R-HSA-166166 MyD88-independent TLR4 cascade
R-HSA-73887 Death Receptor Signalling
R-HSA-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-HSA-450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
R-HSA-450302 activated TAK1 mediates p38 MAPK activation
R-HSA-168256 Immune System
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade
R-HSA-162582 Signal Transduction
R-HSA-450294 MAP kinase activation
R-HSA-448424 Interleukin-17 signaling

-  Other Names for This Gene
  Alternate Gene Symbols: A6NDD9, ENST00000288422.1, ENST00000288422.2, ENST00000288422.3, MAP3K7IP3, NM_152787, Q6VQR0, Q8N5C8, TAB3 , TAB3_HUMAN, uc317kps.1, uc317kps.2
UCSC ID: ENST00000288422.4_6
RefSeq Accession: NM_152787.5
Protein: Q8N5C8 (aka TAB3_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.