Human Gene TADA2B (ENST00000310074.8_4) from GENCODE V47lift37

JavaScript is disabled in your web browser

You must have JavaScript enabled in your web browser to use the Genome Browser

Description: transcriptional adaptor 2B (from RefSeq NM_152293.3)
Gencode Transcript: ENST00000310074.8_4
Gencode Gene: ENSG00000173011.12_9
Transcript (Including UTRs)
Position: hg19 chr4:7,045,099-7,059,679 Size: 14,581 Total Exon Count: 2 Strand: +
Coding Region
Position: hg19 chr4:7,045,307-7,056,781 Size: 11,475 Coding Exon Count: 2

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr4:7,045,099-7,059,679)			mRNA (may differ from genome)		Protein (420 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	Reactome	UniProtKB
BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: TAD2B_HUMAN DESCRIPTION: RecName: Full=Transcriptional adapter 2-beta; AltName: Full=ADA2-like protein beta; Short=ADA2-beta; FUNCTION: Coactivates PAX5-dependent transcription together with either SMARCA4 or GCN5L2. SUBUNIT: Interacts with GCN5L2, SMARCA4, SMARCE1 and PAX5. Component of the TFTC-HAT complex. SUBCELLULAR LOCATION: Nucleus (Probable). SIMILARITY: Contains 1 SANT domain. SIMILARITY: Contains 1 ZZ-type zinc finger. SEQUENCE CAUTION: Sequence=AAH47794.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=AAI01338.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D004958 Estradiol D005557 Formaldehyde D005839 Gentamicins C006780 bisphenol A

Common Gene Haplotype Alleles


	Press "+" in the title bar above to open this section.

RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 13.98 RPKM in Muscle - Skeletal Total median expression: 325.85 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


	Press "+" in the title bar above to open this section.

mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-133.40	208	-0.641	Picture	PostScript	Text
3' UTR	-958.20	2898	-0.331	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR009057 - Homeodomain-like
IPR001005 - SANT/Myb
IPR017884 - SANT_dom
IPR016827 - Transcriptional_adaptor_2
IPR000433 - Znf_ZZ

Pfam Domains:
PF00249 - Myb-like DNA-binding domain
PF13921 - Myb-like DNA-binding domain

SCOP Domains:
46689 - Homeodomain-like
57850 - RING/U-box

ModBase Predicted Comparative 3D Structure on Q86TJ2


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details		Gene Details
Gene Sorter	Gene Sorter		Gene Sorter
	RGD	Ensembl

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0003677 DNA binding GO:0003682 chromatin binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0003713 transcription coactivator activity GO:0008270 zinc ion binding GO:0036459 thiol-dependent ubiquitinyl hydrolase activity GO:0046872 metal ion binding GO:0004402 histone acetyltransferase activity Biological Process: GO:0006338 chromatin remodeling GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0016573 histone acetylation GO:0016579 protein deubiquitination GO:0035065 regulation of histone acetylation GO:0035066 positive regulation of histone acetylation Cellular Component: GO:0005634 nucleus GO:0005654 nucleoplasm GO:0030914 STAGA complex GO:0070461 SAGA-type complex

Descriptions from all associated GenBank mRNAs


	AK126966 - Homo sapiens cDNA FLJ45019 fis, clone BRAWH3015825. BC101334 - Homo sapiens transcriptional adaptor 2 (ADA2 homolog, yeast)-beta, mRNA (cDNA clone MGC:120461 IMAGE:40025078), complete cds. BC101335 - Homo sapiens transcriptional adaptor 2 (ADA2 homolog, yeast)-beta, mRNA (cDNA clone MGC:120462 IMAGE:40025081), complete cds. BC101336 - Homo sapiens transcriptional adaptor 2 (ADA2 homolog, yeast)-beta, mRNA (cDNA clone MGC:120463 IMAGE:40025082), complete cds. BC101337 - Homo sapiens transcriptional adaptor 2 (ADA2 homolog, yeast)-beta, mRNA (cDNA clone IMAGE:40025083), partial cds. BC047794 - Homo sapiens transcriptional adaptor 2 (ADA2 homolog, yeast)-beta, mRNA (cDNA clone IMAGE:6190777), partial cds. JD542120 - Sequence 523144 from Patent EP1572962. JD217645 - Sequence 198669 from Patent EP1572962. AK093974 - Homo sapiens cDNA FLJ36655 fis, clone UTERU2001658, weakly similar to Transcriptional adapter 2. AX748390 - Sequence 1915 from Patent EP1308459. JD485268 - Sequence 466292 from Patent EP1572962. JD214506 - Sequence 195530 from Patent EP1572962. AB590997 - Synthetic construct DNA, clone: pFN21AE1142, Homo sapiens TADA2B gene for transcriptional adaptor 2B, without stop codon, in Flexi system. AK096655 - Homo sapiens cDNA FLJ39336 fis, clone OCBBF2017815. BX641147 - Homo sapiens mRNA; cDNA DKFZp686A15231 (from clone DKFZp686A15231). KJ903605 - Synthetic construct Homo sapiens clone ccsbBroadEn_12999 TADA2B gene, encodes complete protein. BX648428 - Homo sapiens mRNA; cDNA DKFZp686C18253 (from clone DKFZp686C18253). BC013164 - Homo sapiens transcriptional adaptor 2 (ADA2 homolog, yeast)-beta, mRNA (cDNA clone IMAGE:4342667), partial cds. AK026299 - Homo sapiens cDNA: FLJ22646 fis, clone HSI07178. JD155001 - Sequence 136025 from Patent EP1572962. JD486329 - Sequence 467353 from Patent EP1572962. JD126257 - Sequence 107281 from Patent EP1572962. JD177271 - Sequence 158295 from Patent EP1572962. JD255349 - Sequence 236373 from Patent EP1572962. BC078156 - Homo sapiens cDNA clone IMAGE:6050873, partial cds. JD334356 - Sequence 315380 from Patent EP1572962. BC064337 - Homo sapiens transcriptional adaptor 2 (ADA2 homolog, yeast)-beta, mRNA (cDNA clone IMAGE:4344077), partial cds. JD123717 - Sequence 104741 from Patent EP1572962. JD483295 - Sequence 464319 from Patent EP1572962. JD325149 - Sequence 306173 from Patent EP1572962. JD449123 - Sequence 430147 from Patent EP1572962. JD302766 - Sequence 283790 from Patent EP1572962. JD304807 - Sequence 285831 from Patent EP1572962. JD047262 - Sequence 28286 from Patent EP1572962. JD287353 - Sequence 268377 from Patent EP1572962. JD462431 - Sequence 443455 from Patent EP1572962. JD142039 - Sequence 123063 from Patent EP1572962. JD486446 - Sequence 467470 from Patent EP1572962. JD443563 - Sequence 424587 from Patent EP1572962. JD318803 - Sequence 299827 from Patent EP1572962. JD392074 - Sequence 373098 from Patent EP1572962. JD358511 - Sequence 339535 from Patent EP1572962. JD117717 - Sequence 98741 from Patent EP1572962. JD223378 - Sequence 204402 from Patent EP1572962. JD192582 - Sequence 173606 from Patent EP1572962. JD134163 - Sequence 115187 from Patent EP1572962. JD421156 - Sequence 402180 from Patent EP1572962. JD418927 - Sequence 399951 from Patent EP1572962. JD305496 - Sequence 286520 from Patent EP1572962. JD259662 - Sequence 240686 from Patent EP1572962. DQ589357 - Homo sapiens piRNA piR-56469, complete sequence. JD042070 - Sequence 23094 from Patent EP1572962. JD515469 - Sequence 496493 from Patent EP1572962. JD361819 - Sequence 342843 from Patent EP1572962. JD205966 - Sequence 186990 from Patent EP1572962. JD239406 - Sequence 220430 from Patent EP1572962. JD503925 - Sequence 484949 from Patent EP1572962. JD061188 - Sequence 42212 from Patent EP1572962. DQ592602 - Homo sapiens piRNA piR-59714, complete sequence.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein Q86TJ2 (Reactome details) participates in the following event(s): R-HSA-3301237 KAT2 complexes acetylate histone H3 R-HSA-5690080 USP3,SAGA deubiquitinate Histone H2A,H2B R-HSA-3214847 HATs acetylate histones R-HSA-5689880 Ub-specific processing proteases R-HSA-3247509 Chromatin modifying enzymes R-HSA-5688426 Deubiquitination R-HSA-4839726 Chromatin organization R-HSA-597592 Post-translational protein modification R-HSA-392499 Metabolism of proteins

Other Names for This Gene


	Alternate Gene Symbols: A0AUJ8, A4QMR7, ADA2B, B3KSN0, B3KU86, ENST00000310074.1, ENST00000310074.2, ENST00000310074.3, ENST00000310074.4, ENST00000310074.5, ENST00000310074.6, ENST00000310074.7, NM_152293, Q6MZG9, Q86TJ2, TAD2B_HUMAN, uc317orh.1, uc317orh.2 UCSC ID: ENST00000310074.8_4 RefSeq Accession: NM_152293.3 Protein: Q86TJ2 (aka TAD2B_HUMAN)

Gene Model Information


	Click here for a detailed description of the fields of the table above.

Methods, Credits, and Use Restrictions


	Click here for details on how this gene model was made and data restrictions if any.