ID:TAF11_HUMAN DESCRIPTION: RecName: Full=Transcription initiation factor TFIID subunit 11; AltName: Full=TFIID subunit p30-beta; AltName: Full=Transcription initiation factor TFIID 28 kDa subunit; Short=TAF(II)28; Short=TAFII-28; Short=TAFII28; FUNCTION: Core TAFII present in both of the previously described TFIID species which either lack or contain TAFII30 (TFIID alpha and TFIID beta respectively). SUBUNIT: TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). Interacts with TAF13 both in vitro and intracellularly; also interacts directly with TBP. INTERACTION: Q15543:TAF13; NbExp=2; IntAct=EBI-1027005, EBI-1026992; SUBCELLULAR LOCATION: Nucleus. DOMAIN: TBP and TAFII18 bind to distinct domains of TAFII28. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Belongs to the TAF11 family. SEQUENCE CAUTION: Sequence=AAF22038.1; Type=Frameshift; Positions=208; WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/taf11/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q15544
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0003713 transcription coactivator activity GO:0005515 protein binding GO:0042809 vitamin D receptor binding GO:0046966 thyroid hormone receptor binding GO:0046982 protein heterodimerization activity GO:0047485 protein N-terminus binding
Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006366 transcription from RNA polymerase II promoter GO:0006367 transcription initiation from RNA polymerase II promoter GO:0042795 snRNA transcription from RNA polymerase II promoter GO:0043923 positive regulation by host of viral transcription GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly GO:1901796 regulation of signal transduction by p53 class mediator
LF210764 - JP 2014500723-A/18267: Polycomb-Associated Non-Coding RNAs. BX538195 - Homo sapiens mRNA; cDNA DKFZp686H04208 (from clone DKFZp686H04208). BX647568 - Homo sapiens mRNA; cDNA DKFZp313C0811 (from clone DKFZp313C0811). AF118094 - Homo sapiens PRO2134 mRNA, complete cds. BC021972 - Homo sapiens TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa, mRNA (cDNA clone MGC:15243 IMAGE:3935882), complete cds. JD279911 - Sequence 260935 from Patent EP1572962. JD313943 - Sequence 294967 from Patent EP1572962. JD530437 - Sequence 511461 from Patent EP1572962. JD166332 - Sequence 147356 from Patent EP1572962. AK302226 - Homo sapiens cDNA FLJ50289 complete cds, highly similar to Transcription initiation factor TFIID subunit 11. JD159963 - Sequence 140987 from Patent EP1572962. JD213580 - Sequence 194604 from Patent EP1572962. JD227923 - Sequence 208947 from Patent EP1572962. JD342089 - Sequence 323113 from Patent EP1572962. JD293456 - Sequence 274480 from Patent EP1572962. JD051471 - Sequence 32495 from Patent EP1572962. JD426030 - Sequence 407054 from Patent EP1572962. JD480843 - Sequence 461867 from Patent EP1572962. JD308310 - Sequence 289334 from Patent EP1572962. JD435525 - Sequence 416549 from Patent EP1572962. JD377450 - Sequence 358474 from Patent EP1572962. JD454907 - Sequence 435931 from Patent EP1572962. JD187444 - Sequence 168468 from Patent EP1572962. JD146238 - Sequence 127262 from Patent EP1572962. JD146796 - Sequence 127820 from Patent EP1572962. JD417977 - Sequence 399001 from Patent EP1572962. JD465131 - Sequence 446155 from Patent EP1572962. JD271860 - Sequence 252884 from Patent EP1572962. JD531399 - Sequence 512423 from Patent EP1572962. JD501638 - Sequence 482662 from Patent EP1572962. X83928 - H.sapiens mRNA for transcription factor TFIID subunit TAFII28. JD524279 - Sequence 505303 from Patent EP1572962. D63705 - Homo sapiens mRNA for TFIID subunit p30beta, complete cds. JD286206 - Sequence 267230 from Patent EP1572962. BT019404 - Homo sapiens TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa mRNA, complete cds. BT019405 - Homo sapiens TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa mRNA, complete cds. DQ893239 - Synthetic construct clone IMAGE:100005869; FLH195516.01X; RZPDo839D04152D TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa (TAF11) gene, encodes complete protein. AK313475 - Homo sapiens cDNA, FLJ94022, Homo sapiens TAF11 RNA polymerase II, TATA box binding protein(TBP)-associated factor, 28kDa (TAF11), mRNA. DQ896569 - Synthetic construct Homo sapiens clone IMAGE:100011029; FLH195512.01L; RZPDo839D04151D TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa (TAF11) gene, encodes complete protein. AB464280 - Synthetic construct DNA, clone: pF1KB7569, Homo sapiens TAF11 gene for TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa, without stop codon, in Flexi system. CR542068 - Homo sapiens full open reading frame cDNA clone RZPDo834G0636D for gene TAF11, TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa; complete cds, without stopcodon. LF340907 - JP 2014500723-A/148410: Polycomb-Associated Non-Coding RNAs. LF340908 - JP 2014500723-A/148411: Polycomb-Associated Non-Coding RNAs. JD139393 - Sequence 120417 from Patent EP1572962. JD255588 - Sequence 236612 from Patent EP1572962. MA446341 - JP 2018138019-A/18267: Polycomb-Associated Non-Coding RNAs. MA576484 - JP 2018138019-A/148410: Polycomb-Associated Non-Coding RNAs. MA576485 - JP 2018138019-A/148411: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q15544 (Reactome details) participates in the following event(s):
R-HSA-109636 Recognition and Binding of Core Promoter Elements by TFIID R-HSA-73946 Abortive initiation R-HSA-75856 Abortive Initiation Before Second Transition R-HSA-75873 Addition of Nucleotides 5 through 9 on the growing Transcript R-HSA-167136 Addition of nucleotides 5 through 9 on the growing HIV-1 transcript R-HSA-167474 Abortive HIV-1 Initiation Before Second Transition R-HSA-167477 Abortive HIV-1 initiation after formation of the first phosphodiester bond R-HSA-6810234 General transcription factors bind SNAPc:POU2F1:ZNF143:snRNA gene R-HSA-75866 Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP R-HSA-75861 NTP Binds Active Site of RNA Polymerase II R-HSA-75864 Newly Formed Phosphodiester Bond Stabilized and PPi Released R-HSA-109637 Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex R-HSA-75862 Fall Back to Closed Pre-initiation Complex R-HSA-75949 RNA Polymerase II Promoter Opening: First Transition R-HSA-167134 Newly formed phosphodiester bond stabilized and PPi released R-HSA-167130 Nucleophillic attack by 3'-hydroxyl oxygen of nascent HIV-1 transcript on the Alpha phosphate of NTP R-HSA-167118 NTP binds active site of RNA Polymerase II in HIV-1 open pre-initiation complex R-HSA-167484 Fall Back to Closed Pre-initiation Complex R-HSA-167097 HIV Promoter Opening: First Transition R-HSA-6805399 TAF1 phosphorylates TP53 R-HSA-6810238 RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) R-HSA-109638 Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex R-HSA-6810235 RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain R-HSA-6810233 CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter R-HSA-6814885 CBCAP complex binds 7-methylguanosine cap of snRNA R-HSA-75095 Binding of TFIIE to the growing preinitiation complex R-HSA-109639 Formation of the closed pre-initiation complex R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-674695 RNA Polymerase II Pre-transcription Events R-HSA-73776 RNA Polymerase II Promoter Escape R-HSA-167162 RNA Polymerase II HIV Promoter Escape R-HSA-167161 HIV Transcription Initiation R-HSA-6807505 RNA polymerase II transcribes snRNA genes R-HSA-75953 RNA Polymerase II Transcription Initiation R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-167172 Transcription of the HIV genome R-HSA-73857 RNA Polymerase II Transcription R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation R-HSA-162599 Late Phase of HIV Life Cycle R-HSA-74160 Gene expression (Transcription) R-HSA-5633007 Regulation of TP53 Activity R-HSA-162587 HIV Life Cycle R-HSA-3700989 Transcriptional Regulation by TP53 R-HSA-162906 HIV Infection R-HSA-212436 Generic Transcription Pathway R-HSA-5663205 Infectious disease R-HSA-1643685 Disease
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
