ID:TAF4_HUMAN DESCRIPTION: RecName: Full=Transcription initiation factor TFIID subunit 4; AltName: Full=RNA polymerase II TBP-associated factor subunit C; AltName: Full=TBP-associated factor 4; AltName: Full=Transcription initiation factor TFIID 130 kDa subunit; Short=TAF(II)130; Short=TAFII-130; Short=TAFII130; AltName: Full=Transcription initiation factor TFIID 135 kDa subunit; Short=TAF(II)135; Short=TAFII-135; Short=TAFII135; FUNCTION: Makes part of TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Potentiates transcriptional activation by the AF-2S of the retinoic acid, vitamin D3 and thyroid hormone. SUBUNIT: TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). Component of the TFTC-HAT complex, at least composed of TAF5L, TAF6L, TADA3L, SUPT3H, TAF2, TAF4, TAF5, GCN5L2/GCN5, TAF10 and TRRAP. Component of some MLL1/MLL complex, at least composed of the core components MLL, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components C17orf49, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with ATF7; the interaction inhibits ATF7- mediated tranactivation. Interacts with SV40 Large T antigen. SUBCELLULAR LOCATION: Nucleus. SIMILARITY: Belongs to the TAF4 family. SIMILARITY: Contains 1 TAFH (NHR1) domain. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/taf4/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O00268
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0003713 transcription coactivator activity GO:0005515 protein binding GO:0017162 aryl hydrocarbon receptor binding GO:0046982 protein heterodimerization activity GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly
Biological Process: GO:0001541 ovarian follicle development GO:0006351 transcription, DNA-templated GO:0006352 DNA-templated transcription, initiation GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0006366 transcription from RNA polymerase II promoter GO:0006367 transcription initiation from RNA polymerase II promoter GO:0016032 viral process GO:0045893 positive regulation of transcription, DNA-templated GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly GO:1901796 regulation of signal transduction by p53 class mediator
U75308 - Human TBP-associated factor (hTAFII130) mRNA, partial cds. AK123937 - Homo sapiens cDNA FLJ41943 fis, clone PERIC2009566, highly similar to TRANSCRIPTION INITIATION FACTOR TFIID 135 KDA SUBUNIT. AK097744 - Homo sapiens cDNA FLJ40425 fis, clone TESTI2039038, weakly similar to TRANSCRIPTION INITIATION FACTOR TFIID 135 KDA SUBUNIT. Y11354 - H.sapiens mRNA for TAFII135. BC167776 - Synthetic construct Homo sapiens clone IMAGE:100068166, MGC:195783 TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa (TAF4) mRNA, encodes complete protein. JD242567 - Sequence 223591 from Patent EP1572962. JD300876 - Sequence 281900 from Patent EP1572962. JD314147 - Sequence 295171 from Patent EP1572962. JD110824 - Sequence 91848 from Patent EP1572962. JD370845 - Sequence 351869 from Patent EP1572962. JD419881 - Sequence 400905 from Patent EP1572962. JD458045 - Sequence 439069 from Patent EP1572962. JD127081 - Sequence 108105 from Patent EP1572962. JD392771 - Sequence 373795 from Patent EP1572962. JD389947 - Sequence 370971 from Patent EP1572962. JD566434 - Sequence 547458 from Patent EP1572962. AK097268 - Homo sapiens cDNA FLJ39949 fis, clone SPLEN2024383, moderately similar to TRANSCRIPTION INITIATION FACTOR TFIID 135 KDA SUBUNIT.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein O00268 (Reactome details) participates in the following event(s):
R-HSA-109636 Recognition and Binding of Core Promoter Elements by TFIID R-HSA-73946 Abortive initiation R-HSA-75856 Abortive Initiation Before Second Transition R-HSA-75873 Addition of Nucleotides 5 through 9 on the growing Transcript R-HSA-167136 Addition of nucleotides 5 through 9 on the growing HIV-1 transcript R-HSA-167474 Abortive HIV-1 Initiation Before Second Transition R-HSA-167477 Abortive HIV-1 initiation after formation of the first phosphodiester bond R-HSA-75866 Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP R-HSA-75861 NTP Binds Active Site of RNA Polymerase II R-HSA-75864 Newly Formed Phosphodiester Bond Stabilized and PPi Released R-HSA-109637 Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex R-HSA-75862 Fall Back to Closed Pre-initiation Complex R-HSA-75949 RNA Polymerase II Promoter Opening: First Transition R-HSA-167134 Newly formed phosphodiester bond stabilized and PPi released R-HSA-167130 Nucleophillic attack by 3'-hydroxyl oxygen of nascent HIV-1 transcript on the Alpha phosphate of NTP R-HSA-167118 NTP binds active site of RNA Polymerase II in HIV-1 open pre-initiation complex R-HSA-167484 Fall Back to Closed Pre-initiation Complex R-HSA-167097 HIV Promoter Opening: First Transition R-HSA-6805399 TAF1 phosphorylates TP53 R-HSA-109638 Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex R-HSA-75095 Binding of TFIIE to the growing preinitiation complex R-HSA-109639 Formation of the closed pre-initiation complex R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-674695 RNA Polymerase II Pre-transcription Events R-HSA-73776 RNA Polymerase II Promoter Escape R-HSA-167162 RNA Polymerase II HIV Promoter Escape R-HSA-167161 HIV Transcription Initiation R-HSA-75953 RNA Polymerase II Transcription Initiation R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-167172 Transcription of the HIV genome R-HSA-73857 RNA Polymerase II Transcription R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation R-HSA-162599 Late Phase of HIV Life Cycle R-HSA-74160 Gene expression (Transcription) R-HSA-5633007 Regulation of TP53 Activity R-HSA-162587 HIV Life Cycle R-HSA-3700989 Transcriptional Regulation by TP53 R-HSA-162906 HIV Infection R-HSA-212436 Generic Transcription Pathway R-HSA-5663205 Infectious disease R-HSA-1643685 Disease
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
