Human Gene TALDO1 (ENST00000319006.8_4) from GENCODE V47lift37
  Description: transaldolase 1 (from RefSeq NM_006755.2)
Gencode Transcript: ENST00000319006.8_4
Gencode Gene: ENSG00000177156.11_7
Transcript (Including UTRs)
   Position: hg19 chr11:747,464-765,012 Size: 17,549 Total Exon Count: 8 Strand: +
Coding Region
   Position: hg19 chr11:747,482-764,845 Size: 17,364 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:747,464-765,012)mRNA (may differ from genome)Protein (337 aa)
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-  Comments and Description Text from UniProtKB
  ID: TALDO_HUMAN
DESCRIPTION: RecName: Full=Transaldolase; EC=2.2.1.2;
FUNCTION: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
CATALYTIC ACTIVITY: Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate.
PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D- glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D- ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.
SUBUNIT: Homodimer.
INTERACTION: O95777:NAA38; NbExp=1; IntAct=EBI-1056712, EBI-347779;
SUBCELLULAR LOCATION: Cytoplasm (Probable).
DISEASE: Defects in TALDO1 are the cause of transaldolase 1 deficiency (TALDO1 deficiency) [MIM:606003]. It results in telangiectases of the skin, hepatosplenomegaly, and enlarged clitoris.
SIMILARITY: Belongs to the transaldolase family. Type 1 subfamily.
WEB RESOURCE: Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/TALDO1";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: TALDO1
Diseases sorted by gene-association score: transaldolase deficiency* (1391), ribose 5-phosphate isomerase deficiency (13), fructose intolerance, hereditary (8), senile cataract (7), serine deficiency (5), multiple sclerosis, disease progression, modifier of (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 293.86 RPKM in Whole Blood
Total median expression: 3446.40 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -5.1018-0.283 Picture PostScript Text
3' UTR -40.60167-0.243 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR013785 - Aldolase_TIM
IPR001585 - Transaldolase
IPR004730 - Transaldolase_1
IPR018225 - Transaldolase_AS

Pfam Domains:
PF00923 - Transaldolase/Fructose-6-phosphate aldolase

SCOP Domains:
51569 - Aldolase

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1F05 - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P37837
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologGenome Browser
Gene DetailsGene Details Gene Details Gene Details
Gene SorterGene Sorter Gene Sorter Gene Sorter
 RGDEnsembl  SGD
     Protein Sequence
     Alignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003824 catalytic activity
GO:0004801 sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0030246 carbohydrate binding
GO:0048029 monosaccharide binding

Biological Process:
GO:0005975 carbohydrate metabolic process
GO:0005999 xylulose biosynthetic process
GO:0006002 fructose 6-phosphate metabolic process
GO:0006098 pentose-phosphate shunt
GO:0009052 pentose-phosphate shunt, non-oxidative branch
GO:0019682 glyceraldehyde-3-phosphate metabolic process
GO:0035722 interleukin-12-mediated signaling pathway

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0043231 intracellular membrane-bounded organelle
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  BC010103 - Homo sapiens transaldolase 1, mRNA (cDNA clone MGC:19718 IMAGE:3536661), complete cds.
BC009680 - Homo sapiens transaldolase 1, mRNA (cDNA clone IMAGE:3898596), containing frame-shift errors.
HM005596 - Homo sapiens clone HTL-S-56 testicular secretory protein Li 56 mRNA, complete cds.
L19437 - Homo sapiens transaldolase mRNA, complete cds.
LP747436 - Sequence 23 from Patent WO2018009939.
AK295537 - Homo sapiens cDNA FLJ57988 complete cds, highly similar to Transaldolase (EC 2.2.1.2).
AK313427 - Homo sapiens cDNA, FLJ93966, Homo sapiens transaldolase 1 (TALDO1), mRNA.
AK130060 - Homo sapiens cDNA FLJ26550 fis, clone LNF01586, highly similar to Transaldolase (EC 2.2.1.2).
CU679621 - Synthetic construct Homo sapiens gateway clone IMAGE:100017042 5' read TALDO1 mRNA.
KJ901776 - Synthetic construct Homo sapiens clone ccsbBroadEn_11170 TALDO1 gene, encodes complete protein.
AB528639 - Synthetic construct DNA, clone: pF1KB6418, Homo sapiens TALDO1 gene for transaldolase 1, without stop codon, in Flexi system.
KJ892249 - Synthetic construct Homo sapiens clone ccsbBroadEn_01643 TALDO1 gene, encodes complete protein.
KR710394 - Synthetic construct Homo sapiens clone CCSBHm_00012137 TALDO1 (TALDO1) mRNA, encodes complete protein.
KR710395 - Synthetic construct Homo sapiens clone CCSBHm_00012138 TALDO1 (TALDO1) mRNA, encodes complete protein.
BC018847 - Homo sapiens transaldolase 1, mRNA (cDNA clone IMAGE:3140635), partial cds.
E08515 - DNA encoding novel protein produced by glioblastoma.
E08514 - DNA encoding novel protein produced by glioblastoma.
JD019228 - Sequence 252 from Patent EP1572962.
JD032610 - Sequence 13634 from Patent EP1572962.
JD549630 - Sequence 530654 from Patent EP1572962.
JD111564 - Sequence 92588 from Patent EP1572962.
JD519623 - Sequence 500647 from Patent EP1572962.
JD134263 - Sequence 115287 from Patent EP1572962.
JD502693 - Sequence 483717 from Patent EP1572962.
MB486576 - JP 2019531699-A/23: METHODS FOR DIAGNOSING AND TREATING CANCER.

-  Biochemical and Signaling Pathways
  BioCyc Knowledge Library
NONOXIPENT-PWY - pentose phosphate pathway (non-oxidative branch)

Reactome (by CSHL, EBI, and GO)

Protein P37837 (Reactome details) participates in the following event(s):

R-HSA-71334 sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate
R-HSA-163764 D-fructose 6-phosphate + D-erythrose 4-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
R-HSA-9020591 Interleukin-12 signaling
R-HSA-71336 Pentose phosphate pathway (hexose monophosphate shunt)
R-HSA-163754 Insulin effects increased synthesis of Xylulose-5-Phosphate
R-HSA-447115 Interleukin-12 family signaling
R-HSA-71387 Metabolism of carbohydrates
R-HSA-163685 Energy Metabolism
R-HSA-449147 Signaling by Interleukins
R-HSA-1430728 Metabolism
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: B2R8M2, ENST00000319006.1, ENST00000319006.2, ENST00000319006.3, ENST00000319006.4, ENST00000319006.5, ENST00000319006.6, ENST00000319006.7, NM_006755, O00751, P37837, Q8WV32, Q8WZ45, TAL, TALDO, TALDO1 , TALDOR, TALDO_HUMAN, uc317qoo.1, uc317qoo.2
UCSC ID: ENST00000319006.8_4
RefSeq Accession: NM_006755.2
Protein: P37837 (aka TALDO_HUMAN or TAL1_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.