ID:TANK_HUMAN DESCRIPTION: RecName: Full=TRAF family member-associated NF-kappa-B activator; AltName: Full=TRAF-interacting protein; Short=I-TRAF; FUNCTION: Acts as a regulator of TRAF function by maintaining them in a latent state. Overexpression inhibits TRAF2-mediated NF- kappa-B activation signaled by CD40, TNFR1 and TNFR2. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. May be involved in I-kappa-B-kinase (IKK) regulation; may function as an adapter for kinases such as TBK1 or IKBKE that can modulate IKK activity. SUBUNIT: Interacts with TBK1 (via TRAF-C domain). Interacts with TRAF1 (via TRAF-C domain). Interacts with TRAF2 (via TRAF-C domain); the interaction is disrupted by the phosphorylation of TANK by IKBKE. Interacts with TRAF3 (via TRAF-C domain); the interaction with TRAF3 is weaker than the interactions with TRAF1 and TRAF3. Interacts with IKBKG; the interaction is enhanced by IKBKE and TBK1. Part of a ternary complex consisting of TANK, IKBKB and IKBKG. INTERACTION: O96018:APBA3; NbExp=2; IntAct=EBI-356349, EBI-6115839; P53350:PLK1; NbExp=3; IntAct=EBI-356349, EBI-476768; Q9UHD2:TBK1; NbExp=3; IntAct=EBI-356349, EBI-356402; Q12933:TRAF2; NbExp=3; IntAct=EBI-356349, EBI-355744; Q13114:TRAF3; NbExp=3; IntAct=EBI-356349, EBI-357631; SUBCELLULAR LOCATION: Cytoplasm. TISSUE SPECIFICITY: Ubiquitous. PTM: Phosphorylated by IKBKE. SIMILARITY: Contains 1 C2H2-type zinc finger.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q92844
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
U63830 - Human TRAF family member-associated NF-kB activator TANK mRNA, complete cds. U59863 - Human TRAF-interacting protein I-TRAF mRNA, complete cds. AK313096 - Homo sapiens cDNA, FLJ93580, highly similar to Homo sapiens TRAF family member-associated NFKB activator (TANK), transcript variant 1, mRNA. BC067779 - Homo sapiens TRAF family member-associated NFKB activator, mRNA (cDNA clone MGC:87157 IMAGE:5296558), complete cds. JD114075 - Sequence 95099 from Patent EP1572962. BC003388 - Homo sapiens TRAF family member-associated NFKB activator, mRNA (cDNA clone IMAGE:3446546), complete cds. CU678452 - Synthetic construct Homo sapiens gateway clone IMAGE:100018509 5' read TANK mRNA. BT009855 - Homo sapiens TRAF family member-associated NFKB activator mRNA, complete cds. KJ892895 - Synthetic construct Homo sapiens clone ccsbBroadEn_02289 TANK gene, encodes complete protein. CU688338 - Synthetic construct Homo sapiens gateway clone IMAGE:100022955 5' read TANK mRNA. AB587422 - Synthetic construct DNA, clone: pF1KB6667, Homo sapiens TANK gene for TRAF family member-associated NFKB activator, without stop codon, in Flexi system. KJ898137 - Synthetic construct Homo sapiens clone ccsbBroadEn_07531 TANK gene, encodes complete protein. JD237777 - Sequence 218801 from Patent EP1572962. JD202637 - Sequence 183661 from Patent EP1572962. JD238603 - Sequence 219627 from Patent EP1572962.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_tnfr2Pathway - TNFR2 Signaling Pathway h_stressPathway - TNF/Stress Related Signaling
Reactome (by CSHL, EBI, and GO)
Protein Q92844 (Reactome details) participates in the following event(s):
R-HSA-933537 Recruitment of TANK to TRAF6 R-HSA-5362486 TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR4 R-HSA-9013985 TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR3 R-HSA-933527 Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6 R-HSA-936941 Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR4 followed by their phosphorylation R-HSA-9013986 Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR3 followed by their phosphorylation R-HSA-933538 Recruitment of IRF7 to TRAF6 R-HSA-933525 Phosphorylation and release of IRF7 R-HSA-166271 IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 R-HSA-166245 Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex R-HSA-9013979 IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR3 R-HSA-9013978 Phosphorylation of IRF-3/IRF7 and their release from the activated TLR3 complex R-HSA-933541 TRAF6 mediated IRF7 activation R-HSA-936964 Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon R-HSA-9013973 TICAM1-dependent activation of IRF3/IRF7 R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-937061 TRIF(TICAM1)-mediated TLR4 signaling R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade R-HSA-168249 Innate Immune System R-HSA-166166 MyD88-independent TLR4 cascade R-HSA-168898 Toll-Like Receptors Cascades R-HSA-168256 Immune System R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
