Human Gene TAP1 (ENST00000354258.5_9) from GENCODE V47lift37
  Description: transporter 1, ATP binding cassette subfamily B member, transcript variant 2 (from RefSeq NM_001292022.2)
Gencode Transcript: ENST00000354258.5_9
Gencode Gene: ENSG00000168394.13_12
Transcript (Including UTRs)
   Position: hg19 chr6:32,812,986-32,821,481 Size: 8,496 Total Exon Count: 11 Strand: -
Coding Region
   Position: hg19 chr6:32,813,356-32,821,413 Size: 8,058 Coding Exon Count: 11 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureOther SpeciesmRNA DescriptionsOther Names
Model InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:32,812,986-32,821,481)mRNA (may differ from genome)Protein (748 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MalacardsMGIOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: TAP1
Diseases sorted by gene-association score: bare lymphocyte syndrome, type i* (654), immunodeficiency by defective expression of hla class 1* (433), herpes simplex (13), orbital melanoma (12), spondylitis (12), hereditary choroidal atrophy (8), cleft soft palate (7), choroidal sclerosis (7), partial central choroid dystrophy (7), branchiootorenal syndrome (5), idiopathic bronchiectasis (5)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 118.93 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 900.97 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -34.9068-0.513 Picture PostScript Text
3' UTR -95.90370-0.259 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Descriptions from all associated GenBank mRNAs
  LF210795 - JP 2014500723-A/18298: Polycomb-Associated Non-Coding RNAs.
AK093980 - Homo sapiens cDNA FLJ36661 fis, clone UTERU2002736.
AX748392 - Sequence 1917 from Patent EP1308459.
BC001587 - Homo sapiens cDNA clone IMAGE:2966578, **** WARNING: chimeric clone ****.
BC001849 - Homo sapiens cDNA clone IMAGE:2966578, **** WARNING: chimeric clone ****.
BC014081 - Homo sapiens transporter 1, ATP-binding cassette, sub-family B (MDR/TAP), mRNA (cDNA clone MGC:20334 IMAGE:4304716), complete cds.
LQ882898 - Sequence 47 from Patent WO2018160841.
BX648013 - Homo sapiens mRNA; cDNA DKFZp686L1859 (from clone DKFZp686L1859).
AK130176 - Homo sapiens cDNA FLJ26666 fis, clone MPG02817, highly similar to ANTIGEN PEPTIDE TRANSPORTER 1.
AK123494 - Homo sapiens cDNA FLJ41500 fis, clone BRTHA2006974, highly similar to ANTIGEN PEPTIDE TRANSPORTER 1.
AK302340 - Homo sapiens cDNA FLJ53627 complete cds, highly similar to Antigen peptide transporter 1.
X57522 - H.sapiens RING4 cDNA.
JD308536 - Sequence 289560 from Patent EP1572962.
LF341243 - JP 2014500723-A/148746: Polycomb-Associated Non-Coding RNAs.
JD160208 - Sequence 141232 from Patent EP1572962.
AH007356 - Homo sapiens Unknown (TAP1) mRNA, TAP1-A allele, complete cds.
AH007357 - Homo sapiens Unknown (TAP1) mRNA, TAP1-C allele, complete cds.
JD257599 - Sequence 238623 from Patent EP1572962.
JD317734 - Sequence 298758 from Patent EP1572962.
JD164761 - Sequence 145785 from Patent EP1572962.
JD537834 - Sequence 518858 from Patent EP1572962.
JD414063 - Sequence 395087 from Patent EP1572962.
AY523970 - Homo sapiens TAP1 (TAP1) mRNA, TAP1*02 variant allele, complete cds.
AY523971 - Homo sapiens TAP1 (TAP1) mRNA, TAP1*020101 allele, complete cds.
KJ892250 - Synthetic construct Homo sapiens clone ccsbBroadEn_01644 TAP1 gene, encodes complete protein.
AB012644 - Homo sapiens TAP1*0102N mRNA for TAP1N, complete cds.
L21204 - Homo sapiens peptide transporter (TAP1) mRNA, complete cds.
L21205 - Homo sapiens peptide transporter (TAP1) mRNA, complete cds.
L21206 - Homo sapiens peptide transporter (TAP1) mRNA, complete cds.
L21207 - Homo sapiens peptide transporter (TAP1) mRNA, complete cds.
L21208 - Homo sapiens peptide transporter (TAP1) mRNA, complete cds.
AK313762 - Homo sapiens cDNA, FLJ94363, highly similar to Homo sapiens transporter 1, ATP-binding cassette, sub-family B(MDR/TAP) (TAP1), mRNA.
DQ896350 - Synthetic construct Homo sapiens clone IMAGE:100010810; FLH193530.01L; RZPDo839H0368D transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) (TAP1) gene, encodes complete protein.
EU176425 - Synthetic construct Homo sapiens clone IMAGE:100006629; FLH264105.01X; RZPDo839E05257D transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) (TAP1) gene, encodes complete protein.
AB528393 - Synthetic construct DNA, clone: pF1KB5751, Homo sapiens TAP1 gene for Antigen peptide transporter 1, without stop codon, in Flexi system.
KU178346 - Homo sapiens transporter 1 ATP-binding cassette sub-family B isoform 1 (TAP1) mRNA, partial cds, alternatively spliced.
KU178347 - Homo sapiens transporter 1 ATP-binding cassette sub-family B isoform 2 (TAP1) mRNA, partial cds, alternatively spliced.
S70266 - TAP1 (TAP1-B) {ATP binding region} [human, Caucasoids, mRNA Partial, 100 nt].
X57521 - H.sapiens partial mRNA Y3 for peptide supply factor gene (PSF).
LF341242 - JP 2014500723-A/148745: Polycomb-Associated Non-Coding RNAs.
LF341241 - JP 2014500723-A/148744: Polycomb-Associated Non-Coding RNAs.
LF212706 - JP 2014500723-A/20209: Polycomb-Associated Non-Coding RNAs.
LQ927262 - Sequence 39 from Patent WO2018191660.
MA446372 - JP 2018138019-A/18298: Polycomb-Associated Non-Coding RNAs.
MA576820 - JP 2018138019-A/148746: Polycomb-Associated Non-Coding RNAs.
MA576819 - JP 2018138019-A/148745: Polycomb-Associated Non-Coding RNAs.
MA576818 - JP 2018138019-A/148744: Polycomb-Associated Non-Coding RNAs.
MA448283 - JP 2018138019-A/20209: Polycomb-Associated Non-Coding RNAs.
MP584548 - Sequence 47 from Patent WO2020081767.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000354258.1, ENST00000354258.2, ENST00000354258.3, ENST00000354258.4, NM_001292022, TAP1 , uc317ynk.1, uc317ynk.2, X5CKB3, X5CKB3_HUMAN
UCSC ID: ENST00000354258.5_9
RefSeq Accession: NM_000593.6

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.