Human Gene TAS2R38 (ENST00000547270.1_6) from GENCODE V47lift37
  Description: taste 2 receptor member 38 (from RefSeq NM_176817.5)
Gencode Transcript: ENST00000547270.1_6
Gencode Gene: ENSG00000257138.1_8
Transcript (Including UTRs)
   Position: hg19 chr7:141,672,431-141,673,573 Size: 1,143 Total Exon Count: 1 Strand: -
Coding Region
   Position: hg19 chr7:141,672,488-141,673,489 Size: 1,002 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:141,672,431-141,673,573)mRNA (may differ from genome)Protein (333 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: Q50KM3_HUMAN
DESCRIPTION: RecName: Full=Taste receptor type 2; Flags: Fragment;
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (By similarity).
SIMILARITY: Belongs to the G-protein coupled receptor T2R family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: TAS2R38
Diseases sorted by gene-association score: alexithymia (9), dental caries (7), common cold (5)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.11 RPKM in Small Intestine - Terminal Ileum
Total median expression: 0.23 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -14.5084-0.173 Picture PostScript Text
3' UTR -6.9057-0.121 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007960 - TAS2_rcpt

Pfam Domains:
PF05296 - Taste receptor protein (TAS2R)

SCOP Domains:
81321 - Family A G protein-coupled receptor-like

ModBase Predicted Comparative 3D Structure on Q50KM3
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0033038 bitter taste receptor activity

Biological Process:
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0050896 response to stimulus
GO:0050909 sensory perception of taste

Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  BC104933 - Homo sapiens taste receptor, type 2, member 38, mRNA (cDNA clone MGC:132593 IMAGE:8143936), complete cds.
BC104937 - Homo sapiens taste receptor, type 2, member 38, mRNA (cDNA clone MGC:132597 IMAGE:8143940), complete cds.
LP896494 - Sequence 1358 from Patent EP3253886.
KJ891936 - Synthetic construct Homo sapiens clone ccsbBroadEn_01330 TAS2R38 gene, encodes complete protein.
KR712166 - Synthetic construct Homo sapiens clone CCSBHm_00036373 TAS2R38 (TAS2R38) mRNA, encodes complete protein.
KR712167 - Synthetic construct Homo sapiens clone CCSBHm_00036374 TAS2R38 (TAS2R38) mRNA, encodes complete protein.
KR712168 - Synthetic construct Homo sapiens clone CCSBHm_00036375 TAS2R38 (TAS2R38) mRNA, encodes complete protein.

-  Other Names for This Gene
  Alternate Gene Symbols: Hosa(Adygei)-T2R38 , NM_176817, Q50KM3, Q50KM3_HUMAN, uc324yeo.1, uc324yeo.2
UCSC ID: ENST00000547270.1_6
RefSeq Accession: NM_176817.5
Protein: Q50KM3

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.