Human Gene TAS2R41 (ENST00000408916.1_4) from GENCODE V47lift37
  Description: taste 2 receptor member 41 (from RefSeq NM_176883.2)
Gencode Transcript: ENST00000408916.1_4
Gencode Gene: ENSG00000221855.1_8
Transcript (Including UTRs)
   Position: hg19 chr7:143,174,966-143,175,889 Size: 924 Total Exon Count: 1 Strand: +
Coding Region
   Position: hg19 chr7:143,174,966-143,175,889 Size: 924 Coding Exon Count: 1 

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RNA-Seq ExpressionMicroarray ExpressionProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:143,174,966-143,175,889)mRNA (may differ from genome)Protein (307 aa)
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-  Comments and Description Text from UniProtKB
  ID: T2R41_HUMAN
DESCRIPTION: RecName: Full=Taste receptor type 2 member 41; Short=T2R41; AltName: Full=Taste receptor type 2 member 59; Short=T2R59;
FUNCTION: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells.
MISCELLANEOUS: Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.
SIMILARITY: Belongs to the G-protein coupled receptor T2R family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
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-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.00 RPKM in (null)
Total median expression: 0.00 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007960 - TAS2_rcpt

Pfam Domains:
PF05296 - Taste receptor protein (TAS2R)

SCOP Domains:
81321 - Family A G protein-coupled receptor-like

ModBase Predicted Comparative 3D Structure on P59536
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0033038 bitter taste receptor activity

Biological Process:
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0050896 response to stimulus
GO:0050909 sensory perception of taste
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste

Cellular Component:
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  BC101157 - Homo sapiens taste receptor, type 2, member 41, mRNA (cDNA clone MGC:119928 IMAGE:40015710), complete cds.
BC101158 - Homo sapiens taste receptor, type 2, member 41, mRNA (cDNA clone MGC:119929 IMAGE:40015713), complete cds.
KJ895932 - Synthetic construct Homo sapiens clone ccsbBroadEn_05326 TAS2R41 gene, encodes complete protein.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P59536 (Reactome details) participates in the following event(s):

R-HSA-3296233 T2Rs bind bitter-tasting compounds
R-HSA-749454 The Ligand:GPCR:Gi complex dissociates
R-HSA-749456 Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi
R-HSA-380073 Liganded Gi-activating GPCR acts as a GEF for Gi
R-HSA-420499 Class C/3 (Metabotropic glutamate/pheromone receptors)
R-HSA-418594 G alpha (i) signalling events
R-HSA-500792 GPCR ligand binding
R-HSA-388396 GPCR downstream signalling
R-HSA-372790 Signaling by GPCR
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: NM_176883, P59536, P59550, Q495I2, Q50KJ5, Q50KJ6, Q50KJ7, Q645W7, T2R41_HUMAN, uc319fcc.1, uc319fcc.2
UCSC ID: ENST00000408916.1_4
RefSeq Accession: NM_176883.2
Protein: P59536 (aka T2R41_HUMAN or TR41_HUMAN)

-  Gene Model Information
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-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.