Human Gene TAS2R42 (ENST00000334266.1_7) from GENCODE V47lift37
  Description: taste 2 receptor member 42 (from RefSeq NM_181429.2)
Gencode Transcript: ENST00000334266.1_7
Gencode Gene: ENSG00000186136.1_9
Transcript (Including UTRs)
   Position: hg19 chr12:11,338,599-11,339,543 Size: 945 Total Exon Count: 3 Strand: -
Coding Region
   Position: hg19 chr12:11,338,599-11,339,543 Size: 945 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:11,338,599-11,339,543)mRNA (may differ from genome)Protein (313 aa)
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BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: T2R42_HUMAN
DESCRIPTION: RecName: Full=Taste receptor type 2 member 42; Short=T2R42; AltName: Full=Taste receptor type 2 member 55; Short=T2R55;
FUNCTION: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
MISCELLANEOUS: Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.
SIMILARITY: Belongs to the G-protein coupled receptor T2R family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
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To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.05 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 0.13 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR017452 - GPCR_Rhodpsn_supfam
IPR007960 - TAS2_rcpt

Pfam Domains:
PF05296 - Taste receptor protein (TAS2R)

SCOP Domains:
81321 - Family A G protein-coupled receptor-like

ModBase Predicted Comparative 3D Structure on Q7RTR8
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0033038 bitter taste receptor activity

Biological Process:
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0050896 response to stimulus
GO:0050909 sensory perception of taste
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste

Cellular Component:
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  KJ896128 - Synthetic construct Homo sapiens clone ccsbBroadEn_05522 TAS2R42 gene, encodes complete protein.
BC131742 - Homo sapiens taste receptor, type 2, member 42, mRNA (cDNA clone MGC:156167 IMAGE:40115195), complete cds.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q7RTR8 (Reactome details) participates in the following event(s):

R-HSA-3296233 T2Rs bind bitter-tasting compounds
R-HSA-749454 The Ligand:GPCR:Gi complex dissociates
R-HSA-749456 Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi
R-HSA-380073 Liganded Gi-activating GPCR acts as a GEF for Gi
R-HSA-420499 Class C/3 (Metabotropic glutamate/pheromone receptors)
R-HSA-418594 G alpha (i) signalling events
R-HSA-500792 GPCR ligand binding
R-HSA-388396 GPCR downstream signalling
R-HSA-372790 Signaling by GPCR
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: A2RRP4, NM_181429, Q645X0, Q7RTR8, T2R42_HUMAN, TAS2R55, uc317txc.1, uc317txc.2
UCSC ID: ENST00000334266.1_7
RefSeq Accession: NM_000014.6
Protein: Q7RTR8 (aka T2R42_HUMAN)

-  Gene Model Information
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-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.