Human Gene TBC1D22B (ENST00000373491.3_4) from GENCODE V47lift37
  Description: TBC1 domain family member 22B, transcript variant 2 (from RefSeq NR_130108.2)
Gencode Transcript: ENST00000373491.3_4
Gencode Gene: ENSG00000065491.8_5
Transcript (Including UTRs)
   Position: hg19 chr6:37,225,548-37,300,746 Size: 75,199 Total Exon Count: 13 Strand: +
Coding Region
   Position: hg19 chr6:37,225,694-37,298,948 Size: 73,255 Coding Exon Count: 13 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:37,225,548-37,300,746)mRNA (may differ from genome)Protein (505 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TB22B_HUMAN
DESCRIPTION: RecName: Full=TBC1 domain family member 22B;
FUNCTION: May act as a GTPase-activating protein for Rab family protein(s) (By similarity).
SIMILARITY: Contains 1 Rab-GAP TBC domain.
SEQUENCE CAUTION: Sequence=BAA91099.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 11.35 RPKM in Skin - Not Sun Exposed (Suprapubic)
Total median expression: 298.32 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -68.60146-0.470 Picture PostScript Text
3' UTR -621.501798-0.346 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000195 - Rab-GTPase-TBC_dom

Pfam Domains:
PF00566 - Rab-GTPase-TBC domain

SCOP Domains:
47923 - Ypt/Rab-GAP domain of gyp1p

Protein Data Bank (PDB) 3-D Structure
MuPIT help
3DZX - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on Q9NU19
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserGenome Browser
Gene DetailsGene Details Gene DetailsGene DetailsGene Details
Gene SorterGene Sorter Gene SorterGene SorterGene Sorter
 RGDEnsembl WormBaseSGD
    Protein SequenceProtein Sequence
    AlignmentAlignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005096 GTPase activator activity
GO:0005515 protein binding
GO:0017137 Rab GTPase binding
GO:0071889 14-3-3 protein binding

Biological Process:
GO:0006886 intracellular protein transport
GO:0031338 regulation of vesicle fusion
GO:0090630 activation of GTPase activity
GO:1902017 regulation of cilium assembly

Cellular Component:
GO:0005622 intracellular
GO:0012505 endomembrane system


-  Descriptions from all associated GenBank mRNAs
  AY313781 - Homo sapiens TBC1 domain-containing protein mRNA, complete cds.
BC047658 - Homo sapiens TBC1 domain family, member 22B, mRNA (cDNA clone IMAGE:5265785).
BC109026 - Homo sapiens TBC1 domain family, member 22B, mRNA (cDNA clone MGC:125626 IMAGE:40027698), complete cds.
BC109027 - Homo sapiens TBC1 domain family, member 22B, mRNA (cDNA clone MGC:125627 IMAGE:40027700), complete cds.
AK096340 - Homo sapiens cDNA FLJ39021 fis, clone NT2RP7003688, moderately similar to Gtpase activating protein for Ypt1p; Gyp1p.
BX648317 - Homo sapiens mRNA; cDNA DKFZp686K07131 (from clone DKFZp686K07131).
AK292893 - Homo sapiens cDNA FLJ77294 complete cds, highly similar to Homo sapiens TBC1 domain family, member 22B (TBC1D22B), mRNA.
KJ899165 - Synthetic construct Homo sapiens clone ccsbBroadEn_08559 TBC1D22B gene, encodes complete protein.
AB449909 - Homo sapiens TBC1D22B mRNA for TBC1 domain family, member 22B, complete cds.
DQ584137 - Homo sapiens piRNA piR-51249, complete sequence.
BC063523 - Homo sapiens TBC1 domain family, member 22B, mRNA (cDNA clone IMAGE:4368802), partial cds.
CR749710 - Homo sapiens mRNA; cDNA DKFZp762J0110 (from clone DKFZp762J0110).
AK000344 - Homo sapiens cDNA FLJ20337 fis, clone HEP12138.
JD093632 - Sequence 74656 from Patent EP1572962.
BC002720 - Homo sapiens TBC1 domain family, member 22B, mRNA (cDNA clone IMAGE:3626417), partial cds.
AY927467 - Homo sapiens mRNA sequence.
AY927466 - Homo sapiens mRNA sequence.
BC000291 - Homo sapiens TBC1 domain family, member 22B, mRNA (cDNA clone IMAGE:2819303), partial cds.
BC000743 - Homo sapiens TBC1 domain family, member 22B, mRNA (cDNA clone IMAGE:2819303), partial cds.
BC001927 - Homo sapiens TBC1 domain family, member 22B, mRNA (cDNA clone IMAGE:2819303), partial cds.
JD548010 - Sequence 529034 from Patent EP1572962.
JD152593 - Sequence 133617 from Patent EP1572962.
JD492367 - Sequence 473391 from Patent EP1572962.
JD355993 - Sequence 337017 from Patent EP1572962.
JD457747 - Sequence 438771 from Patent EP1572962.
JD413030 - Sequence 394054 from Patent EP1572962.
JD223599 - Sequence 204623 from Patent EP1572962.
JD043887 - Sequence 24911 from Patent EP1572962.
JD474260 - Sequence 455284 from Patent EP1572962.
JD292998 - Sequence 274022 from Patent EP1572962.
JD248536 - Sequence 229560 from Patent EP1572962.
JD506913 - Sequence 487937 from Patent EP1572962.
JD199022 - Sequence 180046 from Patent EP1572962.
JD555837 - Sequence 536861 from Patent EP1572962.
JD271712 - Sequence 252736 from Patent EP1572962.
JD436178 - Sequence 417202 from Patent EP1572962.
JD556851 - Sequence 537875 from Patent EP1572962.
JD324946 - Sequence 305970 from Patent EP1572962.
JD484583 - Sequence 465607 from Patent EP1572962.
JD187721 - Sequence 168745 from Patent EP1572962.
JD347957 - Sequence 328981 from Patent EP1572962.
JD066538 - Sequence 47562 from Patent EP1572962.
JD077010 - Sequence 58034 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A8KA28, C6orf197, ENST00000373491.1, ENST00000373491.2, NR_130108, Q32MQ8, Q5VUK9, Q6P4C3, Q7Z6P7, Q9BPV6, Q9BUT5, Q9NU19, Q9NXB6, TB22B_HUMAN, uc318kut.1, uc318kut.2
UCSC ID: ENST00000373491.3_4
RefSeq Accession: NM_017772.4
Protein: Q9NU19 (aka TB22B_HUMAN or CV4L_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.