Human Gene TBCA (ENST00000380377.9_6) from GENCODE V47lift37
  Description: tubulin folding cofactor A, transcript variant 2 (from RefSeq NM_004607.3)
Gencode Transcript: ENST00000380377.9_6
Gencode Gene: ENSG00000171530.15_10
Transcript (Including UTRs)
   Position: hg19 chr5:76,986,991-77,072,163 Size: 85,173 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg19 chr5:76,987,243-77,072,081 Size: 84,839 Coding Exon Count: 4 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:76,986,991-77,072,163)mRNA (may differ from genome)Protein (108 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: TBCA
Diseases sorted by gene-association score: hypoparathyroidism-retardation-dysmorphism syndrome (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 40.53 RPKM in Adrenal Gland
Total median expression: 1136.61 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -22.2082-0.271 Picture PostScript Text
3' UTR -37.80252-0.150 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR004226 - CofA_tubulin-bd

Pfam Domains:
PF02970 - Tubulin binding cofactor A

SCOP Domains:
46988 - Tubulin chaperone cofactor A

ModBase Predicted Comparative 3D Structure on Q6FGD7
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserNo ortholog
Gene DetailsGene Details Gene DetailsGene Details 
Gene SorterGene Sorter Gene SorterGene Sorter 
 RGDEnsembl WormBase 
    Protein Sequence 
    Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0048487 beta-tubulin binding

Biological Process:
GO:0007021 tubulin complex assembly
GO:0007023 post-chaperonin tubulin folding pathway

Cellular Component:
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0015630 microtubule cytoskeleton


-  Descriptions from all associated GenBank mRNAs
  BC105285 - Homo sapiens tubulin folding cofactor A, mRNA (cDNA clone MGC:104402 IMAGE:6702573), complete cds.
AF038952 - Homo sapiens cofactor A protein mRNA, complete cds.
GQ891523 - Homo sapiens clone HEL-S-244 epididymis secretory sperm binding protein mRNA, complete cds.
BC018210 - Homo sapiens tubulin folding cofactor A, mRNA (cDNA clone MGC:9129 IMAGE:3861138), complete cds.
GQ891522 - Homo sapiens clone HEL-S-243 epididymis secretory sperm binding protein mRNA, complete cds.
BC067837 - Homo sapiens tubulin folding cofactor A, mRNA (cDNA clone IMAGE:5286849), with apparent retained intron.
CR542170 - Homo sapiens full open reading frame cDNA clone RZPDo834A0824D for gene TBCA, tubulin-specific chaperone a; complete cds, incl. stopcodon.
AK312207 - Homo sapiens cDNA, FLJ92496, Homo sapiens tubulin-specific chaperone a (TBCA), mRNA.
KJ892252 - Synthetic construct Homo sapiens clone ccsbBroadEn_01646 TBCA gene, encodes complete protein.
BT007354 - Homo sapiens tubulin-specific chaperone a mRNA, complete cds.
CR542186 - Homo sapiens full open reading frame cDNA clone RZPDo834G0424D for gene TBCA, tubulin-specific chaperone a; complete cds, without stopcodon.
AK300031 - Homo sapiens cDNA FLJ57496 complete cds, moderately similar to Tubulin-specific chaperone A.
AK128395 - Homo sapiens cDNA FLJ46538 fis, clone THYMU3037827.
JD378933 - Sequence 359957 from Patent EP1572962.
JD433234 - Sequence 414258 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000380377.1, ENST00000380377.2, ENST00000380377.3, ENST00000380377.4, ENST00000380377.5, ENST00000380377.6, ENST00000380377.7, ENST00000380377.8, hCG_2016016 , NM_004607, Q6FGD7, Q6FGD7_HUMAN, TBCA , uc318poe.1, uc318poe.2
UCSC ID: ENST00000380377.9_6
RefSeq Accession: NM_004607.3
Protein: Q6FGD7

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.