Human Gene TBKBP1 (ENST00000578982.6_9) from GENCODE V47lift37
  Description: TBK1 binding protein 1, transcript variant 1 (from RefSeq NM_001394755.1)
Gencode Transcript: ENST00000578982.6_9
Gencode Gene: ENSG00000198933.11_14
Transcript (Including UTRs)
   Position: hg19 chr17:45,771,527-45,789,418 Size: 17,892 Total Exon Count: 10 Strand: +
Coding Region
   Position: hg19 chr17:45,773,479-45,787,992 Size: 14,514 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:45,771,527-45,789,418)mRNA (may differ from genome)Protein (615 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblExonPrimerGeneCardsHGNC
MalacardsMGIPubMedUniProtKB

-  Comments and Description Text from UniProtKB
  ID: J3KS71_HUMAN
DESCRIPTION: SubName: Full=TANK-binding kinase 1-binding protein 1; Flags: Fragment;
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: TBKBP1
Diseases sorted by gene-association score: vaccinia (6)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 19.50 RPKM in Brain - Cortex
Total median expression: 446.64 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -27.3068-0.401 Picture PostScript Text
3' UTR -636.401426-0.446 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF12845 - TBD domain

ModBase Predicted Comparative 3D Structure on J3KS71
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Descriptions from all associated GenBank mRNAs
  LF209301 - JP 2014500723-A/16804: Polycomb-Associated Non-Coding RNAs.
AB018318 - Homo sapiens KIAA0775 mRNA for KIAA0775 protein.
BC152407 - Homo sapiens TBK1 binding protein 1, mRNA (cDNA clone MGC:176631 IMAGE:8862510), complete cds.
BC167150 - Homo sapiens TBK1 binding protein 1, mRNA (cDNA clone MGC:176643 IMAGE:8862522), complete cds.
BC111418 - Homo sapiens TBK1 binding protein 1, mRNA (cDNA clone IMAGE:40068358), complete cds.
JD234372 - Sequence 215396 from Patent EP1572962.
JD191375 - Sequence 172399 from Patent EP1572962.
AB383985 - Synthetic construct DNA, clone: pF1KSDA0775, Homo sapiens TBKBP1 gene for TBK1 binding protein 1, complete cds, without stop codon, in Flexi system.
LF327547 - JP 2014500723-A/135050: Polycomb-Associated Non-Coding RNAs.
JD322768 - Sequence 303792 from Patent EP1572962.
JD332520 - Sequence 313544 from Patent EP1572962.
JD121598 - Sequence 102622 from Patent EP1572962.
JD487413 - Sequence 468437 from Patent EP1572962.
JD518433 - Sequence 499457 from Patent EP1572962.
JD135605 - Sequence 116629 from Patent EP1572962.
JD235740 - Sequence 216764 from Patent EP1572962.
LF327538 - JP 2014500723-A/135041: Polycomb-Associated Non-Coding RNAs.
JD126995 - Sequence 108019 from Patent EP1572962.
JD149624 - Sequence 130648 from Patent EP1572962.
JD339914 - Sequence 320938 from Patent EP1572962.
JD305602 - Sequence 286626 from Patent EP1572962.
JD198532 - Sequence 179556 from Patent EP1572962.
JD565766 - Sequence 546790 from Patent EP1572962.
JD219571 - Sequence 200595 from Patent EP1572962.
JD235806 - Sequence 216830 from Patent EP1572962.
JD134767 - Sequence 115791 from Patent EP1572962.
JD483715 - Sequence 464739 from Patent EP1572962.
JD472950 - Sequence 453974 from Patent EP1572962.
JD471323 - Sequence 452347 from Patent EP1572962.
JD339624 - Sequence 320648 from Patent EP1572962.
JD060618 - Sequence 41642 from Patent EP1572962.
JD108911 - Sequence 89935 from Patent EP1572962.
JD118887 - Sequence 99911 from Patent EP1572962.
JD398979 - Sequence 380003 from Patent EP1572962.
JD391012 - Sequence 372036 from Patent EP1572962.
JD437665 - Sequence 418689 from Patent EP1572962.
JD157988 - Sequence 139012 from Patent EP1572962.
JD105238 - Sequence 86262 from Patent EP1572962.
JD545119 - Sequence 526143 from Patent EP1572962.
JD440360 - Sequence 421384 from Patent EP1572962.
JD061924 - Sequence 42948 from Patent EP1572962.
JD038097 - Sequence 19121 from Patent EP1572962.
JD189399 - Sequence 170423 from Patent EP1572962.
JD363280 - Sequence 344304 from Patent EP1572962.
JD060141 - Sequence 41165 from Patent EP1572962.
JD193269 - Sequence 174293 from Patent EP1572962.
JD099537 - Sequence 80561 from Patent EP1572962.
JD226399 - Sequence 207423 from Patent EP1572962.
JD496359 - Sequence 477383 from Patent EP1572962.
JD203105 - Sequence 184129 from Patent EP1572962.
JD203106 - Sequence 184130 from Patent EP1572962.
JD305522 - Sequence 286546 from Patent EP1572962.
JD170622 - Sequence 151646 from Patent EP1572962.
JD066132 - Sequence 47156 from Patent EP1572962.
MA563124 - JP 2018138019-A/135050: Polycomb-Associated Non-Coding RNAs.
MA563115 - JP 2018138019-A/135041: Polycomb-Associated Non-Coding RNAs.
MA444878 - JP 2018138019-A/16804: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000578982.1, ENST00000578982.2, ENST00000578982.3, ENST00000578982.4, ENST00000578982.5, J3KS71, J3KS71_HUMAN, NM_001394755, TBKBP1 , uc326hbj.1, uc326hbj.2
UCSC ID: ENST00000578982.6_9
RefSeq Accession: NM_001394755.1
Protein: J3KS71

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.