ID:TCEA1_HUMAN DESCRIPTION: RecName: Full=Transcription elongation factor A protein 1; AltName: Full=Transcription elongation factor S-II protein 1; AltName: Full=Transcription elongation factor TFIIS.o; FUNCTION: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus. SUBUNIT: Interacts with EAF2 (By similarity). Associates with UBR5 and forms a transcription regulatory complex made of CDK9, RNAP II, UBR5 and TFIIS/TCEA1 that can stimulate target gene transcription (e.g. gamma fibrinogen/FGG) by recruiting their promoters. INTERACTION: Q8WVC0:LEO1; NbExp=4; IntAct=EBI-2608271, EBI-932432; Q8N7H5:PAF1; NbExp=4; IntAct=EBI-2608271, EBI-2607770; SUBCELLULAR LOCATION: Nucleus. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. DISEASE: Note=A chromosomal aberration involving TCEA1 may be a cause of salivary gland pleiomorphic adenomas (PA) [181030]. Pleiomorphic adenomas are the most common benign epithelial tumors of the salivary gland. Translocation t(3;8)(p21;q12) with PLAG1. MISCELLANEOUS: S-II binds to RNA-polymerase II in the absence of transcription. SIMILARITY: Belongs to the TFS-II family. SIMILARITY: Contains 1 TFIIS central domain. SIMILARITY: Contains 1 TFIIS N-terminal domain. SIMILARITY: Contains 1 TFIIS-type zinc finger.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P23193
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
X62585 - H.sapiens mRNA for transcription elongation factor TFIIS-I. M81601 - Human transcription elongation factor (SII) mRNA, complete cds. BC072460 - Homo sapiens transcription elongation factor A (SII), 1, mRNA (cDNA clone MGC:87983 IMAGE:6470030), complete cds. GQ900953 - Homo sapiens clone HEL-T-65 epididymis secretory sperm binding protein mRNA, complete cds. X57198 - Human TFIIS mRNA for transcription elongation factor. BX538034 - Homo sapiens mRNA; cDNA DKFZp686L0676 (from clone DKFZp686L0676). AK297729 - Homo sapiens cDNA FLJ51251 complete cds, moderately similar to Transcription elongation factor A protein 1. AK026617 - Homo sapiens cDNA: FLJ22964 fis, clone KAT10367, highly similar to HUMTEFSII Human transcription elongation factor (SII) mRNA. AK297957 - Homo sapiens cDNA FLJ51911 complete cds, highly similar to Transcription elongation factor A protein 1. AK290454 - Homo sapiens cDNA FLJ78509 complete cds, highly similar to Homo sapiens transcription elongation factor A (SII), 1 (TCEA1), transcript variant 1, mRNA. BT019995 - Homo sapiens transcription elongation factor A (SII), 1 mRNA, complete cds. CR542221 - Homo sapiens full open reading frame cDNA clone RZPDo834B0925D for gene TCEA1, transcription elongation factor A (SII), 1; complete cds, without stopcodon. KJ892256 - Synthetic construct Homo sapiens clone ccsbBroadEn_01650 TCEA1 gene, encodes complete protein. JD299047 - Sequence 280071 from Patent EP1572962. JD224348 - Sequence 205372 from Patent EP1572962. JD503181 - Sequence 484205 from Patent EP1572962. JD102336 - Sequence 83360 from Patent EP1572962. JD325623 - Sequence 306647 from Patent EP1572962. JD434705 - Sequence 415729 from Patent EP1572962. JD292250 - Sequence 273274 from Patent EP1572962. JD069022 - Sequence 50046 from Patent EP1572962. JD080553 - Sequence 61577 from Patent EP1572962. JD359636 - Sequence 340660 from Patent EP1572962. JD126844 - Sequence 107868 from Patent EP1572962. JD552569 - Sequence 533593 from Patent EP1572962. JD244944 - Sequence 225968 from Patent EP1572962. JD049027 - Sequence 30051 from Patent EP1572962. JD431579 - Sequence 412603 from Patent EP1572962. JD486106 - Sequence 467130 from Patent EP1572962. JD461654 - Sequence 442678 from Patent EP1572962. JD271292 - Sequence 252316 from Patent EP1572962. JD458514 - Sequence 439538 from Patent EP1572962. JD056228 - Sequence 37252 from Patent EP1572962. JD458513 - Sequence 439537 from Patent EP1572962. JD056229 - Sequence 37253 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P23193 (Reactome details) participates in the following event(s):
R-HSA-112379 Recruitment of elongation factors to form elongation complex R-HSA-167077 Recruitment of elongation factors to form HIV-1 elongation complex R-HSA-167196 Recruitment of elongation factors to form HIV-1 elongation complex R-HSA-6782004 Assembly of the pre-incision complex in TC-NER R-HSA-113429 Elongating transcript encounters a lesion in the template R-HSA-112385 Addition of nucleotides leads to transcript elongation R-HSA-113411 2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing R-HSA-113412 Pol II elongation complex moves on the template as transcript elongates R-HSA-113414 7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest R-HSA-112392 Resumption of elongation after recovery from pausing R-HSA-113413 TFIIS-mediated recovery of elongation from arrest R-HSA-112395 Abortive termination of elongation after arrest R-HSA-112396 Separation of elongating transcript from template R-HSA-167150 Resumption of elongation of HIV-1 transcript after recovery from pausing R-HSA-167076 2-4 nt.backtracking of Pol II complex on the HIV-1 template leading to elongation pausing R-HSA-167282 2-4 nt.backtracking of Pol II complex on the HIV-1 template leading to elongation pausing R-HSA-167284 7-14 nt. Backtracking of Pol II complex on the HIV-1 template leading to elongation arrest R-HSA-167288 TFIIS-mediated recovery of HIV-1 elongation from arrest R-HSA-167292 Resumption of elongation of HIV-1 transcript after recovery from pausing R-HSA-167148 TFIIS-mediated recovery of elongation from arrest R-HSA-167459 Abortive termination of HIV-1 elongation after arrest (Tat-containing elongation complex) R-HSA-167090 7-14 nt. Backtracking of Pol II complex on the HIV-1 template leading to elongation arrest R-HSA-167192 Pol II elongation complex moves on the HIV-1 template as transcript elongates R-HSA-167181 Addition of nucleotides leads to HIV-1 transcript elongation R-HSA-167197 Separation of elongating HIV-1 transcript from template R-HSA-167481 Abortive termination of HIV-1 elongation after arrest R-HSA-6782069 UVSSA:USP7 deubiquitinates ERCC6 R-HSA-6782131 RNA Pol II backtracking in TC-NER R-HSA-6782138 ERCC5 and RPA bind TC-NER site R-HSA-6782211 DNA polymerases delta, epsilon or kappa bind the TC-NER site R-HSA-6782204 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER R-HSA-6782224 3' incision by ERCC5 (XPG) in TC-NER R-HSA-6782227 Ligation of newly synthesized repair patch to incised DNA in TC-NER R-HSA-6782208 Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER R-HSA-6797616 CCNK:CDK12 binds RNA Pol II at DNA repair genes R-HSA-6782141 Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER R-HSA-6797606 CDK12 phosphorylates RNA Pol II CTD at DNA repair genes R-HSA-112382 Formation of RNA Pol II elongation complex R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-6781823 Formation of TC-NER Pre-Incision Complex R-HSA-674695 RNA Polymerase II Pre-transcription Events R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-75955 RNA Polymerase II Transcription Elongation R-HSA-167238 Pausing and recovery of Tat-mediated HIV elongation R-HSA-167290 Pausing and recovery of HIV elongation R-HSA-167287 HIV elongation arrest and recovery R-HSA-167243 Tat-mediated HIV elongation arrest and recovery R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript R-HSA-6782135 Dual incision in TC-NER R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes R-HSA-167172 Transcription of the HIV genome R-HSA-73857 RNA Polymerase II Transcription R-HSA-5696398 Nucleotide Excision Repair R-HSA-167169 HIV Transcription Elongation R-HSA-3700989 Transcriptional Regulation by TP53 R-HSA-162599 Late Phase of HIV Life Cycle R-HSA-74160 Gene expression (Transcription) R-HSA-73894 DNA Repair R-HSA-212436 Generic Transcription Pathway R-HSA-162587 HIV Life Cycle R-HSA-162906 HIV Infection R-HSA-5663205 Infectious disease R-HSA-1643685 Disease
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
