Human Gene TCEAL2 (ENST00000329035.2_1) from GENCODE V47lift37
  Description: May be involved in transcriptional regulation. (from UniProt Q9H3H9)
Gencode Transcript: ENST00000329035.2_1
Gencode Gene: ENSG00000184905.9_8
Transcript (Including UTRs)
   Position: hg19 chrX:101,380,675-101,382,683 Size: 2,009 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chrX:101,381,803-101,382,486 Size: 684 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chrX:101,380,675-101,382,683)mRNA (may differ from genome)Protein (227 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblExonPrimerGeneCardsHGNCMGI
PubMedUniProtKB

-  Comments and Description Text from UniProtKB
  ID: TCAL2_HUMAN
DESCRIPTION: RecName: Full=Transcription elongation factor A protein-like 2; Short=TCEA-like protein 2; AltName: Full=Transcription elongation factor S-II protein-like 2;
FUNCTION: May be involved in transcriptional regulation.
SUBCELLULAR LOCATION: Nucleus (Probable).
SIMILARITY: Belongs to the TFS-II family. TFA subfamily.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 106.12 RPKM in Pituitary
Total median expression: 1458.30 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -83.80199-0.421 Picture PostScript Text
3' UTR -43.40197-0.220 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR021156 - TF_A-like/BEX-like
IPR010370 - TFA

Pfam Domains:
PF04538 - Brain expressed X-linked like family

ModBase Predicted Comparative 3D Structure on Q9H3H9
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0050699 WW domain binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  AK312138 - Homo sapiens cDNA, FLJ92420, highly similar to Homo sapiens my048 protein (my048), mRNA.
AF063606 - UNVERIFIED: Homo sapiens brain my048 protein mRNA, complete cds.
AF325115 - Homo sapiens MY0876G05 protein (MY876) mRNA, complete cds.
JD205506 - Sequence 186530 from Patent EP1572962.
BC104764 - Homo sapiens transcription elongation factor A (SII)-like 2, mRNA (cDNA clone MGC:132424 IMAGE:8143767), complete cds.
BC093932 - Homo sapiens transcription elongation factor A (SII)-like 2, mRNA (cDNA clone MGC:120967 IMAGE:7939777), complete cds.
AB464729 - Synthetic construct DNA, clone: pF1KB9807, Homo sapiens TCEAL2 gene for transcription elongation factor A (SII)-like 2, without stop codon, in Flexi system.
EU446611 - Synthetic construct Homo sapiens clone IMAGE:100070038; IMAGE:100011820; FLH258266.01L transcription elongation factor A (SII)-like 2 (TCEAL2) gene, encodes complete protein.
JD158617 - Sequence 139641 from Patent EP1572962.
JD273779 - Sequence 254803 from Patent EP1572962.
JD244298 - Sequence 225322 from Patent EP1572962.
JD225108 - Sequence 206132 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: AF063606, B2R5C7, ENST00000329035.1, My048, MY0876G0, Q9H3H9, TCAL2_HUMAN, uc317sqj.1
UCSC ID: ENST00000329035.2_1
RefSeq Accession: NM_080390.4
Protein: Q9H3H9 (aka TCAL2_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.