Human Gene TCF15 (ENST00000246080.4_7) from GENCODE V47lift37 |
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 Sequence and Links to Tools and Databases
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Comments and Description Text from UniProtKB
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ID: TCF15_HUMAN
DESCRIPTION: RecName: Full=Transcription factor 15; Short=TCF-15; AltName: Full=Class A basic helix-loop-helix protein 40; Short=bHLHa40; AltName: Full=Paraxis; AltName: Full=Protein bHLH-EC2;
FUNCTION: May function as an early transcriptional regulator, involved in the patterning of the mesoderm and in lineage determination of cell types derived from the mesoderm.
SUBUNIT: Efficient DNA binding requires dimerization with another bHLH protein (By similarity).
SUBCELLULAR LOCATION: Nucleus (By similarity).
SIMILARITY: Contains 1 bHLH (basic helix-loop-helix) domain.
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Primer design for this transcript
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Comparative Toxicogenomics Database (CTD)
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The following chemicals interact with this gene
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 Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
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Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
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The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
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Protein Domain and Structure Information
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InterPro Domains: Graphical view of domain structure
IPR011598 - HLH_dom
Pfam Domains:
PF00010 - Helix-loop-helix DNA-binding domain
SCOP Domains:
47459 - HLH, helix-loop-helix DNA-binding domain
ModBase Predicted Comparative 3D Structure on Q12870
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
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Orthologous Genes in Other Species
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Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
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Gene Ontology (GO) Annotations with Structured Vocabulary
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Molecular Function:
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0046983 protein dimerization activity
Biological Process:
GO:0001756 somitogenesis
GO:0003016 respiratory system process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0007275 multicellular organism development
GO:0007498 mesoderm development
GO:0007517 muscle organ development
GO:0009952 anterior/posterior pattern specification
GO:0010468 regulation of gene expression
GO:0036342 post-anal tail morphogenesis
GO:0042755 eating behavior
GO:0043583 ear development
GO:0043588 skin development
GO:0045198 establishment of epithelial cell apical/basal polarity
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048339 paraxial mesoderm development
GO:0048644 muscle organ morphogenesis
GO:0048705 skeletal system morphogenesis
GO:0050884 neuromuscular process controlling posture
GO:0060231 mesenchymal to epithelial transition
GO:1903053 regulation of extracellular matrix organization
Cellular Component:
GO:0005634 nucleus
GO:0090575 RNA polymerase II transcription factor complex
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Descriptions from all associated GenBank mRNAs
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BC067836 - Homo sapiens transcription factor 15 (basic helix-loop-helix), mRNA (cDNA clone IMAGE:30347726), partial cds.
U08336 - Human basic helix-loop-helix transcription factor mRNA, complete cds.
JD496224 - Sequence 477248 from Patent EP1572962.
JD105438 - Sequence 86462 from Patent EP1572962.
JD052461 - Sequence 33485 from Patent EP1572962.
JD527010 - Sequence 508034 from Patent EP1572962.
JD541725 - Sequence 522749 from Patent EP1572962.
JD123820 - Sequence 104844 from Patent EP1572962.
JD373015 - Sequence 354039 from Patent EP1572962.
JD179457 - Sequence 160481 from Patent EP1572962.
JD055800 - Sequence 36824 from Patent EP1572962.
JD539842 - Sequence 520866 from Patent EP1572962.
BC160039 - Synthetic construct Homo sapiens clone IMAGE:100063975, MGC:193154 transcription factor 15 (basic helix-loop-helix) (TCF15) mRNA, encodes complete protein.
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Other Names for This Gene
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Alternate Gene Symbols: BHLHA40 , BHLHEC2 , ENST00000246080.1, ENST00000246080.2, ENST00000246080.3, NM_004609, Q12870, Q9NQQ1, TCF15 , TCF15_HUMAN, uc317esm.1, uc317esm.2
UCSC ID: ENST00000246080.4_7
RefSeq Accession: NM_004609.4
Protein: Q12870
(aka TCF15_HUMAN or TF15_HUMAN)
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Gene Model Information
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for a detailed description of the fields of the table above.
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Methods, Credits, and Use Restrictions
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Click here
for details on how this gene model was made and data restrictions if any.
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US Server
