ID:TCF7_HUMAN DESCRIPTION: RecName: Full=Transcription factor 7; Short=TCF-7; AltName: Full=T-cell-specific transcription factor 1; Short=T-cell factor 1; Short=TCF-1; FUNCTION: Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T- lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1. SUBUNIT: Binds the armadillo repeat of CTNNB1 and forms a stable complex. Interacts with AES, TLE1, TLE2, TLE3 and TLE4. SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Predominantly expressed in T-cells. Also detected in proliferating intestinal epithelial cells and in the basal epithelial cells of mammary gland epithelium. INDUCTION: By TCF7L2 and CTNNB1. SIMILARITY: Belongs to the TCF/LEF family. SIMILARITY: Contains 1 HMG box DNA-binding domain. SEQUENCE CAUTION: Sequence=CAA87441.1; Type=Erroneous translation; Note=Wrong choice of frame;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P36402
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005515 protein binding GO:0008013 beta-catenin binding GO:0043565 sequence-specific DNA binding GO:0044212 transcription regulatory region DNA binding
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0006955 immune response GO:0016055 Wnt signaling pathway GO:0021915 neural tube development GO:0030538 embryonic genitalia morphogenesis GO:0033153 T cell receptor V(D)J recombination GO:0042127 regulation of cell proliferation GO:0044336 canonical Wnt signaling pathway involved in negative regulation of apoptotic process GO:0046632 alpha-beta T cell differentiation GO:0048557 embryonic digestive tract morphogenesis GO:0048619 embryonic hindgut morphogenesis GO:0060070 canonical Wnt signaling pathway GO:0071353 cellular response to interleukin-4 GO:1904837 beta-catenin-TCF complex assembly
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
