Human Gene TEAD4 (ENST00000359864.8_14) from GENCODE V47lift37

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Description: TEA domain transcription factor 4, transcript variant 1 (from RefSeq NM_003213.4)
Gencode Transcript: ENST00000359864.8_14
Gencode Gene: ENSG00000197905.10_18
Transcript (Including UTRs)
Position: hg19 chr12:3,068,563-3,149,842 Size: 81,280 Total Exon Count: 13 Strand: +
Coding Region
Position: hg19 chr12:3,103,933-3,149,644 Size: 45,712 Coding Exon Count: 11

Page Index	Sequence and Links	Primers	MalaCards	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr12:3,068,563-3,149,842)			mRNA (may differ from genome)		Protein (434 aa)
Gene Sorter	Genome Browser	Other Species FASTA	Gene interactions	Table Schema	AlphaFold
BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards	HGNC
Malacards	MGI	OMIM	PubMed	UniProtKB	Wikipedia
BioGrid CRISPR DB

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: TEAD4 Diseases sorted by gene-association score: narcolepsy (2)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D001564 Benzo(a)pyrene D015056 1-Methyl-3-isobutylxanthine D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide C547126 AZM551248 D002117 Calcitriol D002251 Carbon Tetrachloride D003300 Copper D016572 Cyclosporine D003907 Dexamethasone D008748 Methylcholanthrene D009151 Mustard Gas C558013 NSC 689534 D010622 Phencyclidine D013739 Testosterone D013749 Tetrachlorodibenzodioxin C044887 beta-methylcholine C045651 epigallocatechin gallate C004925 methylmercuric chloride C027373 potassium chromate(VI) C116926 rofecoxib C089730 rosiglitazone D020122 tert-Butylhydroperoxide

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 27.71 RPKM in Muscle - Skeletal Total median expression: 211.23 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-87.50	207	-0.423	Picture	PostScript	Text
3' UTR	-62.10	198	-0.314	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR000818 - TEA/ATTS
IPR016361 - TEF

Pfam Domains:
PF01285 - TEA/ATTS domain
PF17725 - YAP binding domain

SCOP Domains:
46689 - Homeodomain-like

ModBase Predicted Comparative 3D Structure on Q53GI4


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0035329 hippo signaling Cellular Component: GO:0005654 nucleoplasm

Descriptions from all associated GenBank mRNAs


	AY101179 - Homo sapiens related transcription enhancer factor 1B mRNA, complete cds. BC015497 - Homo sapiens TEA domain family member 4, mRNA (cDNA clone MGC:9014 IMAGE:3913870), complete cds. AK222947 - Homo sapiens mRNA for TEA domain family member 4 isoform 1 variant, clone: HRC10521. U63824 - Human transcription factor RTEF-1 (RTEF1) mRNA, complete cds. BX640921 - Homo sapiens mRNA; cDNA DKFZp686G19178 (from clone DKFZp686G19178). EU446502 - Synthetic construct Homo sapiens clone IMAGE:100070237; IMAGE:100011711; FLH258194.01L TEA domain family member 4 (TEAD4) gene, encodes complete protein. X94438 - Homo sapiens mRNA for TEF-3 protein. CU677317 - Synthetic construct Homo sapiens gateway clone IMAGE:100019089 5' read TEAD4 mRNA. KU178354 - Homo sapiens TEA domain family member 4 isoform 1 (TEAD4) mRNA, partial cds. KU178355 - Homo sapiens TEA domain family member 4 isoform 2 (TEAD4) mRNA, complete cds, alternatively spliced. KU178356 - Homo sapiens TEA domain family member 4 isoform 3 (TEAD4) mRNA, partial cds, alternatively spliced. KJ897651 - Synthetic construct Homo sapiens clone ccsbBroadEn_07045 TEAD4 gene, encodes complete protein. AB528987 - Synthetic construct DNA, clone: pF1KE0919, Homo sapiens TEAD4 gene for TEA domain family member 4, without stop codon, in Flexi system. JD058433 - Sequence 39457 from Patent EP1572962. JD215295 - Sequence 196319 from Patent EP1572962. JD419789 - Sequence 400813 from Patent EP1572962. JD081223 - Sequence 62247 from Patent EP1572962. JD417525 - Sequence 398549 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: ENST00000359864.1, ENST00000359864.2, ENST00000359864.3, ENST00000359864.4, ENST00000359864.5, ENST00000359864.6, ENST00000359864.7, NM_003213, Q53GI4, Q53GI4_HUMAN, TEAD4 , uc318bgj.1, uc318bgj.2 UCSC ID: ENST00000359864.8_14 RefSeq Accession: NM_003213.4 Protein: Q53GI4

Gene Model Information


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Methods, Credits, and Use Restrictions


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