Human Gene TEKT5 (ENST00000283025.7_7) from GENCODE V47lift37
  Description: tektin 5 (from RefSeq NM_144674.2)
Gencode Transcript: ENST00000283025.7_7
Gencode Gene: ENSG00000153060.8_11
Transcript (Including UTRs)
   Position: hg19 chr16:10,721,358-10,788,787 Size: 67,430 Total Exon Count: 7 Strand: -
Coding Region
   Position: hg19 chr16:10,721,440-10,788,730 Size: 67,291 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr16:10,721,358-10,788,787)mRNA (may differ from genome)Protein (485 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MGIOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TEKT5_HUMAN
DESCRIPTION: RecName: Full=Tektin-5;
FUNCTION: Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls of ciliary and flagellar microtubules (By similarity).
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme (By similarity). Cytoplasm, cytoskeleton, flagellum axoneme (By similarity).
SIMILARITY: Belongs to the tektin family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 28.99 RPKM in Testis
Total median expression: 33.58 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -18.1057-0.318 Picture PostScript Text
3' UTR -20.5082-0.250 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000435 - Tektin

Pfam Domains:
PF03148 - Tektin family

ModBase Predicted Comparative 3D Structure on Q96M29
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Biological Process:
GO:0030317 flagellated sperm motility
GO:0060271 cilium assembly
GO:0060294 cilium movement involved in cell motility

Cellular Component:
GO:0005634 nucleus
GO:0005929 cilium
GO:0031514 motile cilium
GO:0036126 sperm flagellum
GO:0042995 cell projection


-  Descriptions from all associated GenBank mRNAs
  BC041081 - Homo sapiens tektin 5, mRNA (cDNA clone IMAGE:3830589), with apparent retained intron.
AK057433 - Homo sapiens cDNA FLJ32871 fis, clone TESTI2003914, weakly similar to Tektin A1.
BC130336 - Homo sapiens tektin 5, mRNA (cDNA clone MGC:163208 IMAGE:40146367), complete cds.
BC130338 - Homo sapiens tektin 5, mRNA (cDNA clone MGC:163210 IMAGE:40146369), complete cds.
HQ258441 - Synthetic construct Homo sapiens clone IMAGE:100072870 tektin 5 (TEKT5) gene, encodes complete protein.
KJ895591 - Synthetic construct Homo sapiens clone ccsbBroadEn_04985 TEKT5 gene, encodes complete protein.
JD544155 - Sequence 525179 from Patent EP1572962.
JD100146 - Sequence 81170 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A1L3Z3, ENST00000283025.1, ENST00000283025.2, ENST00000283025.3, ENST00000283025.4, ENST00000283025.5, ENST00000283025.6, NM_144674, Q96M29, TEKT5_HUMAN, uc317kbh.1, uc317kbh.2
UCSC ID: ENST00000283025.7_7
RefSeq Accession: NM_144674.2
Protein: Q96M29 (aka TEKT5_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.