ID:TELO2_HUMAN DESCRIPTION: RecName: Full=Telomere length regulation protein TEL2 homolog; AltName: Full=Protein clk-2 homolog; Short=hCLK2; FUNCTION: Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. May be involved in telomere length regulation. SUBUNIT: Component of the TTT complex composed of TELO2, TTI1 and TTI2. Interacts with ATM, ATR, MTOR, PRKDC, RUVBL2, TTI1, TTI2, SMG1 and TRRAP. INTERACTION: Q13315:ATM; NbExp=4; IntAct=EBI-1043674, EBI-495465; O43156:TTI1; NbExp=7; IntAct=EBI-1043674, EBI-1055680; SUBCELLULAR LOCATION: Cytoplasm. Membrane. Nucleus. Chromosome, telomere (Probable). MISCELLANEOUS: Cells overexpressing TELO2 are hypersensitive to hydroxyurea (HU) and undergo apoptotic death in response to treatment with HU. SIMILARITY: Belongs to the TEL2 family. SEQUENCE CAUTION: Sequence=BAA31658.3; Type=Erroneous initiation; Note=Translation N-terminally shortened;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9Y4R8
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0032006 regulation of TOR signaling GO:0050821 protein stabilization GO:0071902 positive regulation of protein serine/threonine kinase activity GO:1904263 positive regulation of TORC1 signaling GO:1904515 positive regulation of TORC2 signaling
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
