ID:TE2IP_HUMAN DESCRIPTION: RecName: Full=Telomeric repeat-binding factor 2-interacting protein 1; Short=TERF2-interacting telomeric protein 1; Short=TRF2-interacting telomeric protein 1; AltName: Full=Dopamine receptor-interacting protein 5; AltName: Full=Repressor/activator protein 1 homolog; Short=RAP1 homolog; Short=hRap1; FUNCTION: Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'- TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes. SUBUNIT: Associates with the I-kappa-B-kinase (IKK) core complex, composed of CHUK, IKBKB and IKBKG (By similarity). Homodimer. Component of the shelterin complex (telosome) composed of TERF1, TERF2, TINF2, TERF2IP ACD and POT1. Interacts with TERF2; the interaction is direct. Does not interact with TERF1. Interacts with SLX4/BTBD12. INTERACTION: Q8IY92:SLX4; NbExp=4; IntAct=EBI-750109, EBI-2370740; Q15554:TERF2; NbExp=5; IntAct=EBI-750109, EBI-706637; Q9BSI4-3:TINF2; NbExp=3; IntAct=EBI-750109, EBI-717418; SUBCELLULAR LOCATION: Nucleus. Cytoplasm (By similarity). Chromosome. Chromosome, telomere. Note=Associates with chromosomes, both at telomeres and in extratelomeric sites. Also exists as a cytoplasmic form, where it associates with the IKK complex (By similarity). TISSUE SPECIFICITY: Ubiquitous. Highly expressed. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. MISCELLANEOUS: Shares a bidirectional promoter with KARS (PubMed:14659874). SIMILARITY: Belongs to the RAP1 family. SIMILARITY: Contains 1 BRCT domain. SIMILARITY: Contains 1 Myb-like domain. CAUTION: Was reported to participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair in the absence of TERF2 (PubMed:19763083). However, this probably does not corresponds to its primary function and experiments in mouse showed that it is dispensible for such process and is required for repressiion of homology-directed repair (HDR). SEQUENCE CAUTION: Sequence=AAL55783.1; Type=Frameshift; Positions=151; Sequence=BAA91317.1; Type=Erroneous termination; Positions=299; Note=Translated as Glu; Sequence=BAG60996.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9NYB0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000723 telomere maintenance GO:0001933 negative regulation of protein phosphorylation GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0007004 telomere maintenance via telomerase GO:0010569 regulation of double-strand break repair via homologous recombination GO:0010833 telomere maintenance via telomere lengthening GO:0016233 telomere capping GO:0031848 protection from non-homologous end joining at telomere GO:0032204 regulation of telomere maintenance GO:0032205 negative regulation of telomere maintenance GO:0033138 positive regulation of peptidyl-serine phosphorylation GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0048239 negative regulation of DNA recombination at telomere GO:0051092 positive regulation of NF-kappaB transcription factor activity GO:0070198 protein localization to chromosome, telomeric region GO:1901224 positive regulation of NIK/NF-kappaB signaling GO:1901985 positive regulation of protein acetylation
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
