Human Gene TEX10 (ENST00000374902.9_7) from GENCODE V47lift37

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Description: testis expressed 10, transcript variant 1 (from RefSeq NM_017746.4)
Gencode Transcript: ENST00000374902.9_7
Gencode Gene: ENSG00000136891.14_10
Transcript (Including UTRs)
Position: hg19 chr9:103,064,366-103,115,224 Size: 50,859 Total Exon Count: 15 Strand: -
Coding Region
Position: hg19 chr9:103,064,473-103,111,645 Size: 47,173 Coding Exon Count: 14

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr9:103,064,366-103,115,224)			mRNA (may differ from genome)		Protein (929 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	Reactome	UniProtKB
Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: TEX10_HUMAN DESCRIPTION: RecName: Full=Testis-expressed sequence 10 protein; SUBUNIT: Component of some MLL1/MLL complex, at least composed of the core components MLL, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components C17orf49, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. SUBCELLULAR LOCATION: Nucleus membrane; Multi-pass membrane protein. Nucleus, nucleolus. SIMILARITY: Contains 1 HEAT repeat. SEQUENCE CAUTION: Sequence=CAI12537.1; Type=Erroneous gene model prediction; Sequence=CAI39742.1; Type=Erroneous gene model prediction;

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D015122 6-Mercaptopurine D000082 Acetaminophen D016604 Aflatoxin B1 D001564 Benzo(a)pyrene D019327 Copper Sulfate D016572 Cyclosporine D004147 Dioxins D005839 Gentamicins D006861 Hydrogen Peroxide D013749 Tetrachlorodibenzodioxin more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 9.14 RPKM in Testis Total median expression: 205.62 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-85.00	180	-0.472	Picture	PostScript	Text
3' UTR	-19.00	107	-0.178	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR011989 - ARM-like
IPR016024 - ARM-type_fold
IPR021133 - HEAT_type_2
IPR024679 - IPI1-like_dom

Pfam Domains:
PF12333 - Rix1 complex component involved in 60S ribosome maturation

SCOP Domains:
48371 - ARM repeat
48431 - Lipovitellin-phosvitin complex, superhelical domain

ModBase Predicted Comparative 3D Structure on Q9NXF1


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	Genome Browser	No ortholog
Gene Details	Gene Details		Gene Details	Gene Details
Gene Sorter	Gene Sorter		Gene Sorter	Gene Sorter
	RGD	Ensembl		WormBase
				Protein Sequence
				Alignment

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0005515 protein binding Biological Process: GO:0006364 rRNA processing Cellular Component: GO:0005634 nucleus GO:0005654 nucleoplasm GO:0005730 nucleolus GO:0005737 cytoplasm GO:0071339 MLL1 complex GO:0097344 Rix1 complex

Descriptions from all associated GenBank mRNAs


	KJ899032 - Synthetic construct Homo sapiens clone ccsbBroadEn_08426 TEX10 gene, encodes complete protein. AJ420436 - Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 1562444. BC030652 - Homo sapiens testis expressed 10, mRNA (cDNA clone MGC:33005 IMAGE:5268105), complete cds. AB060968 - Homo sapiens nbla10363 mRNA, complete cds. AK091669 - Homo sapiens cDNA FLJ34350 fis, clone FEBRA2011090. AK302619 - Homo sapiens cDNA FLJ57815 complete cds. AK000294 - Homo sapiens cDNA FLJ20287 fis, clone HEP04390. AK298916 - Homo sapiens cDNA FLJ54377 complete cds. JD244850 - Sequence 225874 from Patent EP1572962. AY598337 - Homo sapiens L18 mRNA, complete cds. JF432490 - Synthetic construct Homo sapiens clone IMAGE:100073711 testis expressed 10 (TEX10) gene, encodes complete protein. JD024062 - Sequence 5086 from Patent EP1572962. JD027746 - Sequence 8770 from Patent EP1572962. AK304869 - Homo sapiens cDNA FLJ50387 complete cds. AK303662 - Homo sapiens cDNA FLJ50343 complete cds. JD396872 - Sequence 377896 from Patent EP1572962. JD140459 - Sequence 121483 from Patent EP1572962.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein Q9NXF1 (Reactome details) participates in the following event(s): R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-8868773 rRNA processing in the nucleus and cytosol R-HSA-72312 rRNA processing R-HSA-8953854 Metabolism of RNA

Other Names for This Gene


	Alternate Gene Symbols: B4DYV2, ENST00000374902.1, ENST00000374902.2, ENST00000374902.3, ENST00000374902.4, ENST00000374902.5, ENST00000374902.6, ENST00000374902.7, ENST00000374902.8, L18, Nbla10363, NM_017746, Q5T722, Q5T723, Q8NCN8, Q8TDY0, Q9NXF1, TEX10_HUMAN, uc318lxq.1, uc318lxq.2 UCSC ID: ENST00000374902.9_7 RefSeq Accession: NM_017746.4 Protein: Q9NXF1 (aka TEX10_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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