Human Gene THAP8 (ENST00000292894.2_7) from GENCODE V47lift37
  Description: THAP domain containing 8, transcript variant 1 (from RefSeq NM_152658.3)
Gencode Transcript: ENST00000292894.2_7
Gencode Gene: ENSG00000161277.11_9
Transcript (Including UTRs)
   Position: hg19 chr19:36,525,886-36,545,187 Size: 19,302 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg19 chr19:36,526,342-36,545,119 Size: 18,778 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:36,525,886-36,545,187)mRNA (may differ from genome)Protein (274 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MGIOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: THAP8_HUMAN
DESCRIPTION: RecName: Full=THAP domain-containing protein 8;
SIMILARITY: Contains 1 THAP-type zinc finger.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 11.72 RPKM in Testis
Total median expression: 189.98 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -22.3068-0.328 Picture PostScript Text
3' UTR -145.80456-0.320 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR026522 - THAP8
IPR006612 - Znf_C2CH

Pfam Domains:
PF05485 - THAP domain

SCOP Domains:
57716 - Glucocorticoid receptor-like (DNA-binding domain)

ModBase Predicted Comparative 3D Structure on Q8NA92
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0046872 metal ion binding

Biological Process:
GO:0006357 regulation of transcription from RNA polymerase II promoter


-  Descriptions from all associated GenBank mRNAs
  AK296640 - Homo sapiens cDNA FLJ55220 complete cds, highly similar to THAP domain-containing protein 8.
JD502314 - Sequence 483338 from Patent EP1572962.
AK093048 - Homo sapiens cDNA FLJ35729 fis, clone TESTI2003061.
AX747884 - Sequence 1409 from Patent EP1308459.
JQ410992 - Homo sapiens THAP domain containing 8 transcript variant 2 (THAP8) mRNA, complete cds, alternatively spliced.
BC046207 - Homo sapiens THAP domain containing 8, mRNA (cDNA clone MGC:57845 IMAGE:6176484), complete cds.
BC072416 - Homo sapiens THAP domain containing 8, mRNA (cDNA clone MGC:90181 IMAGE:6169558), complete cds.
AK057453 - Homo sapiens cDNA FLJ32891 fis, clone TESTI2004929.
JD506558 - Sequence 487582 from Patent EP1572962.
AK297630 - Homo sapiens cDNA FLJ52000 complete cds, highly similar to THAP domain-containing protein 8.
JD084771 - Sequence 65795 from Patent EP1572962.
JD108178 - Sequence 89202 from Patent EP1572962.
JD323113 - Sequence 304137 from Patent EP1572962.
JD221446 - Sequence 202470 from Patent EP1572962.
JD383443 - Sequence 364467 from Patent EP1572962.
JD144438 - Sequence 125462 from Patent EP1572962.
HQ447534 - Synthetic construct Homo sapiens clone IMAGE:100070873; CCSB014662_01 THAP domain containing 8 (THAP8) gene, encodes complete protein.
KJ895785 - Synthetic construct Homo sapiens clone ccsbBroadEn_05179 THAP8 gene, encodes complete protein.
KJ900404 - Synthetic construct Homo sapiens clone ccsbBroadEn_09798 THAP8 gene, encodes complete protein.
CU687224 - Synthetic construct Homo sapiens gateway clone IMAGE:100022923 5' read THAP8 mRNA.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000292894.1, NM_152658, Q0P5Z7, Q8NA92, Q96M21, THAP8_HUMAN, uc317lcr.1, uc317lcr.2
UCSC ID: ENST00000292894.2_7
RefSeq Accession: NM_152658.3
Protein: Q8NA92 (aka THAP8_HUMAN or THA8_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.