Human Gene THBS1 (ENST00000260356.6_4) from GENCODE V47lift37
  Description: thrombospondin 1 (from RefSeq NM_003246.4)
Gencode Transcript: ENST00000260356.6_4
Gencode Gene: ENSG00000137801.11_8
Transcript (Including UTRs)
   Position: hg19 chr15:39,873,280-39,891,667 Size: 18,388 Total Exon Count: 22 Strand: +
Coding Region
   Position: hg19 chr15:39,874,059-39,887,570 Size: 13,512 Coding Exon Count: 21 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr15:39,873,280-39,891,667)mRNA (may differ from genome)Protein (1170 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TSP1_HUMAN
DESCRIPTION: RecName: Full=Thrombospondin-1; Flags: Precursor;
FUNCTION: Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating antiangiogenic properties.
SUBUNIT: Homotrimer; disulfide-linked. Interacts (via the TSP type I repeats) with HRG; the interaction blocks the antiangiogenic effect of THBS1 with CD36 (By similarity). Can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta- 1, alpha-V/beta-3 and alpha-IIb/beta-3. Interacts (via the TSP type I repeats) with CD36; the interaction conveys an antiangiogenic effect.
SIMILARITY: Belongs to the thrombospondin family.
SIMILARITY: Contains 2 EGF-like domains.
SIMILARITY: Contains 1 laminin G-like domain.
SIMILARITY: Contains 1 TSP C-terminal (TSPC) domain.
SIMILARITY: Contains 3 TSP type-1 domains.
SIMILARITY: Contains 8 TSP type-3 repeats.
SIMILARITY: Contains 1 VWFC domain.
WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/THBS1ID42548ch15q15.html";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: THBS1
Diseases sorted by gene-association score: thrombotic thrombocytopenic purpura (14), babesiosis (12), posterior uveal melanoma (11), peters-plus syndrome (10), thrombotic thrombocytopenic purpura, acquired (9), intracranial hemorrhage in brain cerebrovascular malformations (9), stiff skin syndrome (8), corneal neovascularization (8), bone giant cell tumor (8), gastric cardia adenocarcinoma (8), diffuse cutaneous systemic sclerosis (6), vascular cancer (4), malaria (4), pancreatic cancer (4), uveal melanoma (3), colorectal cancer (2), hereditary spherocytosis (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 645.79 RPKM in Cells - Cultured fibroblasts
Total median expression: 2310.00 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -59.10179-0.330 Picture PostScript Text
3' UTR -1009.904097-0.246 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR008985 - ConA-like_lec_gl_sf
IPR013320 - ConA-like_subgrp
IPR000742 - EG-like_dom
IPR001881 - EGF-like_Ca-bd
IPR013032 - EGF-like_CS
IPR001791 - Laminin_G
IPR000884 - Thrombospondin_1_rpt
IPR003367 - Thrombospondin_3-like_rpt
IPR017897 - Thrombospondin_3_rpt
IPR008859 - Thrombospondin_C
IPR001007 - VWF_C

Pfam Domains:
PF00090 - Thrombospondin type 1 domain
PF00093 - von Willebrand factor type C domain
PF02412 - Thrombospondin type 3 repeat
PF05735 - Thrombospondin C-terminal region
PF07645 - Calcium-binding EGF domain

SCOP Domains:
49899 - Concanavalin A-like lectins/glucanases
57603 - FnI-like domain
57196 - EGF/Laminin
82895 - TSP-1 type 1 repeat
103647 - TSP type-3 repeat

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1LSL - X-ray MuPIT 1UX6 - X-ray MuPIT 1Z78 - X-ray MuPIT 1ZA4 - X-ray MuPIT 2ERF - X-ray MuPIT 2ES3 - X-ray MuPIT 2OUH - X-ray MuPIT 2OUJ - X-ray MuPIT 3R6B - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P07996
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0001786 phosphatidylserine binding
GO:0001968 fibronectin binding
GO:0005178 integrin binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008201 heparin binding
GO:0017134 fibroblast growth factor binding
GO:0030169 low-density lipoprotein particle binding
GO:0042802 identical protein binding
GO:0043236 laminin binding
GO:0043394 proteoglycan binding
GO:0050431 transforming growth factor beta binding
GO:0050840 extracellular matrix binding
GO:0070051 fibrinogen binding
GO:0070052 collagen V binding

Biological Process:
GO:0000187 activation of MAPK activity
GO:0001666 response to hypoxia
GO:0001937 negative regulation of endothelial cell proliferation
GO:0001953 negative regulation of cell-matrix adhesion
GO:0002040 sprouting angiogenesis
GO:0002544 chronic inflammatory response
GO:0002576 platelet degranulation
GO:0002581 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
GO:0002605 negative regulation of dendritic cell antigen processing and presentation
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0006986 response to unfolded protein
GO:0007050 cell cycle arrest
GO:0007155 cell adhesion
GO:0008284 positive regulation of cell proliferation
GO:0009612 response to mechanical stimulus
GO:0009749 response to glucose
GO:0010595 positive regulation of endothelial cell migration
GO:0010596 negative regulation of endothelial cell migration
GO:0010748 negative regulation of plasma membrane long-chain fatty acid transport
GO:0010751 negative regulation of nitric oxide mediated signal transduction
GO:0010754 negative regulation of cGMP-mediated signaling
GO:0010757 negative regulation of plasminogen activation
GO:0010759 positive regulation of macrophage chemotaxis
GO:0010763 positive regulation of fibroblast migration
GO:0016477 cell migration
GO:0016525 negative regulation of angiogenesis
GO:0018149 peptide cross-linking
GO:0030194 positive regulation of blood coagulation
GO:0030198 extracellular matrix organization
GO:0030335 positive regulation of cell migration
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway
GO:0030823 regulation of cGMP metabolic process
GO:0032026 response to magnesium ion
GO:0032570 response to progesterone
GO:0032695 negative regulation of interleukin-12 production
GO:0032914 positive regulation of transforming growth factor beta1 production
GO:0033574 response to testosterone
GO:0034605 cellular response to heat
GO:0034976 response to endoplasmic reticulum stress
GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway
GO:0042327 positive regulation of phosphorylation
GO:0042493 response to drug
GO:0042535 positive regulation of tumor necrosis factor biosynthetic process
GO:0043032 positive regulation of macrophage activation
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0043537 negative regulation of blood vessel endothelial cell migration
GO:0043652 engulfment of apoptotic cell
GO:0045652 regulation of megakaryocyte differentiation
GO:0045727 positive regulation of translation
GO:0045766 positive regulation of angiogenesis
GO:0048266 behavioral response to pain
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0050921 positive regulation of chemotaxis
GO:0051592 response to calcium ion
GO:0051895 negative regulation of focal adhesion assembly
GO:0051897 positive regulation of protein kinase B signaling
GO:0051918 negative regulation of fibrinolysis
GO:0071356 cellular response to tumor necrosis factor
GO:0071363 cellular response to growth factor stimulus
GO:0071636 positive regulation of transforming growth factor beta production
GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis
GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
GO:1903671 negative regulation of sprouting angiogenesis
GO:2000353 positive regulation of endothelial cell apoptotic process
GO:2000379 positive regulation of reactive oxygen species metabolic process
GO:2001027 negative regulation of endothelial cell chemotaxis
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway

Cellular Component:
GO:0005576 extracellular region
GO:0005577 fibrinogen complex
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016529 sarcoplasmic reticulum
GO:0030141 secretory granule
GO:0031012 extracellular matrix
GO:0031091 platelet alpha granule
GO:0031093 platelet alpha granule lumen
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  LF205837 - JP 2014500723-A/13340: Polycomb-Associated Non-Coding RNAs.
LF211838 - JP 2014500723-A/19341: Polycomb-Associated Non-Coding RNAs.
AK304754 - Homo sapiens cDNA FLJ51203 complete cds, highly similar to Thrombospondin-1 precursor.
AK291639 - Homo sapiens cDNA FLJ76873 complete cds, highly similar to Homo sapiens thrombospondin 1 (THBS1), mRNA.
LP895980 - Sequence 844 from Patent EP3253886.
AB209912 - Homo sapiens mRNA for thrombospondin 1 precursor variant protein.
BC136469 - Homo sapiens thrombospondin 1, mRNA (cDNA clone MGC:168081 IMAGE:9020458), complete cds.
BC136470 - Homo sapiens thrombospondin 1, mRNA (cDNA clone MGC:168082 IMAGE:9020459), complete cds.
M14326 - Human thrombospondin (TSP) mRNA, 5' end.
X14787 - Human mRNA for thrombospondin.
JD129441 - Sequence 110465 from Patent EP1572962.
M25631 - Homo sapiens (clone lambda-TS-33) thrombospondin (THBS) mRNA, 5' end.
X04665 - Human mRNA for thrombospondin.
BC028145 - Homo sapiens thrombospondin 1, mRNA (cDNA clone IMAGE:5217975), partial cds.
JD447946 - Sequence 428970 from Patent EP1572962.
JD364007 - Sequence 345031 from Patent EP1572962.
AB385143 - Synthetic construct DNA, clone: pF1KB5645, Homo sapiens THBS1 gene for thrombospondin-1 precursor, complete cds, without stop codon, in Flexi system.
LF348705 - JP 2014500723-A/156208: Polycomb-Associated Non-Coding RNAs.
LF348707 - JP 2014500723-A/156210: Polycomb-Associated Non-Coding RNAs.
LF348709 - JP 2014500723-A/156212: Polycomb-Associated Non-Coding RNAs.
LF348711 - JP 2014500723-A/156214: Polycomb-Associated Non-Coding RNAs.
LF348712 - JP 2014500723-A/156215: Polycomb-Associated Non-Coding RNAs.
LF348714 - JP 2014500723-A/156217: Polycomb-Associated Non-Coding RNAs.
LF348715 - JP 2014500723-A/156218: Polycomb-Associated Non-Coding RNAs.
LF348718 - JP 2014500723-A/156221: Polycomb-Associated Non-Coding RNAs.
LF348719 - JP 2014500723-A/156222: Polycomb-Associated Non-Coding RNAs.
LF348720 - JP 2014500723-A/156223: Polycomb-Associated Non-Coding RNAs.
LF348722 - JP 2014500723-A/156225: Polycomb-Associated Non-Coding RNAs.
LF348725 - JP 2014500723-A/156228: Polycomb-Associated Non-Coding RNAs.
LN607833 - Homo sapiens partial mRNA for thrombospondin 1 (THBS1 gene).
LF348727 - JP 2014500723-A/156230: Polycomb-Associated Non-Coding RNAs.
LF348728 - JP 2014500723-A/156231: Polycomb-Associated Non-Coding RNAs.
AK310820 - Homo sapiens cDNA, FLJ17862.
LF348729 - JP 2014500723-A/156232: Polycomb-Associated Non-Coding RNAs.
AK293230 - Homo sapiens cDNA FLJ52119 complete cds.
LF348731 - JP 2014500723-A/156234: Polycomb-Associated Non-Coding RNAs.
LF348733 - JP 2014500723-A/156236: Polycomb-Associated Non-Coding RNAs.
LF348735 - JP 2014500723-A/156238: Polycomb-Associated Non-Coding RNAs.
LF348737 - JP 2014500723-A/156240: Polycomb-Associated Non-Coding RNAs.
LF348739 - JP 2014500723-A/156242: Polycomb-Associated Non-Coding RNAs.
AK309613 - Homo sapiens cDNA, FLJ99654.
LF348742 - JP 2014500723-A/156245: Polycomb-Associated Non-Coding RNAs.
LF348744 - JP 2014500723-A/156247: Polycomb-Associated Non-Coding RNAs.
LF348745 - JP 2014500723-A/156248: Polycomb-Associated Non-Coding RNAs.
LF348747 - JP 2014500723-A/156250: Polycomb-Associated Non-Coding RNAs.
LF348748 - JP 2014500723-A/156251: Polycomb-Associated Non-Coding RNAs.
LF348749 - JP 2014500723-A/156252: Polycomb-Associated Non-Coding RNAs.
LF348750 - JP 2014500723-A/156253: Polycomb-Associated Non-Coding RNAs.
LF348751 - JP 2014500723-A/156254: Polycomb-Associated Non-Coding RNAs.
M99425 - Human thrombospondin mRNA, 3' end.
LF348752 - JP 2014500723-A/156255: Polycomb-Associated Non-Coding RNAs.
LF348753 - JP 2014500723-A/156256: Polycomb-Associated Non-Coding RNAs.
LF348754 - JP 2014500723-A/156257: Polycomb-Associated Non-Coding RNAs.
LF348755 - JP 2014500723-A/156258: Polycomb-Associated Non-Coding RNAs.
LF348758 - JP 2014500723-A/156261: Polycomb-Associated Non-Coding RNAs.
JD292490 - Sequence 273514 from Patent EP1572962.
JD341151 - Sequence 322175 from Patent EP1572962.
LF348760 - JP 2014500723-A/156263: Polycomb-Associated Non-Coding RNAs.
JD164271 - Sequence 145295 from Patent EP1572962.
JD328837 - Sequence 309861 from Patent EP1572962.
LF348761 - JP 2014500723-A/156264: Polycomb-Associated Non-Coding RNAs.
JD469245 - Sequence 450269 from Patent EP1572962.
JD325730 - Sequence 306754 from Patent EP1572962.
JD373766 - Sequence 354790 from Patent EP1572962.
JD515101 - Sequence 496125 from Patent EP1572962.
JD420045 - Sequence 401069 from Patent EP1572962.
LF348763 - JP 2014500723-A/156266: Polycomb-Associated Non-Coding RNAs.
JD257283 - Sequence 238307 from Patent EP1572962.
LF348764 - JP 2014500723-A/156267: Polycomb-Associated Non-Coding RNAs.
JD060558 - Sequence 41582 from Patent EP1572962.
JD436697 - Sequence 417721 from Patent EP1572962.
JD436698 - Sequence 417722 from Patent EP1572962.
JD309702 - Sequence 290726 from Patent EP1572962.
JD202968 - Sequence 183992 from Patent EP1572962.
JD134430 - Sequence 115454 from Patent EP1572962.
LF348766 - JP 2014500723-A/156269: Polycomb-Associated Non-Coding RNAs.
JD524905 - Sequence 505929 from Patent EP1572962.
LF348767 - JP 2014500723-A/156270: Polycomb-Associated Non-Coding RNAs.
LF348769 - JP 2014500723-A/156272: Polycomb-Associated Non-Coding RNAs.
LF348770 - JP 2014500723-A/156273: Polycomb-Associated Non-Coding RNAs.
JD410868 - Sequence 391892 from Patent EP1572962.
LF348771 - JP 2014500723-A/156274: Polycomb-Associated Non-Coding RNAs.
JD552956 - Sequence 533980 from Patent EP1572962.
LF348772 - JP 2014500723-A/156275: Polycomb-Associated Non-Coding RNAs.
JD232878 - Sequence 213902 from Patent EP1572962.
LF348773 - JP 2014500723-A/156276: Polycomb-Associated Non-Coding RNAs.
LF348775 - JP 2014500723-A/156278: Polycomb-Associated Non-Coding RNAs.
JD313292 - Sequence 294316 from Patent EP1572962.
LF348777 - JP 2014500723-A/156280: Polycomb-Associated Non-Coding RNAs.
LF348778 - JP 2014500723-A/156281: Polycomb-Associated Non-Coding RNAs.
LF348779 - JP 2014500723-A/156282: Polycomb-Associated Non-Coding RNAs.
BC015134 - Homo sapiens, clone IMAGE:3934391, mRNA.
MA584282 - JP 2018138019-A/156208: Polycomb-Associated Non-Coding RNAs.
MA584284 - JP 2018138019-A/156210: Polycomb-Associated Non-Coding RNAs.
MA584286 - JP 2018138019-A/156212: Polycomb-Associated Non-Coding RNAs.
MA584288 - JP 2018138019-A/156214: Polycomb-Associated Non-Coding RNAs.
MA584289 - JP 2018138019-A/156215: Polycomb-Associated Non-Coding RNAs.
MA584291 - JP 2018138019-A/156217: Polycomb-Associated Non-Coding RNAs.
MA584292 - JP 2018138019-A/156218: Polycomb-Associated Non-Coding RNAs.
MA584295 - JP 2018138019-A/156221: Polycomb-Associated Non-Coding RNAs.
MA584296 - JP 2018138019-A/156222: Polycomb-Associated Non-Coding RNAs.
MA584297 - JP 2018138019-A/156223: Polycomb-Associated Non-Coding RNAs.
MA584299 - JP 2018138019-A/156225: Polycomb-Associated Non-Coding RNAs.
MA584302 - JP 2018138019-A/156228: Polycomb-Associated Non-Coding RNAs.
MA584304 - JP 2018138019-A/156230: Polycomb-Associated Non-Coding RNAs.
MA584305 - JP 2018138019-A/156231: Polycomb-Associated Non-Coding RNAs.
MA584306 - JP 2018138019-A/156232: Polycomb-Associated Non-Coding RNAs.
MA584308 - JP 2018138019-A/156234: Polycomb-Associated Non-Coding RNAs.
MA584310 - JP 2018138019-A/156236: Polycomb-Associated Non-Coding RNAs.
MA584312 - JP 2018138019-A/156238: Polycomb-Associated Non-Coding RNAs.
MA584314 - JP 2018138019-A/156240: Polycomb-Associated Non-Coding RNAs.
MA584316 - JP 2018138019-A/156242: Polycomb-Associated Non-Coding RNAs.
MA584319 - JP 2018138019-A/156245: Polycomb-Associated Non-Coding RNAs.
MA584321 - JP 2018138019-A/156247: Polycomb-Associated Non-Coding RNAs.
MA584322 - JP 2018138019-A/156248: Polycomb-Associated Non-Coding RNAs.
MA584324 - JP 2018138019-A/156250: Polycomb-Associated Non-Coding RNAs.
MA584325 - JP 2018138019-A/156251: Polycomb-Associated Non-Coding RNAs.
MA584326 - JP 2018138019-A/156252: Polycomb-Associated Non-Coding RNAs.
MA584327 - JP 2018138019-A/156253: Polycomb-Associated Non-Coding RNAs.
MA584328 - JP 2018138019-A/156254: Polycomb-Associated Non-Coding RNAs.
MA584329 - JP 2018138019-A/156255: Polycomb-Associated Non-Coding RNAs.
MA584330 - JP 2018138019-A/156256: Polycomb-Associated Non-Coding RNAs.
MA584331 - JP 2018138019-A/156257: Polycomb-Associated Non-Coding RNAs.
MA584332 - JP 2018138019-A/156258: Polycomb-Associated Non-Coding RNAs.
MA584335 - JP 2018138019-A/156261: Polycomb-Associated Non-Coding RNAs.
MA584337 - JP 2018138019-A/156263: Polycomb-Associated Non-Coding RNAs.
MA584338 - JP 2018138019-A/156264: Polycomb-Associated Non-Coding RNAs.
MA584340 - JP 2018138019-A/156266: Polycomb-Associated Non-Coding RNAs.
MA584341 - JP 2018138019-A/156267: Polycomb-Associated Non-Coding RNAs.
MA584343 - JP 2018138019-A/156269: Polycomb-Associated Non-Coding RNAs.
MA584344 - JP 2018138019-A/156270: Polycomb-Associated Non-Coding RNAs.
MA584346 - JP 2018138019-A/156272: Polycomb-Associated Non-Coding RNAs.
MA584347 - JP 2018138019-A/156273: Polycomb-Associated Non-Coding RNAs.
MA584348 - JP 2018138019-A/156274: Polycomb-Associated Non-Coding RNAs.
MA584349 - JP 2018138019-A/156275: Polycomb-Associated Non-Coding RNAs.
MA584350 - JP 2018138019-A/156276: Polycomb-Associated Non-Coding RNAs.
MA584352 - JP 2018138019-A/156278: Polycomb-Associated Non-Coding RNAs.
MA584354 - JP 2018138019-A/156280: Polycomb-Associated Non-Coding RNAs.
MA584355 - JP 2018138019-A/156281: Polycomb-Associated Non-Coding RNAs.
MA584356 - JP 2018138019-A/156282: Polycomb-Associated Non-Coding RNAs.
MA441414 - JP 2018138019-A/13340: Polycomb-Associated Non-Coding RNAs.
MA447415 - JP 2018138019-A/19341: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_tsp1Pathway - TSP-1 Induced Apoptosis in Microvascular Endothelial Cell

Reactome (by CSHL, EBI, and GO)

Protein P07996 (Reactome details) participates in the following event(s):

R-HSA-349603 Interaction of integrin alphaIIb beta 3 with THBS1 (Thrombospondin-1)
R-HSA-2681675 Syndecan-1 binds THBS1
R-NUL-2731112 Syndecan-1 binds THBS1
R-HSA-265429 THBS1 (Thrombospondin-1) binds Integrin alpha3beta1, alpha4beta1
R-HSA-5173005 B3GALTL transfers glucose to O-fucosyl-proteins
R-HSA-5173192 POFUT2 transfers fucose to TSR domain-containing proteins
R-HSA-481007 Exocytosis of platelet alpha granule contents
R-HSA-382054 PDGF binds to extracellular matrix proteins
R-HSA-216083 Integrin cell surface interactions
R-HSA-3000170 Syndecan interactions
R-HSA-1474244 Extracellular matrix organization
R-HSA-3000171 Non-integrin membrane-ECM interactions
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-HSA-5173214 O-glycosylation of TSR domain-containing proteins
R-HSA-5083635 Defective B3GALTL causes Peters-plus syndrome (PpS)
R-HSA-114608 Platelet degranulation
R-HSA-186797 Signaling by PDGF
R-HSA-8878171 Transcriptional regulation by RUNX1
R-HSA-5173105 O-linked glycosylation
R-HSA-3906995 Diseases associated with O-glycosylation of proteins
R-HSA-76005 Response to elevated platelet cytosolic Ca2+
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-212436 Generic Transcription Pathway
R-HSA-597592 Post-translational protein modification
R-HSA-3781865 Diseases of glycosylation
R-HSA-76002 Platelet activation, signaling and aggregation
R-HSA-162582 Signal Transduction
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-392499 Metabolism of proteins
R-HSA-1643685 Disease
R-HSA-109582 Hemostasis
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: A8K6H4, B4E3J7, B9EGH6, ENST00000260356.1, ENST00000260356.2, ENST00000260356.3, ENST00000260356.4, ENST00000260356.5, NM_003246, P07996, Q15667, Q59E99, THBS1 , TSP, TSP1, TSP1_HUMAN, uc317gjv.1, uc317gjv.2
UCSC ID: ENST00000260356.6_4
RefSeq Accession: NM_003246.4
Protein: P07996 (aka TSP1_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.