Human Gene THBS2 (ENST00000617924.6_11) from GENCODE V47lift37
  Description: thrombospondin 2, transcript variant 7 (from RefSeq NR_167745.1)
Gencode Transcript: ENST00000617924.6_11
Gencode Gene: ENSG00000186340.17_19
Transcript (Including UTRs)
   Position: hg19 chr6:169,615,880-169,653,941 Size: 38,062 Total Exon Count: 22 Strand: -
Coding Region
   Position: hg19 chr6:169,617,917-169,650,879 Size: 32,963 Coding Exon Count: 21 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:169,615,880-169,653,941)mRNA (may differ from genome)Protein (1172 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCHuman Cortex Gene ExpressionMalacardsMGIOMIMPubMed
ReactomeUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TSP2_HUMAN
DESCRIPTION: RecName: Full=Thrombospondin-2; Flags: Precursor;
FUNCTION: Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36 mediating antiangiogenic properties.
SUBUNIT: Homotrimer; disulfide-linked. Interacts (via the TSP type I repeats) with CD36; the interaction conveys an antiangiogenic effect. Interacts (via the TSP type I repeats) with HRG; the interaction blocks the antiangiogenic effect of THBS2 with CD36 (By similarity). Can bind to fibrinogen, fibronectin, laminin and type V collagen.
INTERACTION: P54290:Cacna2d1 (xeno); NbExp=2; IntAct=EBI-2466249, EBI-2466294;
TISSUE SPECIFICITY: High expression in invertebral disk tissue.
DISEASE: Genetic variations in THBS2 may be a cause of susceptibility to intervertebral disk disease (IDD) [MIM:603932]; also known as lumbar disk herniation (LDH). IDD is one of the most common musculo-skeletal disorders and the predominant cause of low-back pain and unilateral leg pain.
SIMILARITY: Belongs to the thrombospondin family.
SIMILARITY: Contains 2 EGF-like domains.
SIMILARITY: Contains 1 laminin G-like domain.
SIMILARITY: Contains 1 TSP C-terminal (TSPC) domain.
SIMILARITY: Contains 3 TSP type-1 domains.
SIMILARITY: Contains 8 TSP type-3 repeats.
SIMILARITY: Contains 1 VWFC domain.
WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/THBS2ID42549ch6q27.html";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: THBS2
Diseases sorted by gene-association score: intervertebral disc disease* (284), back pain (28), posterior uveal melanoma (23), spinal stenosis (6), intestinal schistosomiasis (6)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -47.50145-0.328 Picture PostScript Text
3' UTR -510.702037-0.251 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR008985 - ConA-like_lec_gl_sf
IPR013320 - ConA-like_subgrp
IPR000742 - EG-like_dom
IPR001881 - EGF-like_Ca-bd
IPR013032 - EGF-like_CS
IPR024731 - EGF_dom_MSP1-like
IPR001791 - Laminin_G
IPR000884 - Thrombospondin_1_rpt
IPR015455 - Thrombospondin_2
IPR003367 - Thrombospondin_3-like_rpt
IPR017897 - Thrombospondin_3_rpt
IPR008859 - Thrombospondin_C
IPR001007 - VWF_C

Pfam Domains:
PF00008 - EGF-like domain
PF00090 - Thrombospondin type 1 domain
PF00093 - von Willebrand factor type C domain
PF02412 - Thrombospondin type 3 repeat
PF05735 - Thrombospondin C-terminal region
PF07645 - Calcium-binding EGF domain
PF12947 - EGF domain

SCOP Domains:
49899 - Concanavalin A-like lectins/glucanases
57603 - FnI-like domain
57196 - EGF/Laminin
82895 - TSP-1 type 1 repeat
103647 - TSP type-3 repeat

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1YO8 - X-ray MuPIT 2RHP - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P35442
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008201 heparin binding

Biological Process:
GO:0007155 cell adhesion
GO:0016525 negative regulation of angiogenesis
GO:0030198 extracellular matrix organization
GO:0051965 positive regulation of synapse assembly

Cellular Component:
GO:0005576 extracellular region
GO:0005604 basement membrane
GO:0031012 extracellular matrix
GO:0031091 platelet alpha granule


-  Descriptions from all associated GenBank mRNAs
  LF210698 - JP 2014500723-A/18201: Polycomb-Associated Non-Coding RNAs.
BC146676 - Homo sapiens thrombospondin 2, mRNA (cDNA clone MGC:165075 IMAGE:40148868), complete cds.
L12350 - Human thrombospondin 2 (THBS2) mRNA, complete cds.
BX641023 - Homo sapiens mRNA; cDNA DKFZp686G02190 (from clone DKFZp686G02190).
DM110843 - Novel Cancer Marker and Use Thereof.
LF340375 - JP 2014500723-A/147878: Polycomb-Associated Non-Coding RNAs.
JD091197 - Sequence 72221 from Patent EP1572962.
JD267603 - Sequence 248627 from Patent EP1572962.
LF340376 - JP 2014500723-A/147879: Polycomb-Associated Non-Coding RNAs.
BC150175 - Homo sapiens thrombospondin 2, mRNA (cDNA clone MGC:164855 IMAGE:40147958), complete cds.
LF340377 - JP 2014500723-A/147880: Polycomb-Associated Non-Coding RNAs.
LF340378 - JP 2014500723-A/147881: Polycomb-Associated Non-Coding RNAs.
JD166319 - Sequence 147343 from Patent EP1572962.
JD090608 - Sequence 71632 from Patent EP1572962.
LF340379 - JP 2014500723-A/147882: Polycomb-Associated Non-Coding RNAs.
JD047036 - Sequence 28060 from Patent EP1572962.
LF340381 - JP 2014500723-A/147884: Polycomb-Associated Non-Coding RNAs.
LF340382 - JP 2014500723-A/147885: Polycomb-Associated Non-Coding RNAs.
M81339 - Human thrombospondin mRNA.
JD559438 - Sequence 540462 from Patent EP1572962.
JD422753 - Sequence 403777 from Patent EP1572962.
JD453767 - Sequence 434791 from Patent EP1572962.
LF340383 - JP 2014500723-A/147886: Polycomb-Associated Non-Coding RNAs.
JD563606 - Sequence 544630 from Patent EP1572962.
JD091076 - Sequence 72100 from Patent EP1572962.
JD358752 - Sequence 339776 from Patent EP1572962.
LF340384 - JP 2014500723-A/147887: Polycomb-Associated Non-Coding RNAs.
JD530486 - Sequence 511510 from Patent EP1572962.
AK292429 - Homo sapiens cDNA FLJ76944 complete cds, highly similar to Homo sapiens thrombospondin 2 (THBS2), mRNA.
LF340385 - JP 2014500723-A/147888: Polycomb-Associated Non-Coding RNAs.
JD475729 - Sequence 456753 from Patent EP1572962.
JD496772 - Sequence 477796 from Patent EP1572962.
LF340386 - JP 2014500723-A/147889: Polycomb-Associated Non-Coding RNAs.
JD287372 - Sequence 268396 from Patent EP1572962.
JD528611 - Sequence 509635 from Patent EP1572962.
LF340388 - JP 2014500723-A/147891: Polycomb-Associated Non-Coding RNAs.
JD068210 - Sequence 49234 from Patent EP1572962.
JD259143 - Sequence 240167 from Patent EP1572962.
JD130544 - Sequence 111568 from Patent EP1572962.
JD048998 - Sequence 30022 from Patent EP1572962.
AB384955 - Synthetic construct DNA, clone: pF1KB4505, Homo sapiens THBS2 gene for thrombospondin-2 precursor, complete cds, without stop codon, in Flexi system.
KJ897671 - Synthetic construct Homo sapiens clone ccsbBroadEn_07065 THBS2 gene, encodes complete protein.
LF340390 - JP 2014500723-A/147893: Polycomb-Associated Non-Coding RNAs.
LF340392 - JP 2014500723-A/147895: Polycomb-Associated Non-Coding RNAs.
LF340393 - JP 2014500723-A/147896: Polycomb-Associated Non-Coding RNAs.
LF340394 - JP 2014500723-A/147897: Polycomb-Associated Non-Coding RNAs.
LF340396 - JP 2014500723-A/147899: Polycomb-Associated Non-Coding RNAs.
LF340397 - JP 2014500723-A/147900: Polycomb-Associated Non-Coding RNAs.
LF340398 - JP 2014500723-A/147901: Polycomb-Associated Non-Coding RNAs.
LF340400 - JP 2014500723-A/147903: Polycomb-Associated Non-Coding RNAs.
LF340403 - JP 2014500723-A/147906: Polycomb-Associated Non-Coding RNAs.
LF340404 - JP 2014500723-A/147907: Polycomb-Associated Non-Coding RNAs.
LF340406 - JP 2014500723-A/147909: Polycomb-Associated Non-Coding RNAs.
LF340407 - JP 2014500723-A/147910: Polycomb-Associated Non-Coding RNAs.
LF340411 - JP 2014500723-A/147914: Polycomb-Associated Non-Coding RNAs.
LF340413 - JP 2014500723-A/147916: Polycomb-Associated Non-Coding RNAs.
LF340415 - JP 2014500723-A/147918: Polycomb-Associated Non-Coding RNAs.
LF340416 - JP 2014500723-A/147919: Polycomb-Associated Non-Coding RNAs.
LF340417 - JP 2014500723-A/147920: Polycomb-Associated Non-Coding RNAs.
LF340418 - JP 2014500723-A/147921: Polycomb-Associated Non-Coding RNAs.
LF340420 - JP 2014500723-A/147923: Polycomb-Associated Non-Coding RNAs.
LF340422 - JP 2014500723-A/147925: Polycomb-Associated Non-Coding RNAs.
LF340423 - JP 2014500723-A/147926: Polycomb-Associated Non-Coding RNAs.
LF340424 - JP 2014500723-A/147927: Polycomb-Associated Non-Coding RNAs.
LF340426 - JP 2014500723-A/147929: Polycomb-Associated Non-Coding RNAs.
LF340427 - JP 2014500723-A/147930: Polycomb-Associated Non-Coding RNAs.
BC127845 - Homo sapiens cDNA clone IMAGE:40131424.
LF340428 - JP 2014500723-A/147931: Polycomb-Associated Non-Coding RNAs.
LF340429 - JP 2014500723-A/147932: Polycomb-Associated Non-Coding RNAs.
LF340431 - JP 2014500723-A/147934: Polycomb-Associated Non-Coding RNAs.
LF340432 - JP 2014500723-A/147935: Polycomb-Associated Non-Coding RNAs.
LF340433 - JP 2014500723-A/147936: Polycomb-Associated Non-Coding RNAs.
LF340434 - JP 2014500723-A/147937: Polycomb-Associated Non-Coding RNAs.
JD337818 - Sequence 318842 from Patent EP1572962.
JD319833 - Sequence 300857 from Patent EP1572962.
LF340435 - JP 2014500723-A/147938: Polycomb-Associated Non-Coding RNAs.
JD565507 - Sequence 546531 from Patent EP1572962.
JD226871 - Sequence 207895 from Patent EP1572962.
LF340437 - JP 2014500723-A/147940: Polycomb-Associated Non-Coding RNAs.
JD099208 - Sequence 80232 from Patent EP1572962.
MA446275 - JP 2018138019-A/18201: Polycomb-Associated Non-Coding RNAs.
MA575952 - JP 2018138019-A/147878: Polycomb-Associated Non-Coding RNAs.
MA575953 - JP 2018138019-A/147879: Polycomb-Associated Non-Coding RNAs.
MA575954 - JP 2018138019-A/147880: Polycomb-Associated Non-Coding RNAs.
MA575955 - JP 2018138019-A/147881: Polycomb-Associated Non-Coding RNAs.
MA575956 - JP 2018138019-A/147882: Polycomb-Associated Non-Coding RNAs.
MA575958 - JP 2018138019-A/147884: Polycomb-Associated Non-Coding RNAs.
MA575959 - JP 2018138019-A/147885: Polycomb-Associated Non-Coding RNAs.
MA575960 - JP 2018138019-A/147886: Polycomb-Associated Non-Coding RNAs.
MA575961 - JP 2018138019-A/147887: Polycomb-Associated Non-Coding RNAs.
MA575962 - JP 2018138019-A/147888: Polycomb-Associated Non-Coding RNAs.
MA575963 - JP 2018138019-A/147889: Polycomb-Associated Non-Coding RNAs.
MA575965 - JP 2018138019-A/147891: Polycomb-Associated Non-Coding RNAs.
MA575967 - JP 2018138019-A/147893: Polycomb-Associated Non-Coding RNAs.
MA575969 - JP 2018138019-A/147895: Polycomb-Associated Non-Coding RNAs.
MA575970 - JP 2018138019-A/147896: Polycomb-Associated Non-Coding RNAs.
MA575971 - JP 2018138019-A/147897: Polycomb-Associated Non-Coding RNAs.
MA575973 - JP 2018138019-A/147899: Polycomb-Associated Non-Coding RNAs.
MA575974 - JP 2018138019-A/147900: Polycomb-Associated Non-Coding RNAs.
MA575975 - JP 2018138019-A/147901: Polycomb-Associated Non-Coding RNAs.
MA575977 - JP 2018138019-A/147903: Polycomb-Associated Non-Coding RNAs.
MA575980 - JP 2018138019-A/147906: Polycomb-Associated Non-Coding RNAs.
MA575981 - JP 2018138019-A/147907: Polycomb-Associated Non-Coding RNAs.
MA575983 - JP 2018138019-A/147909: Polycomb-Associated Non-Coding RNAs.
MA575984 - JP 2018138019-A/147910: Polycomb-Associated Non-Coding RNAs.
MA575988 - JP 2018138019-A/147914: Polycomb-Associated Non-Coding RNAs.
MA575990 - JP 2018138019-A/147916: Polycomb-Associated Non-Coding RNAs.
MA575992 - JP 2018138019-A/147918: Polycomb-Associated Non-Coding RNAs.
MA575993 - JP 2018138019-A/147919: Polycomb-Associated Non-Coding RNAs.
MA575994 - JP 2018138019-A/147920: Polycomb-Associated Non-Coding RNAs.
MA575995 - JP 2018138019-A/147921: Polycomb-Associated Non-Coding RNAs.
MA575997 - JP 2018138019-A/147923: Polycomb-Associated Non-Coding RNAs.
MA575999 - JP 2018138019-A/147925: Polycomb-Associated Non-Coding RNAs.
MA576000 - JP 2018138019-A/147926: Polycomb-Associated Non-Coding RNAs.
MA576001 - JP 2018138019-A/147927: Polycomb-Associated Non-Coding RNAs.
MA576003 - JP 2018138019-A/147929: Polycomb-Associated Non-Coding RNAs.
MA576004 - JP 2018138019-A/147930: Polycomb-Associated Non-Coding RNAs.
MA576005 - JP 2018138019-A/147931: Polycomb-Associated Non-Coding RNAs.
MA576006 - JP 2018138019-A/147932: Polycomb-Associated Non-Coding RNAs.
MA576008 - JP 2018138019-A/147934: Polycomb-Associated Non-Coding RNAs.
MA576009 - JP 2018138019-A/147935: Polycomb-Associated Non-Coding RNAs.
MA576010 - JP 2018138019-A/147936: Polycomb-Associated Non-Coding RNAs.
MA576011 - JP 2018138019-A/147937: Polycomb-Associated Non-Coding RNAs.
MA576012 - JP 2018138019-A/147938: Polycomb-Associated Non-Coding RNAs.
MA576014 - JP 2018138019-A/147940: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P35442 (Reactome details) participates in the following event(s):

R-HSA-5173005 B3GALTL transfers glucose to O-fucosyl-proteins
R-HSA-5173192 POFUT2 transfers fucose to TSR domain-containing proteins
R-HSA-382054 PDGF binds to extracellular matrix proteins
R-HSA-5173214 O-glycosylation of TSR domain-containing proteins
R-HSA-5083635 Defective B3GALTL causes Peters-plus syndrome (PpS)
R-HSA-186797 Signaling by PDGF
R-HSA-5173105 O-linked glycosylation
R-HSA-3906995 Diseases associated with O-glycosylation of proteins
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-597592 Post-translational protein modification
R-HSA-3781865 Diseases of glycosylation
R-HSA-162582 Signal Transduction
R-HSA-392499 Metabolism of proteins
R-HSA-1643685 Disease

-  Other Names for This Gene
  Alternate Gene Symbols: A6H8N1, A7E232, ENST00000617924.1, ENST00000617924.2, ENST00000617924.3, ENST00000617924.4, ENST00000617924.5, NR_167745, P35442, Q5RI52, TSP2, TSP2_HUMAN, uc327rju.1, uc327rju.2
UCSC ID: ENST00000617924.6_11
RefSeq Accession: NM_003247.5
Protein: P35442 (aka TSP2_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.