Human Gene THSD7A (ENST00000423059.9_12) from GENCODE V47lift37
  Description: thrombospondin type 1 domain containing 7A (from RefSeq NM_015204.3)
Gencode Transcript: ENST00000423059.9_12
Gencode Gene: ENSG00000005108.17_14
Transcript (Including UTRs)
   Position: hg19 chr7:11,409,992-11,871,824 Size: 461,833 Total Exon Count: 28 Strand: -
Coding Region
   Position: hg19 chr7:11,415,421-11,871,572 Size: 456,152 Coding Exon Count: 28 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:11,409,992-11,871,824)mRNA (may differ from genome)Protein (1657 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: THS7A_HUMAN
DESCRIPTION: RecName: Full=Thrombospondin type-1 domain-containing protein 7A; Flags: Precursor;
FUNCTION: The soluble form promotes endothelial cell migration and filopodia formationduring angiogenesis via a FAK-dependent mechanism.
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Secreted.
PTM: Proteolytic cleavage in the extracellular region generates a 210 kDa soluble form.
PTM: Extensively N-glycosylated.
SIMILARITY: Contains 15 TSP type-1 domains.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: THSD7A
Diseases sorted by gene-association score: membranous nephropathy (7), osteoporosis (3)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 4.68 RPKM in Nerve - Tibial
Total median expression: 48.65 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -96.30252-0.382 Picture PostScript Text
3' UTR -1248.175429-0.230 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000884 - Thrombospondin_1_rpt

Pfam Domains:
PF00090 - Thrombospondin type 1 domain
PF19028 - Spondin-like TSP1 domain
PF19030 - Thrombospondin type 1 domain
PF19035 - CCN3 Nov like TSP1 domain

SCOP Domains:
82895 - TSP-1 type 1 repeat

ModBase Predicted Comparative 3D Structure on Q9UPZ6
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0001525 angiogenesis
GO:0030154 cell differentiation

Cellular Component:
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AB023177 - Homo sapiens mRNA for KIAA0960 protein, partial cds.
AK092252 - Homo sapiens cDNA FLJ34933 fis, clone NT2RP7005669.
AX747433 - Sequence 958 from Patent EP1308459.
BC030083 - Homo sapiens cDNA clone IMAGE:4791783.
AK001884 - Homo sapiens cDNA FLJ11022 fis, clone PLACE1003771.
JD356877 - Sequence 337901 from Patent EP1572962.
JD565296 - Sequence 546320 from Patent EP1572962.
JD465789 - Sequence 446813 from Patent EP1572962.
JD042029 - Sequence 23053 from Patent EP1572962.
JD521576 - Sequence 502600 from Patent EP1572962.
JD265819 - Sequence 246843 from Patent EP1572962.
JD045993 - Sequence 27017 from Patent EP1572962.
JD549525 - Sequence 530549 from Patent EP1572962.
JD042385 - Sequence 23409 from Patent EP1572962.
JD503050 - Sequence 484074 from Patent EP1572962.
JD491247 - Sequence 472271 from Patent EP1572962.
JD241698 - Sequence 222722 from Patent EP1572962.
JD360155 - Sequence 341179 from Patent EP1572962.
JD504908 - Sequence 485932 from Patent EP1572962.
JD109723 - Sequence 90747 from Patent EP1572962.
JD170883 - Sequence 151907 from Patent EP1572962.
JD050242 - Sequence 31266 from Patent EP1572962.
JD280231 - Sequence 261255 from Patent EP1572962.
JD160273 - Sequence 141297 from Patent EP1572962.
JD332615 - Sequence 313639 from Patent EP1572962.
JD309001 - Sequence 290025 from Patent EP1572962.
JD193525 - Sequence 174549 from Patent EP1572962.
JD538764 - Sequence 519788 from Patent EP1572962.
JD559158 - Sequence 540182 from Patent EP1572962.
JD519637 - Sequence 500661 from Patent EP1572962.
JD549391 - Sequence 530415 from Patent EP1572962.
JD333839 - Sequence 314863 from Patent EP1572962.
JD367403 - Sequence 348427 from Patent EP1572962.
JD341284 - Sequence 322308 from Patent EP1572962.
JD239248 - Sequence 220272 from Patent EP1572962.
JD157918 - Sequence 138942 from Patent EP1572962.
JD256926 - Sequence 237950 from Patent EP1572962.
JD549474 - Sequence 530498 from Patent EP1572962.
JD561790 - Sequence 542814 from Patent EP1572962.
JD095159 - Sequence 76183 from Patent EP1572962.
JD120741 - Sequence 101765 from Patent EP1572962.
JD039985 - Sequence 21009 from Patent EP1572962.
JD442626 - Sequence 423650 from Patent EP1572962.
JD267816 - Sequence 248840 from Patent EP1572962.
JD077549 - Sequence 58573 from Patent EP1572962.
JD158011 - Sequence 139035 from Patent EP1572962.
JD204175 - Sequence 185199 from Patent EP1572962.
JD044328 - Sequence 25352 from Patent EP1572962.
JD526593 - Sequence 507617 from Patent EP1572962.
JD243969 - Sequence 224993 from Patent EP1572962.
JD188922 - Sequence 169946 from Patent EP1572962.
JD350188 - Sequence 331212 from Patent EP1572962.
JD459813 - Sequence 440837 from Patent EP1572962.
JD102980 - Sequence 84004 from Patent EP1572962.
JD199724 - Sequence 180748 from Patent EP1572962.
JD363051 - Sequence 344075 from Patent EP1572962.
JD153434 - Sequence 134458 from Patent EP1572962.
JD178793 - Sequence 159817 from Patent EP1572962.
JD102870 - Sequence 83894 from Patent EP1572962.
JD375602 - Sequence 356626 from Patent EP1572962.
JD051675 - Sequence 32699 from Patent EP1572962.
JD170758 - Sequence 151782 from Patent EP1572962.
JD182292 - Sequence 163316 from Patent EP1572962.
BC016980 - Homo sapiens cDNA clone IMAGE:4183567.
JD555123 - Sequence 536147 from Patent EP1572962.
JD253407 - Sequence 234431 from Patent EP1572962.
JD290811 - Sequence 271835 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9UPZ6 (Reactome details) participates in the following event(s):

R-HSA-5173192 POFUT2 transfers fucose to TSR domain-containing proteins
R-HSA-5173005 B3GALTL transfers glucose to O-fucosyl-proteins
R-HSA-5173214 O-glycosylation of TSR domain-containing proteins
R-HSA-5083635 Defective B3GALTL causes Peters-plus syndrome (PpS)
R-HSA-5173105 O-linked glycosylation
R-HSA-3906995 Diseases associated with O-glycosylation of proteins
R-HSA-597592 Post-translational protein modification
R-HSA-3781865 Diseases of glycosylation
R-HSA-392499 Metabolism of proteins
R-HSA-1643685 Disease

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000423059.1, ENST00000423059.2, ENST00000423059.3, ENST00000423059.4, ENST00000423059.5, ENST00000423059.6, ENST00000423059.7, ENST00000423059.8, KIAA0960, NM_015204, Q9UPZ6, THS7A_HUMAN, uc319sji.1, uc319sji.2
UCSC ID: ENST00000423059.9_12
RefSeq Accession: NM_015204.3
Protein: Q9UPZ6 (aka THS7A_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.